The Life-Cycle Income Analysis Model (LIAM): a study of a flexible dynamic microsimulation modelling computing framework

This paper describes a flexible computing framework designed to create a dynamic microsimulation model, the Life-cycle Income Analysis Model (LIAM). The principle computing characteristics include the degree of modularisation, parameterisation, generalisation and robustness. The paper describes the decisions taken with regard to type of dynamic model used. The LIAM framework has been used to create a number of different microsimulation models, including an Irish dynamic cohort model, a spatial dynamic microsimulation model for Ireland, an indirect tax and consumption model for EU15 as part of EUROMOD and a prototype EU dynamic population microsimulation model for 5 EU countries. Particular consideration is given to issues of parameterisation, alignment and computational efficiency.flexible; modular; dynamic; alignment; parameterisation; computational efficiency

Alien Registration- Lennon, Stephen E. (Fort Fairfield, Aroostook County)

https://digitalmaine.com/alien_docs/36513/thumbnail.jp

Absolute linear instability in laminar and turbulent gas/liquid two-layer channel flow

We study two-phase stratified flow where the bottom layer is a thin laminar liquid and the upper layer is a fully-developed gas flow. The gas flow can be laminar or turbulent. To determine the boundary between convective and absolute instability, we use Orr--Sommerfeld stability theory, and a combination of linear modal analysis and ray analysis. For turbulent gas flow, and for the density ratio r=1000, we find large regions of parameter space that produce absolute instability. These parameter regimes involve viscosity ratios of direct relevance to oil/gas flows. If, instead, the gas layer is laminar, absolute instability persists for the density ratio r=1000, although the convective/absolute stability boundary occurs at a viscosity ratio that is an order of magnitude smaller than in the turbulent case. Two further unstable temporal modes exist in both the laminar and the turbulent cases, one of which can exclude absolute instability. We compare our results with an experimentally-determined flow-regime map, and discuss the potential application of the present method to non-linear analyses.Comment: 33 pages, 20 figure

ForgetMeNot: Active Reminder Entry Support for Adults with Acquired Brain Injury

Smartphone reminding apps can compensate for memory impairment after acquired brain injury (ABI). In the absence of a caregiver, users must enter reminders themselves if the apps are going to help them. Poor memory and apathy associated with ABI can result in failure to initiate such configuration behaviour and the benefits of reminder apps are lost. ForgetMeNot takes a novel approach to address this problem by periodically encouraging the user to enter reminders with unsolicited prompts (UPs). An in situ case study investigated the experience of using a reminding app for people with ABI and tested UPs as a potential solution to initiating reminder entry. Three people with severe ABI living in a post-acute rehabilitation hospital used the app in their everyday lives for four weeks to collect real usage data. Field observations illustrated how difficulties with motivation, insight into memory difficulties and anxiety impact reminder app use in a rehabilitation setting. Results showed that when 6 UPs were presented throughout the day, reminder-setting increased, showing UPs are an important addition to reminder applications for people with ABI. This study demonstrates that barriers to technology use can be resolved in practice when software is developed with an understanding of the issues experienced by the user group

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma

Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is important for local tumour control, however, radioresistance remains a substantial clinical problem. We hypothesise that alterations in mitochondrial function and energy metabolism are involved in the radioresistance of oesophageal adenocarcinoma (OAC). To investigate this, we used an established isogenic cell line model of radioresistant OAC. Radioresistant cells (OE33 R) demonstrated significantly increased levels of random mitochondrial mutations, which were coupled with alterations in mitochondrial function, size, morphology and gene expression, supporting a role for mitochondrial dysfunction in the radioresistance of this model. OE33 R cells also demonstrated altered bioenergetics, demonstrating significantly increased intracellular ATP levels, which was attributed to enhanced mitochondrial respiration. Radioresistant cells also demonstrated metabolic plasticity, efficiently switching between the glycolysis and oxidative phosphorylation energy metabolism pathways, which were accompanied by enhanced clonogenic survival. This data was supported in vivo, in pre-treatment OAC tumour tissue. Tumour ATP5B expression, a marker of oxidative phosphorylation, was significantly increased in patients who subsequently had a poor pathological response to neoadjuvant CRT. This suggests for the first time, a role for specific mitochondrial alterations and metabolic remodelling in the radioresistance of OAC

Technological memory aid use by people with acquired brain injury

Evans, Wilson, Needham, and Brentnall (2003) investigated memory aid use by people with acquired brain injury (ABI) and found little use of technological memory aids. The present study aims to investigate use of technological and other memory aids and strategies 10 years on, and investigate what predicts use. People with ABI and self-reported memory impairments (n = 81) completed a survey containing a memory aid checklist, demographic questions and memory questionnaires. Chi-square analysis showed that 10 of 18 memory aids and strategies were used by significantly more people in the current sample than in Evans et al. (2003). The most commonly used strategies were leaving things in noticeable places (86%) and mental retracing of steps (77%). The most commonly used memory aids were asking someone to remind you (78%), diaries (77%), lists (78%), and calendars (79%) and the most common technologies used were mobile phone reminders (38%) and alarms/timers (38%). Younger people who used more technology prior to their injury and who use more non-technological memory aids currently were more likely to use technology. Younger people who used more memory aids and strategies prior to their injury and who rated their memory as poorer were more likely to use all types of memory aids and strategies

Desert island data: an investigation into researcher positionality

The nature of qualitative research means that the personal values of an individual researcher can and do (unwittingly) shape the way in which they analyse data sets, and the resultant conclusions drawn. However this phenomenon is under-studied in social research: this article seeks to help rectify this. It presents findings from a small research project focused on discourses of class, masculinity, and work among British male comedians from working-class backgrounds, interviewed on the popular BBC Radio 4 radio programme Desert Island Discs. Six different researchers, from varying disciplinary, methodological, and theoretical groundings, as well as from varying personal backgrounds, analysed three interview recordings and transcripts separately. All the researchers wrote up their individual analyses of these interviews and wrote reflexive pieces examining why they thought they approached the data as they did. The researchers then came together as a group to compare and contrast findings and approaches. The results from this study, including the discrepancies and distinctions and final group analysis, are reported alongside a thorough discussion of the project's methodology. We find that the project evidenced how a diverse research team can bring out deeper and richer analyses, and was a refreshing way to try and answer questions of individual and collective positionalit

Denitrification by sulfur-oxidizing bacteria in a eutrophic lake

Understanding the mechanistic controls of microbial denitrification is of central importance to both environmental microbiology and ecosystem ecology. Loss of nitrate (NO3 −) is often attributed to carbon-driven (heterotrophic) denitrification. However, denitrification can also be coupled to sulfur (S) oxidation by chemolithoautotrophic bacteria. In the present study, we used an in situ stable isotope (15NO3 −) tracer addition in combination with molecular approaches to understand the contribution of sulfur-oxidizing bacteria to the reduction of NO3 − in a eutrophic lake. Samples were incubated across a total dissolved sulfide (H2S) gradient (2 to 95 μM) between the lower epilimnion and the upper hypolimnion. Denitrification rates were low at the top of the chemocline (4.5 m) but increased in the deeper waters (5.0 and 5.5 m), where H2S was abundant. Concomitant with increased denitrification at depths with high sulfide was the production of sulfate (SO4 2−), suggesting that the added NO3 − was used to oxidize H2S to SO4 2−. Alternative nitrate removal pathways, including dissimilatory nitrate reduction to ammonium (DNRA) and anaerobic ammonium oxidation (anammox), did not systematically change with depth and accounted for 1 to 15% of the overall nitrate loss. Quantitative PCR revealed that bacteria of the Sulfurimonas genus that are known denitrifiers increased in abundance in response to NO3 − addition in the treatments with higher H2S. Stoichiometric estimates suggest that H2S oxidation accounted for more than half of the denitrification at the depth with the highest sulfide concentration. The present study provides evidence that microbial coupling of S and nitrogen (N) cycling is likely to be important in eutrophic freshwater ecosystems

Technology to encourage meaningful activities following brain injury

Background: Cognitive and behavioural difficulties after acquired brain injury (ABI) may lead to reduced engagement in leisure and social activities. Increasing participation is a goal of neuropsychological rehabilitation and assistive and behaviour change technology can play an important role in this. Focus groups and interviews were conductive with brain injury rehabilitation stakeholders (n = 24): people with ABI (n = 9), family members (n = 3) and care providers (n = 12) in order to understand the barriers to engaging in meaningful activities and what helps to overcome these barriers. A collaborative thematic analysis was performed by a multi-disciplinary research team using an approach based on Grounded Theory. Results: Four central, interlinked, barriers were found: Access, Cognitive Difficulties, Anticipation (of Physical or Cognitive Difficulties) and Motivation. To overcome these barriers, participants cited themes such as External Motivation from both Other People and Technology, Maintaining Momentum and different aspects of Being Planful. Conclusions: The results point to future directions for the purposeful development of effective assistive technology for this user group. Technology that is social, persuasive, adapts to individual needs and supports people to plan activities are likely to be particularly useful within neuropsychological rehabilitation. Implications For Rehabilitation: Adults with ABI and their carers describe problems accessing activities, cognitive difficulties, anticipationof physical or cognitive difficulties and low motivation as the key barriers to undertaking meaningfulactivities. Current solutions are external prompting, maintaining momentum and being planful. This detailed qualitative analysis of a diverse group of carers and service users allows insight into theassistive technologies that could aid rehabilitation