11 research outputs found
Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation
[no abstract available
Notch signaling controls liver development by regulating biliary differentiation
In the mammalian liver, bile is transported to the intestine through an
intricate network of bile ducts. Notch signaling is required for normal duct
formation, but its mode of action has been unclear. Here, we show in mice that
bile ducts arise through a novel mechanism of tubulogenesis involving
sequential radial differentiation. Notch signaling is activated in a subset of
liver progenitor cells fated to become ductal cells, and pathway activation is
necessary for biliary fate. Notch signals are also required for bile duct
morphogenesis, and activation of Notch signaling in the hepatic lobule
promotes ectopic biliary differentiation and tubule formation in a
dose-dependent manner. Remarkably, activation of Notch signaling in postnatal
hepatocytes causes them to adopt a biliary fate through a process of
reprogramming that recapitulates normal bile duct development. These results
reconcile previous conflicting reports about the role of Notch during liver
development and suggest that Notch acts by coordinating biliary
differentiation and morphogenesis
Bile duct development occurs via a new mode of tubulogenesis involving TGF-beta
info:eu-repo/semantics/nonPublishe
Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.
A number of diseases are characterized by defective formation of the intrahepatic bile ducts. In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9).Comparative StudyJournal ArticleResearch Support, N.I.H. ExtramuralResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe
A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.
International audienceno abstrac