7,524 research outputs found
Open Knowledge Report (2017-2018)
IUPUI University Library's Open Knowledge Report (2017-2018).This report includes all Wikimedia-related activities from January 1st, 2017 to December 31, 2018. It covers events hosted at IUPUI University Library and the Ruth Lilly Medical Library, and projects focused on making our archival collections, library-hosted publications, and the scholarly output of our faculty members more accessible. In addition, it includes a list of relevant publications as well as presentations given at various conferences as a way of sharing ongoing efforts and increasing awareness of Open Knowledge projects
Necessary Reconstruction: The Child Welfare System
This research has been composed of both primary and secondary research aimed to shine light on the most pressing issues within the child welfare system. It not only demonstrates the detrimental tolls the system has had on the children but also the tolls it has had on the public servants working within the system. This research is a gateway to awareness of the realities and necessary changes the system so desperately needs
Inferring phylogenetic networks with maximum pseudolikelihood under incomplete lineage sorting
Phylogenetic networks are necessary to represent the tree of life expanded by
edges to represent events such as horizontal gene transfers, hybridizations or
gene flow. Not all species follow the paradigm of vertical inheritance of their
genetic material. While a great deal of research has flourished into the
inference of phylogenetic trees, statistical methods to infer phylogenetic
networks are still limited and under development. The main disadvantage of
existing methods is a lack of scalability. Here, we present a statistical
method to infer phylogenetic networks from multi-locus genetic data in a
pseudolikelihood framework. Our model accounts for incomplete lineage sorting
through the coalescent model, and for horizontal inheritance of genes through
reticulation nodes in the network. Computation of the pseudolikelihood is fast
and simple, and it avoids the burdensome calculation of the full likelihood
which can be intractable with many species. Moreover, estimation at the
quartet-level has the added computational benefit that it is easily
parallelizable. Simulation studies comparing our method to a full likelihood
approach show that our pseudolikelihood approach is much faster without
compromising accuracy. We applied our method to reconstruct the evolutionary
relationships among swordtails and platyfishes (: Poeciliidae),
which is characterized by widespread hybridizations
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MacroSight: A novel framework to analyze the shape and movement of interacting macrophages using MAtLABR â€
This paper presents a novel software framework, called macrosight, which incorporates routines to detect, track, and analyze the shape and movement of objects, with special emphasis on macrophages. The key feature presented in macrosight consists of an algorithm to assess the changes of direction derived from cell-cell contact, where an interaction is assumed to occur. The main biological motivation is the determination of certain cell interactions influencing cell migration. Thus, the main objective of this work is to provide insights into the notion that interactions between cell structures cause a change in orientation. Macrosight analyzes the change of direction of cells before and after they come in contact with another cell. Interactions are determined when the cells overlap and form clumps of two or more cells. The framework integrates a segmentation technique capable of detecting overlapping cells and a tracking framework into a tool for the analysis of the trajectories of cells before and after they overlap. Preliminary results show promise into the analysis and the hypothesis proposed, and lays the groundwork for further developments. The extensive experimentation and data analysis show, with statistical significance, that under certain conditions, the movement changes before and after an interaction are different from movement in controlled cases
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