Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial

In the BIG 1-98 clinical trial of 4922 postmenopausal women treated with 5 years of letrozole or tamoxifen for endocrine-responsive breast cancer, 183 had the rare histotypes mucinous or tubular/cribriform. These women had better outcomes than those with other histotypes. The magnitude of the letrozole advantage compared with tamoxifen may not be as large in patients with these rare histotype

Risk profiling based on p16 and HPV DNA more accurately predicts location of disease relapse in patients with oropharyngeal squamous cell carcinoma

Background: In the era of precision medicine and HPV-related oropharyngeal squamous cell carcinoma (OPSCC), it is relevant to assess the risk of not only survival, but also the risk of local, regional, or distant treatment failure. The UICC 8th edition uses the surrogate marker p16 to stratify for HPV association but discordance between p16 status and HPV association has been shown. The purpose of this study was to develop a prognostic model to predict the risk of local, regional, and distant metastases and non-cancer-related death for patients with OPSCC, test the prognostic relevance of adding HPV DNA and p16 status, and validate the findings in an independent external dataset. Patients and methods: Consecutive patients diagnosed with OPSCC and treated with curative radiotherapy with or without cisplatin in eastern Denmark from 2000 to 2014 were included. Characteristics included age, gender, TNM stage, smoking habits, performance status, and HPV status assessed with p16 and HPV DNA. The information was used to develop a prognostic model for first site of failure with four competing events: recurrence in T-, N-, and M-site, and death with no evidence of disease. Results: Overall 1243 patients were eligible for the analysis. A prognostic model with the four events was developed and externally validated in an independent dataset with a heterogeneously treated patient population from another institution. The individual prognostication from the competing risk analysis is displayed in a user friendly online tool (https://rasmussen.shinyapps.io/OPSCCmodelHPV_p16/). Replacing p16 status with the combined variable HPV/p16 status influenced the HR and patients with HPV-/p16+ had significantly higher HR of M-site recurrence than HPV+/p16+ with a HR = 2.56; CI [1.30; 5.02]; P = 0.006 (P = 0.013 in the validation cohort). Conclusion: Patients with HPV-/p16+ have significantly higher risk of M-site recurrence and could potentially be relevant candidates for clinical trials testing systemic treatments in combination with conventional treatments

3. Kolloquium Laserstrahl-Handbearbeitung

Dieser Tagungsband enthaelt 10 Beitraege mit folgenden Themen: Handgefuehrte Lasersysteme fuer die cw- und pw-Laser-Materialbearbeitung; Moeglichkeiten der Laserstrahl-Handbearbeitung im Schiffbau; Spezifische Anforderungen an die Laserstrahl-Handbearbeitung; Neue Loesungsansaetze in der Sicherheitstechnik fuer Handlaser; Moeglichkeiten der Prozessintegration von mobilen Laserhandschweisssystemen in Industrie und Handwerk; Automatisierung von Handarbeitsplaetzen; Einsatzmoeglichkeit moderner mobiler Nd:YAG-Laser; Der Laser-Handarbeitsplatz im Werkzeug- und Formenbau; Normungsarbeit fruehandgefuehrte und handpositionierte Systeme; Technik und Anwendungen fuer das manuelle Auftragsschweissen.The proceedings volume contains 10 papers on the following subjects: Manual laser systems for cw and pw laser finishing; Manual finishing in marine engineering; Specific requirements on manual laer finishing; New solutions for better safety in manual laser finishing; Process integration of mobile laser welding systems in industry and trade; Automation of manual laser finishing; Modern mobile Nd:YAG lasers; Manual laser finishing in tool production and mould making; Standards for hand-held and hand-positioned laser systems; Technology and applications of manual hardfacing.SIGLEAvailable from TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman