Perspective as a Threshold Concept in Business Communication

In this article, the authors present the notion of perspective as a threshold concept in business communication. Using an SoTL framework, the researchers explore the effect of teaching threshold concepts in a summary writing assignment in a foundational business communication class. Working with a close reading methodology, the authors examine the context of perspective as a threshold concept by analyzing students’ summary samples for gender bias and explore how close reading can support further research into threshold concepts in business communication

Surface and bottom temperature and salinity climatology along the continental shelf off the Canadian and U.S. East Coasts

© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Continental Shelf Research 124 (2016): 165-181, doi:10.1016/j.csr.2016.06.005.A new hydrographic climatology has been created for the continental shelf region, extending from the Labrador shelf to the Mid-Atlantic Bight. The 0.2-degree climatology combines all available observations of surface and bottom temperature and salinity collected between 1950 and 2010 along with the location, depth and date of these measurements. While climatological studies of surface and bottom temperature and salinity have been presented previously for various regions along the Canadian and U.S. shelves, studies also suggest that all these regions are part of one coherent system. This study focuses on the coherent structure of the mean seasonal cycle of surface and bottom temperature and salinity and its variation along the shelf and upper slope. The seasonal cycle of surface temperature is mainly driven by the surface heat flux and exhibits strong dependency on latitude (r≈−0.9). The amplitude of the seasonal cycle of bottom temperature is rather dependent on the depth, while the spatial distribution of bottom temperature is correlated with latitude. The seasonal cycle of surface salinity is influenced by several components, such as sea-ice on the northern shelves and river discharge in the Gulf of St. Lawrence. The bottom salinity exhibits no clear seasonal cycle, but its spatial distribution is highly correlated with bathymetry, thus Slope Water and its intrusion on the shelf can be identified by its relatively high salinity compared to shallow, fresher shelf water. Two different regimes can be identified, especially on the shelf, separated by the Laurentian Channel: advection influences the phasing of the seasonal cycle of surface salinity and bottom temperature to the north, while in the southern region, river runoff and air-sea heat flux forcing are dominant, especially over the shallower bathymetry.Support from NSF OCE PO to Y-OK (OCE-1242989 and OCE-1435602) and SJL (OCE-1332666)

Autism in the Workplace: An Investigation of Germany and the United States

Color poster with text, charts, and graphsThe research team examined the perceptions on whether initiatives in training and hiring individuals with autism can be a competitive advantage. The investigators conducted in-person interviews and explored the initiatives and the perceptions of employees and employers of a variety of companies in both the US and Germany to gain an understanding the potential of individuals with Autism Spectrum Disorder (ASD) as successful members in the workforce and an understanding of the German model of preparing individuals with ASD. The team traveled to Germany because it is the leader in vocational programs for people with ASD.University of Wisconsin--Eau Claire International Fellows Program; University of Wisconsin--Eau Claire Office of Research and Sponsored Program

Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial

. Background: A recombinant factor VIIa analog (NN1731; vatreptacog alfa [activated]) was developed to provide safe, rapid and sustained resolution of bleeds in patients with hemophilia and inhibitors. Patients/Methods: This global, prospective, randomized, double-blinded, active-controlled, dose-escalation trial evaluated and compared one to three doses of vatreptacog alfa at 5, 10, 20, 40, and 80 mu g kg-1 with one to three doses of recombinant FVIIa (rFVIIa) at 90 mu g kg-1 in the treatment of acute joint bleeds in hemophilia patients with inhibitors. The primary endpoint comprised adverse events; secondary endpoints were evaluations of immunogenicity, pharmacokinetics, and efficacy. Results and Conclusions: Overall, 96 joint bleeds in 51 patients (> 12 years of age) were dosed. Vatreptacog alfa was well tolerated, with a low frequency of adverse events. No immunogenic or thrombotic events related to vatreptacog alfa were reported. A high efficacy rate of vatreptacog alfa in controlling acute joint bleeds was observed; 98% of bleeds were controlled within 9 h of the initial dose in a combined evaluation of 2080 mu g kg-1 vatreptacog alfa. The efficacy rate observed for rFVIIa (90%) is consistent with data from published clinical trials. The trial was not powered to compare efficacy, and further trials are needed to investigate the efficacy of vatreptacog alfa as compared with that of rFVIIa. The trial was registered at ClinicalTrials.gov (Registration Number: NCT00486278).1018189Novo NordiskPfizerBaxterBaye

Clinical and laboratory results from adeptTM 1, a phase 2 trial investigating the use of recombinant activated FVII analogue in congenital haemophilia patients with inhibitors

WOS: 00020899280142

One thousand plant transcriptomes and the phylogenomics of green plants

Abstract: Green plants (Viridiplantae) include around 450,000–500,000 species1, 2 of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life