1,008 research outputs found
Scanning Tunneling Spectroscopy of Suspended Single-Wall Carbon Nanotubes
We have performed low-temperature STM measurements on single-wall carbon
nanotubes that are freely suspended over a trench. The nanotubes were grown by
CVD on a Pt substrate with predefined trenches etched into it. Atomic
resolution was obtained on the freestanding portions of the nanotubes.
Spatially resolved spectroscopy on the suspended portion of both metallic and
semiconducting nanotubes was also achieved, showing a Coulomb-staircase
behavior superimposed on the local density of states. The spacing of the
Coulomb blockade peaks changed with tip position reflecting a changing tip-tube
capacitance
Tracking advanced persistent threats in critical infrastructures through opinion dynamics
Advanced persistent threats pose a serious issue for modern industrial environments, due to their targeted and complex attack vectors that are difficult to detect. This is especially severe in critical infrastructures that are accelerating the integration of IT technologies. It is then essential to further develop effective monitoring and response systems that ensure the continuity of business to face the arising set of cyber-security threats. In this paper, we study the practical applicability of a novel technique based on opinion dynamics, that permits to trace the attack throughout all its stages along the network by correlating different anomalies measured over time, thereby taking the persistence of threats and the criticality of resources into consideration. The resulting information is of essential importance to monitor the overall health of the control system and cor- respondingly deploy accurate response procedures. Advanced Persistent Threat Detection Traceability Opinion Dynamics.Universidad de Málaga. Campus de Excelencia Internacional AndalucÃa Tech
Gene regulatory networks in lactation: identification of global principles using bioinformatics
<p>Abstract</p> <p>Background</p> <p>The molecular events underlying mammary development during pregnancy, lactation, and involution are incompletely understood.</p> <p>Results</p> <p>Mammary gland microarray data, cellular localization data, protein-protein interactions, and literature-mined genes were integrated and analyzed using statistics, principal component analysis, gene ontology analysis, pathway analysis, and network analysis to identify global biological principles that govern molecular events during pregnancy, lactation, and involution.</p> <p>Conclusion</p> <p>Several key principles were derived: (1) nearly a third of the transcriptome fluctuates to build, run, and disassemble the lactation apparatus; (2) genes encoding the secretory machinery are transcribed prior to lactation; (3) the diversity of the endogenous portion of the milk proteome is derived from fewer than 100 transcripts; (4) while some genes are differentially transcribed near the onset of lactation, the lactation switch is primarily post-transcriptionally mediated; (5) the secretion of materials during lactation occurs not by up-regulation of novel genomic functions, but by widespread transcriptional suppression of functions such as protein degradation and cell-environment communication; (6) the involution switch is primarily transcriptionally mediated; and (7) during early involution, the transcriptional state is partially reverted to the pre-lactation state. A new hypothesis for secretory diminution is suggested – milk production gradually declines because the secretory machinery is not transcriptionally replenished. A comprehensive network of protein interactions during lactation is assembled and new regulatory gene targets are identified. Less than one fifth of the transcriptionally regulated nodes in this lactation network have been previously explored in the context of lactation. Implications for future research in mammary and cancer biology are discussed.</p
Smoke-Free Policy in Vermont Public Housing Authorities
Introduction. Millions of adults and children living in public housing face exposure to second hand smoke from adjacent apartments. These tenants are less able to escape smoke exposure by moving, and Housing Authorities are beginning to implement smoke-free policies. We assessed the status of smoke-free policy in Vermont public housing, and explored the experience of tenants and managers in Burlington who recently implemented such a policy.https://scholarworks.uvm.edu/comphp_gallery/1080/thumbnail.jp
Quantum Interference Effects in Electronic Transport through Nanotube Contacts
Quantum interference has dramatic effects on electronic transport through
nanotube contacts. In optimal configuration the intertube conductance can
approach that of a perfect nanotube (). The maximum conductance
increases rapidly with the contact length up to 10 nm, beyond which it exhibits
long wavelength oscillations. This is attributed to the resonant cavity-like
interference phenomena in the contact region. For two concentric nanotubes
symmetry breaking reduces the maximum intertube conductance from to
. The phenomena discussed here can serve as a foundation for building
nanotube electronic circuits and high speed nanoscale electromechanical
devices
Convective Term and Transversely Driven Charge-Density Waves
We derive the convective terms in the damping which determine the structure
of the moving charge-density wave (CDW), and study the effect of a current
flowing transverse to conducting chains on the CDW dynamics along the chains.
In contrast to a recent prediction we find that the effect is orders of
magnitude smaller, and that contributions from transverse currents of electron-
and hole-like quasiparticles to the force exerted on the CDW along the chains
act in the opposite directions. We discuss recent experimental verification of
the effect and demonstrate experimentally that geometry effects might mimic the
transverse current effect.Comment: RevTeX, 9 pages, 1 figure, accepted for publications in PR
Viscoelastic Depinning of Driven Systems: Mean-Field Plastic Scallops
We have investigated the mean field dynamics of an overdamped viscoelastic
medium driven through quenched disorder. The model introduced incorporates
coexistence of pinned and sliding degrees of freedom and can exhibit continuous
elastic depinning or first order hysteretic depinning. Numerical simulations
indicate mean field instabilities that correspond to macroscopic stick-slip
events and lead to premature switching. The model is relevant for the dynamics
of driven vortex arrays in superconductors and other extended disordered
systems.Comment: 4 pages, 2 figure
Understanding the errors of SHAPE-directed RNA structure modeling
Single-nucleotide-resolution chemical mapping for structured RNA is being
rapidly advanced by new chemistries, faster readouts, and coupling to
computational algorithms. Recent tests have shown that selective 2'-hydroxyl
acylation by primer extension (SHAPE) can give near-zero error rates (0-2%) in
modeling the helices of RNA secondary structure. Here, we benchmark the method
using six molecules for which crystallographic data are available: tRNA(phe)
and 5S rRNA from Escherichia coli, the P4-P6 domain of the Tetrahymena group I
ribozyme, and ligand-bound domains from riboswitches for adenine, cyclic
di-GMP, and glycine. SHAPE-directed modeling of these highly structured RNAs
gave an overall false negative rate (FNR) of 17% and a false discovery rate
(FDR) of 21%, with at least one helix prediction error in five of the six
cases. Extensive variations of data processing, normalization, and modeling
parameters did not significantly mitigate modeling errors. Only one varation,
filtering out data collected with deoxyinosine triphosphate during primer
extension, gave a modest improvement (FNR = 12%, and FDR = 14%). The residual
structure modeling errors are explained by the insufficient information content
of these RNAs' SHAPE data, as evaluated by a nonparametric bootstrapping
analysis. Beyond these benchmark cases, bootstrapping suggests a low level of
confidence (<50%) in the majority of helices in a previously proposed
SHAPE-directed model for the HIV-1 RNA genome. Thus, SHAPE-directed RNA
modeling is not always unambiguous, and helix-by-helix confidence estimates, as
described herein, may be critical for interpreting results from this powerful
methodology.Comment: Biochemistry, Article ASAP (Aug. 15, 2011
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