The Density of Lyman-alpha Emitters at Very High Redshift

We describe narrowband and spectroscopic searches for emission-line star forming galaxies in the redshift range 3 to 6 with the 10 m Keck II Telescope. These searches yield a substantial population of objects with only a single strong (equivalent width >> 100 Angstrom) emission line, lying in the 4000 - 10,000 Angstrom range. Spectra of the objects found in narrowband-selected samples at lambda ~5390 Angstroms and ~6741 Angstroms show that these very high equivalent width emission lines are generally redshifted Lyman alpha 1216 Angstrom at z~3.4 and 4.5. The density of these emitters above the 5 sigma detection limit of 1.5 e-17 ergs/cm^2/s is roughly 15,000 per square degree per unit redshift interval at both z~3.4 and 4.5. A complementary deeper (1 sigma \~1.0 e-18 ergs/cm^2/s) slit spectroscopic search covering a wide redshift range but a more limited spatial area (200 square arcminutes) shows such objects can be found over the redshift range 3 to 6, with the currently highest redshift detected being at z=5.64. The Lyman alpha flux distribution can be used to estimate a minimum star formation rate in the absence of reddening of roughly 0.01 solar masses/Mpc^3/year (H_0 = 65 km/s/Mpc and q_0 = 0.5). Corrections for reddening are likely to be no larger than a factor of two, since observed equivalent widths are close to the maximum values obtainable from ionization by a massive star population. Within the still significant uncertainties, the star formation rate from the Lyman alpha-selected sample is comparable to that of the color-break-selected samples at z~3, but may represent an increasing fraction of the total rates at higher redshifts. This higher-z population can be readily studied with large ground-based telescopes.Comment: 7 pages, 5 encapsulated figures; aastex, emulateapj, psfig and lscape style files. Separate gif files for 2 gray-scale images also available at http://www.ifa.hawaii.edu/faculty/hu/emitters.html . Added discussion of foreground contaminants. Updated discussion of comparison with external surveys (Sec. 5 and Fig. 5). Note: continuum break strength limits (Fig. 3 caption) are correct here -- published ApJL text has a sign erro

Caltech Faint Galaxy Redshift Survey X: A Redshift Survey in the Region of the Hubble Deep Field North

A redshift survey has been carried out in the region of the Hubble Deep Field North using the Low Resolution Imaging Spectrograph at the Keck Observatory. The resulting redshift catalog, which contains 671 entries, is a compendium of our own data together with published LRIS/Keck data. It is more than 92% complete for objects, irrespective of morphology, to $R = 24$ mag in the HDF itself and to $R = 23$ mag in the Flanking Fields within a diameter of 8 arcmin centered on the HDF, an unusually high completion for a magnitude limited survey performed with a large telescope. A median redshift $z = 1.0$ is reached at $R \sim 23.8$. Strong peaks in the redshift distribution, which arise when a group or poor cluster of galaxies intersect the area surveyed, can be identified to $z \sim 1.2$ in this dataset. More than 68% of the galaxies are members of these redshift peaks. In a few cases, closely spaced peaks in $z$ can be resolved into separate groups of galaxies that can be distinguished in both velocity and location on the sky. The radial separation of these peaks in the pencil-beam survey is consistent with a characteristic length scale for the their separation of $\approx$70 Mpc in our adopted cosmology ($h = 0.6, \Omega_M = 0.3$, $\Lambda = 0$). Strong galaxy clustering is in evidence at all epochs back to $z \le 1.1$. (abstract abridged)Comment: Accepted to the ApJ. This version contains all the figures and tables. 2 minor typos in table 2b correcte

How should we incentivize private landowners to "produce" more biodiversity?

Globally, much biodiversity is found on private land. Acting to conserve such biodiversity thus requires the design of policies which influence the decision-making of farmers and foresters. In this paper, we outline the economic characteristics of this problem, before reviewing a number of policy options such as conservation auctions and conservation easements. We then discuss a number of policy design problems, such as need for spatial coordination and the choice between paying for outcomes rather than actions, before summarizing what the evidence and theory developed to date tells us about those aspects of biodiversity policy design which need careful attention from policy makers and environmental regulators

The General Practice Care of People With Intellectual Disability: Barriers and Solutions

A questionnaire exploring general practitioners' (GPs) perceptions of the barriers and solutions to providing health care to people with intellectual disability was sent to 912 randomly selected GPs throughout Australia. a response rate of 58% was obtained. Results indicated that numerous barriers compromised the quality of health care able to be provided to people with intellectual disability. communications difficulties with patients and other health professionals, and problems in obtaining patient histories stood out as the two most significant barriers. A range of other barriers were identified, including GPs' lack of training and experience, patients' poor compliance with management plans, consultation time constraints, difficulties in problem determination, examination difficulties, poor continuity of care, and GPs' inadequate knowledge of the services and resources available. General practitioners also suggested numerous solutions to these barriers, and emphasized the need for increased opportunities for education and training in intellectual disability. The GPs showed an overwhelming interest to be involved in further education. Other major solutions included increasing consultation duration or frequency, proactively involving families and carers in patients' ongoing health care, and increasing remuneration

Using directed acyclic graphs in epidemiological research in psychosis:an analysis of the role of bullying in psychosis

Modern psychiatric epidemiology researches complex interactions between multiple variables in large datasets. This creates difficulties for causal inference. We argue for the use of probabilistic models represented by directed acyclic graphs (DAGs). These capture the dependence structure of multiple variables and, used appropriately, allow more robust conclusions about the direction of causation. We analyzed British national survey data to assess putative mediators of the association between bullying victimization and persecutory ideation. We compared results using DAGs and the Karlson-Holm-Breen (KHB) logistic regression commands in STATA. We analyzed data from the 2007 English National Survey of Psychiatric Morbidity, using the equivalent 2000 survey in an instant replication. Additional details of methods and results are provided in the supplementary material. DAG analysis revealed a richer structure of relationships than could be inferred using the KHB logistic regression commands. Thus, bullying had direct effects on worry, persecutory ideation, mood instability, and drug use. Depression, sleep and anxiety lay downstream, and therefore did not mediate the link between bullying and persecutory ideation. Mediation by worry and mood instability could not be definitively ascertained. Bullying led to hallucinations indirectly, via persecutory ideation and depression. DAG analysis of the 2000 dataset suggested the technique generates stable results. While causality cannot be fully determined from cross-sectional data, DAGs indicate the relationships providing the best fit. They thereby advance investigation of the complex interactions seen in psychiatry, including the mechanisms underpinning psychiatric symptoms. It may consequently be used to optimize the choice of intervention targets.</p

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2\u27-O-Methyl (2\u27OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2\u27OMe AMOs to inhibit Toll-like receptor (TLR) 7 and 8 sensing of immunostimulatory RNA, independent of their miRNA-targeting function. Through a screen of 29 AMOs targeting common miRNAs, we found a subset of sequences highly inhibitory to TLR7 sensing in mouse macrophages. Interspecies conservation of this inhibitory activity was confirmed on TLR7/8 activity in human peripheral blood mononuclear cells. Significantly, we identified a core motif governing the inhibitory activity of these AMOs, which is present in more than 50 AMOs targeted to human miRNAs in miRBaseV20. DNA/locked nucleic acids (LNA) AMOs synthesized with a phosphorothioate backbone also inhibited TLR7 sensing in a sequence-dependent manner, demonstrating that the off-target effects of AMOs are not restricted to 2\u27OMe modification. Taken together, our work establishes the potential for off-target effects of AMOs on TLR7/8 function, which should be taken into account in their therapeutic development and in vivo application