Queer feminist international relations: uneasy alliances, productive tensions

This article examines the ‘uneasy alliance’ between Feminist IR and Queer IR. The article focusses on three areas of tension and continuity between the fields: (1) sexuality, sexual deviance and gender variance; (2) the roles of liberalism in gendered, sexualized and racialized violence; and (3) binaries relating to sex, gender and sexuality. The article argues that it is around tensions between Queer and Feminist IR that a Queer Feminist IR can be productively articulated. In particular, a Queer Feminist IR should: centre women and femmes as well as sexuality and gender variance; disrupt of binaries and fixed identities without losing the political leverage that sometimes comes with them; and acknowledge entanglements with the institutions Feminist and Queer IR seek to transform while also resisting being neutralized by assimilation

Gendered and sexualized figurations of security

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Post-liberal agency: decolonizing politics and universities in the Canadian Arctic

In this thesis I theorize possibilities for post-liberal forms of political agency. Actors seeking to resist, refuse or rework liberalisms’ myths and violence are faced with a paradox. How to act against or in-spite-of the terms of political action themselves? Engagement with liberal narratives of political agency risks simply repeating their logics. Refusals of those logics risk being erased by them, if such a refusal is even possible. There seems to be little room for agency either way. This problem is further complicated by liberalisms’ diverse local contingencies and, nonetheless, the persistence of liberal political rationalities across contexts. Monolithic accounts of liberalisms buy into their universalizing logics. Approaching liberalisms as endlessly adaptable and malleable, however, misses their significance across contexts and echoes liberal voluntarism. Turning from agency to resistance offers one way to refuse liberal narratives of political action, but also reduces action to a negative and binary relation. How, in this light, might we imagine ‘post-liberal’ forms of political agency? How might we navigate and rework this set of problems? Taking political agency to be imagined and enacted locally, in situ and in practice, I draw on three years of praxiographic fieldwork with actors in higher education projects in the Canadian Arctic. In Canada, liberal logics and practices have justified and enacted colonization. The liberal settler state has reorganized and regulated politics, eroding Indigenous forms of government. Formal education has been central to this process and to liberal state-building in Canada. The thesis shows how, for those seeking to transform colonial realities, higher education is now a way of inhabiting, contesting, and reworking the meaning of political agency itself. Working closely with two university-building projects, I show that anti-colonial northern educators locate their agency not in one form of action or another, but in the dynamic interrelation of multiple forms. These actors are also concerned centrally with the ontology and spatio-temporality of particular logics of agency, and they theorize and enact these explicitly. I also show how, in response to these challenges, late liberal versions of political agency are emerging locally. As I tell this story, I examine my own implication in the research problem autoethnographically. I describe how my struggle to resist colonizing academic conventions from my own institutional setting co-evolved with the activities of participants. I describe how I followed their strategies in negotiating my own agency. I argue that in old and new universities and in the Canadian Arctic liberal narratives of political agency are latent in unexpected ways. They are also, however, often inhabited deliberately and creatively by local actors. These liberal logics of action are characterized by specific ontologies and spatio-temporalities, which they share with settler-colonialism. Settler-colonialism and liberalisms therefore intersect through these logics in higher education. I locate possibilities for post-liberal agency on this emerging and late liberal terrain. Post-liberal agency can, I conclude, be imagined in the interstices of this multiplicity of forms of agency, in the spatio-temporal and ontological practices of the everyday, and in the intersection of liberalisms and settler-colonialism in the university. My version of post-liberal agency is also, I propose, a way of decolonizing research as well as framing and practicing academic work and ethics more broadly

270V Battery Using COTS NiCd Cells For Manned Spacecraft

A high power (>35 kW at 215V), low capacity (5.2 Ah), and compact (45L) NiCd battery was developed for the X-38 Crew Return Vehicle (CRV), which is an experimental version of the lifeboat for the International Space Station (ISS). A simple design and innovative approach using a commercial-off-the-shelf (COTS) NiCd cell design enabled the design, qualification, and production of 4 flight units of this highly reliable and safe spacecraft battery to be achieved rapidly (2 years) and cheaply ($13M)

WAGES AGAINST INCLUSION! FULL INCLUSION NOW! Towards a queer manifesto against LGBT+ inclusion in universities

https://www.routledge.com/Queer-Sharing-in-the-Marketized-University/Mahn-Brim-Taylor/p/book/9781032066578pubpu

Development of a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. https://bmjopenrespres.bmj.com/content/bmjresp/5/1/e000265.full.pdfAlberta Innovates Health Solutions Partnership for Research and Innovation in the Health System Program (AIHS PRIHS 201400390), Alberta Health ServicesPeer ReviewedIntroduction: Hospital and emergency department discharge for patients with chronic obstructive pulmonary disease (COPD) is often poorly organised. We developed a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbations of COPD. Methods: A purposeful sample of clinicians and patients were invited to participate in a two-round Delphi study (July–November 2015). In round 1, participants rated on a seven-point Likert scale (1=not at all important; 7=extremely important) the importance of 29 unique COPD care actions. Round 2 comprised items selected from round 1 based on consensus (>80%endorsement for Likert values 5–7). A list of 18 care items from round 2 was discussed in a face-to-face nominal group meeting. Results: Seven care items were included in the COPD discharge bundle based on clinician and patient input: (1) ensure adequate inhaler technique is demonstrated; (2) send discharge summary to family physician and arrange follow-up; (3) optimise and reconcile prescription of respiratory medications; (4) provide a written discharge management plan and assess patient’s and caregiver’s comprehension of discharge instructions; (5) refer to pulmonary rehabilitation; (6) screen for frailty and comorbidities; and (7) assess smoking status, provide counselling and refer to smoking cessation programme. Conclusion: We present a seven-item, patient-centred, evidence-based and consensus-based discharge bundle for patients with acute exacerbations of COPD. Alignment with clinical practice guidelines and feasibility of local adaptations of the bundle should be explored to facilitate wide applicability and evaluation of the effectiveness of the COPD discharge bundle

Teaching politics after the practice turn

The ‘practice turn’ and its associated ontology, epistemology and methodology are now well established in political research. In this article, we identify and explore a corollary pedagogy. After outlining the principal components of practice theory, we compare case- and placement-based approaches to learning, designed to develop skills for use in practice. We introduce and describe our own rather different course, which we designed to develop an understanding of the nature of practice as such. We discuss its scope and dynamics, particularly with regard to power in the classroom, and identify broader opportunities and challenges for the development of practice-based pedagogy

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation

Oocyte donors have high serum estradiol (E2) levels similar to the serum levels seen in the first trimester of pregnancy. We report in this article our studies comparing cell proliferation, Ki67 (MIB1), and estrogen and progesterone receptor levels (ERα, PRA, and PRB) in the breast terminal duct lobular units of oocyte donors, women in early pregnancy, and in normally cycling women. Breast tissue and blood samples were obtained from 10 oocyte donors, and 30 pregnant women at 5–18 weeks of gestation. Breast tissue samples were also obtained from 26 normally cycling women. In the oocyte donors: peak E2 (mean ~15,300 pmol/l) was reached on the day before oocyte (and tissue) donation; peak progesterone (P4; mean 36.3 nmol/l) was reached on the day of donation; Ki67 was positively associated with level of E2, and the mean Ki67 was 7.0% significantly greater than the mean 1.8% of cycling women. In the pregnant women: mean E2 rose from ~2,000 pmol/l at 5 weeks of gestation to ~27,000 pmol/l at 18 weeks; mean P4 did not change from ~40 nmol/l until around gestational week 11 when it increased to ~80 nmol/l; mean Ki67 was 15.4% and did not vary with gestational age or E2. Oocyte donors have greatly increased levels of E2 and of breast-cell proliferation, both comparable in the majority of donors to the levels seen in the first trimester of pregnancy. Whether their short durations of greatly increased E2 levels are associated with any long-term beneficial effects on the breast, as occurring in rodent models, is not known

Concurrent Exposure of Bottlenose Dolphins (Tursiops truncatus) to Multiple Algal Toxins in Sarasota Bay, Florida, USA

Sentinel species such as bottlenose dolphins (Tursiops truncatus) can be impacted by large-scale mortality events due to exposure to marine algal toxins. In the Sarasota Bay region (Gulf of Mexico, Florida, USA), the bottlenose dolphin population is frequently exposed to harmful algal blooms (HABs) of Karenia brevis and the neurotoxic brevetoxins (PbTx; BTX) produced by this dinoflagellate. Live dolphins sampled during capture-release health assessments performed in this region tested positive for two HAB toxins; brevetoxin and domoic acid (DA). Over a ten-year study period (2000–2009) we have determined that bottlenose dolphins are exposed to brevetoxin and/or DA on a nearly annual basis (i.e., DA: 2004, 2005, 2006, 2008, 2009; brevetoxin: 2000, 2004, 2005, 2008, 2009) with 36% of all animals testing positive for brevetoxin (n = 118) and 53% positive for DA (n = 83) with several individuals (14%) testing positive for both neurotoxins in at least one tissue/fluid. To date there have been no previously published reports of DA in southwestern Florida marine mammals, however the May 2008 health assessment coincided with a Pseudo-nitzschia pseudodelicatissima bloom that was the likely source of DA observed in seawater and live dolphin samples. Concurrently, both DA and brevetoxin were observed in common prey fish. Although no Pseudo-nitzschia bloom was identified the following year, DA was identified in seawater, fish, sediment, snails, and dolphins. DA concentrations in feces were positively correlated with hematologic parameters including an increase in total white blood cell (p = 0.001) and eosinophil (p<0.001) counts. Our findings demonstrate that dolphins within Sarasota Bay are commonly exposed to two algal toxins, and provide the impetus to further explore the potential long-term impacts on bottlenose dolphin health

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC. METHODS: Within the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated. RESULTS: High-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss. CONCLUSION: This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC