Building Scalable Cyber-Physical-Social Networking Infrastructure Using IoT and Low Power Sensors

Wireless Sensors are an important component to develop the Internet of Things (IoT) Sensing infrastructure. There are enormous numbers of sensors connected with each other to form a network (well known as wireless sensor networks) to complete IoT Infrastructure. These deployed wireless sensors are with limited energy and processing capabilities. IoT infrastructure becomes a key factor to building cyber-physical-social networking infrastructure, where all these sensing devices transmit data towards the cloud data center. Data routing towards cloud data center using such low power sensor is still a challenging task. In order to prolong the lifetime of the IoT sensing infrastructure and building scalable cyber infrastructure, there is the requirement of sensing optimization and energy efficient data routing. Towards addressing these issues of IoT sensing, this paper proposes a novel rendezvous data routing protocol for low power sensors. The proposed method divides the sensing area into a number of clusters to lessen the energy consumption with data accumulation and aggregation. As a result, there will be less amount of data stream to the network. Another major reason to select cluster-based data routing is to reduce the control overhead. Finally, the simulation of the proposed method is done in the Castalia simulator to observe the performance. It has been concluded that the proposed method is energy efficient and it prolongs the networks lifetime for scalable IoT infrastructure

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

TCloud: Cloud SDI model for tourism information infrastructure management

This chapter proposes and develops a cloud-computing-based SDI model named as TCloud for sharing, analysis, and processing of spatial data particularly in the Temple City of India, Bhubaneswar. The main purpose of TCloud is to integrate all the spatial information such as tourism sites which include various temples, mosques, churches, monuments, lakes, mountains, rivers, forests, etc. TCloud can help the decision maker or planner or common users to get enough information for their further research and studies. It has used open source GIS quantum GIS for the development of spatial database whereas QGIS plugin has been linked with quantum GIS for invoking cloud computing environment. It has also discussed the various spatial overlay analysis in TCloud environment

Cluster-Based Routing Protocol with Static Hub (CRPSH) for WSN-Assisted IoT Networks

The Internet of Things (IoT) is an evolving concept that has achieved prominence in the modern era. An autonomous sensor-equipped device is the major component of WSN-assisted IoT infrastructure. These devices intelligently sense the environment, automatically collect the data, and deliver the information to paired devices. However, in WSN-assisted IoT networks, energy depletion and hardware faults might result in device failures. Additionally, this might affect data transmission. A reliable route significantly reduces data retransmissions, which can help in congestion reduction and energy conservation. Generally, the sensor devices are typically deployed densely throughout the WSN-assisted IoT networks. A high number of sensor devices covering a monitoring area might result in duplicate data. The clustering method can be used to overcome this problem. The clustering technique reduces network traffic, whereas the multipath technique ensures path reliability. In CRPSH, we used the clustering technique to reduce the duplicate data. Moreover, the multipath approach can increase the reliability of the proposed protocol. CRPSH is intended to minimize the overhead associated with control packets and extend the network’s lifetime. The complete set of simulations is carried out using the Castalia simulator. The proposed protocol is found to reduce energy consumption and increase the lifetime of IoT infrastructure networks

Hybrid mist-cloud systems for large scale geospatial big data analytics and processing: opportunities and challenges

The cloud and fog computing paradigms are developing area for storing, processing, and analysis of geospatial big data. Latest trend is mist computing which boost fog and cloud concepts for computing process where edge devices are used to help increase throughput and reduce latency to support at client edge. The present research article discussed the mist computing emergence for geospatial analysis of data from various geospatial applications. It also created a framework based on mist computing, i.e., MistGIS for analytics in mining domain from geospatial big data. The developed MistGIS platform is used in Tourism Information Infrastructure Management and Faculty Information Retrial System. Tourism Information Infrastructure Management is to assimilate entire geospatial data in context to travel/tourism places constitute of various lakes, mountains, rivers, forests, temples, mosques, churches, monuments, etc. It can aid all the stakeholders or users to acquire sufficient data in subsequent research studies. In this study, it has taken the Temple City of India, Bhubaneswar as the case study. Whereas Faculty Information Retrial System facilitated many functionalities with respect to finding the detail information of faculties according to their research area, contact details, and email ids, etc in all 31 National Institutes of Technology (NITs) in India. The framework is built with the Raspberry Pi microprocessor. The MistGIS platform has been confirmed by prelude analysis which includes cluster and overlay. The outcome show that mist computing assist cloud and fog computing to provide the analysis of geospatial big data

BCGeo: Blockchain-Assisted Geospatial Web Service for Smart Healthcare System

Most recent research on healthcare systems has focused on integrating the Internet of Things (IoT), Blockchain technology, and cloud computing to enhance the performance of IoT devices with limited resource availability, create smart healthcare platforms, and offer patients the best possible healthcare service. Modern healthcare systems use large-scale sensor devices to address many challenges brought on by the conventional delivery of healthcare services. Most studies have lately identified data collection, massive data processing, geolocating, access management, device prioritization, and storing as primary issues in most IoT healthcare systems. Decentralization, privacy, security, scalability, trust, anonymity, and building geospatial-based intelligent healthcare systems for patient care are significant difficulties that most healthcare systems today must overcome. Blockchain technology in healthcare platforms is noteworthy and innovative since it opens platforms for data privacy, anonymity, and validity through the consensus process. In this work, we proposed a novel decentralized Blockchain-enabled geospatial service architecture for smart healthcare systems called BCGeo. The proposed framework offers an online geospatial healthcare service for residents of Bhubaneswar, a city in India, who are newcomers to the city and are less familiar with its local healthcare organizations. An analytical queueing method prioritizes serving Critical patients more than other patients. In contrast to previously proposed frameworks, the proposed framework includes immutability, scalability, geospatial mapping, patient prioritizing, and decentralized privacy protection policies for addressing the technical challenges in most of the current healthcare systems. Additionally, it explains the performance analysis of BCGeo. It includes graphs showing the various possible outcomes of arithmetic operations, performance measurement, and experimental results on the proposed architecture

MistGIS: optimizing geospatial data analysis using mist computing

Geospatial data analysis with the help of cloud and fog computing is one of the emerging areas for processing, storing, and analysis of geospatial data. Mist computing is also one of the paradigms where fog devices help to reduce the latency period and increase throughput for assisting at the near of edge device of the client. It discusses the emergence of mist computing for mining analytics in geospatial big data from geospatial application. This paper developed a mist computing-based framework for mining analytics from geospatial big data. We developed MistGIS framework for Ganga River Management System using mist computing. It built a prototype using Raspberry Pi, an embedded microprocessor. The developed MistGIS framework has validated by doing preliminary analysis including K-means clustering and overlay analysis. The results showed that mist computing can assist the fog and cloud computing hold an immense promise for analysis of big data in geospatial application particularly in the management of Ganga River Basin

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders

Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791

The value of open-source clinical science in pandemic response: lessons from ISARIC

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