Legal Regulation on Abuse of Dominant Market Position in China’s Internet Field

The legal regulation of abuse of market dominance in the Internet field needs to comprehensively consider the characteristics of subject specificity, subjective malice, illegal behavior, and harmful consequences. The abuse of market dominance in the Internet field differs from other industries in behavior, mainly including monopoly prices, predatory pricing, restricted transactions, tying or attaching unreasonable trading conditions, differential treatment, etc. This paper analyzes the main abuse of market dominance in the Internet field through cases, and studies its relevant legal regulations and preventive measures

Contribution of Stems and Leaves to the Quality of Keemun Black Tea

In order to understand the contribution of stems and leaves to the quality of Keemun black tea, this study analyzed the differences in aroma, taste quality and metabolites among black tea manufactured from tender leaves, tender stems, single buds and intact buds with leaves (mainly one bud with two leaves) from the tea variety ‘Fuzao 2’ by gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), sensory evaluation, and preference evaluation. The results showed that all four black teas were sweet aroma type, and the bud-leaf tea had a strong sweet aroma. The single-bud tea had a fresh and brisk taste. The tender-stem tea scored highest in preference evaluation. Metabolite analysis showed the content of catechins was the highest in the single-bud black tea and the lowest in the tender-stem black tea, while free amino acids were significantly enriched in the tender-stem black tea, reaching up to 80 mg/g. The contents of quercetin and rutin were higher in the stem black tea, while the contents of kaempferol-3-O-glucoside and kaempferol-3-O-rutinoside were the highest in the leaf black tea. The ratio of thearubigins to theaflavins was 11.6, 9.4, 14.6, and 8.2 in black tea made from intact buds with leaves, buds, leaves, and tender stems, respectively. The total amount of volatile compounds in the tender-stem black tea (32.37 μg/g) was significantly lower than that in the bud (100.01 μg/g), leaf (95.67 μg/g), and bud-leaf black tea (92.42 μg/g). The contents of benzaldehyde, benzeneacetaldehyde and indole were higher in the tender stem black tea, while the contents of β-ionone, α-ionone and linalool oxide in the leaf black tea were higher than those in the other three black teas. This study shows that high contents of theanine in tender stems and glycoside aroma precursors in tea leaves contribute primarily to the formation of the quality of Keemun black tea

Diameter effect on the heat transfer of supercritical hydrocarbon fuel in horizontal tubes under turbulent conditions

This document is the Accepted Manuscript version of the following article: Zeyuan Cheng, Zhi Tao, Jianqin Zhu, and Hongwei Wu, ‘Diameter effect on the heat transfer of supercritical hydrocarbon fuel in horizontal tubes under turbulent conditions’, Applied Thermal Engineering, Vol. 134: 39-53, April 2018. Under embargo until 31 January 2019. The final, definitive version is available online at: https://doi.org/10.1016/j.applthermaleng.2018.01.105This article presented a numerical investigation of supercritical heat transfer of the hydrocarbon fuel in a series of horizontal tubes with different diameters. The Reynolds averaging equations of mass, momentum and energy with the LS low-Reynolds number turbulence model have been solved using the pressure-based segregated solver based on the finite volume method. For the purpose of comparison, a four-species surrogate model and a ten-species surrogate model of the aviation kerosene RP-3 (Rocket Propellant 3) were tested against the published experimental data. In the current study, the tube diameter varied from 2 mm to 10 mm and the pressure was 3 MPa with heat flux to mass flux ratios ranging from 0.25 to 0.71 kJ/kg. It was found that the buoyancy has significant effect on the wall temperature non-uniformity in the horizontal tube. With the increase of the diameter, the buoyancy effect enhances and the thermal-induced acceleration effect reduces. The buoyancy effect makes wall temperature at the top and bottom generatrices of the horizontal tube increase and decrease, respectively. Due to the coupled effect of the buoyancy and thermal-induced acceleration caused by the significant change of the properties, as the diameter increases, the heat transfer deteriorates dramatically at the top generatrix but remains almost unchanged at the bottom generatrix at high heat flux to mass flux ratio. Heat transfer enhancement is observed at low heat flux to mass flux ratio when the tube diameter is less than 6 mm. Moreover, the safety analysis has been performed in order to optimally design the supercritical cooling system.Peer reviewe

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke

Importance It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. Objective To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO. Design, Setting, and Participants This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 patients with stroke and proximal intracranial LVO presenting within 24 hours of time last known to be well. Recruitment took place between February 9, 2022, and June 30, 2023, with a final follow-up on September 30, 2023.InterventionsEligible patients were randomly assigned to intravenous methylprednisolone (n = 839) at 2 mg/kg/d or placebo (n = 841) for 3 days adjunctive to endovascular thrombectomy. Main Outcomes and Measures The primary efficacy outcome was disability level at 90 days as measured by the overall distribution of the modified Rankin Scale scores (range, 0 [no symptoms] to 6 [death]). The primary safety outcomes included mortality at 90 days and the incidence of symptomatic intracranial hemorrhage within 48 hours. Results Among 1680 patients randomized (median age, 69 years; 727 female [43.3%]), 1673 (99.6%) completed the trial. The median 90-day modified Rankin Scale score was 3 (IQR, 1-5) in the methylprednisolone group vs 3 (IQR, 1-6) in the placebo group (adjusted generalized odds ratio for a lower level of disability, 1.10 [95% CI, 0.96-1.25]; P = .17). In the methylprednisolone group, there was a lower mortality rate (23.2% vs 28.5%; adjusted risk ratio, 0.84 [95% CI, 0.71-0.98]; P = .03) and a lower rate of symptomatic intracranial hemorrhage (8.6% vs 11.7%; adjusted risk ratio, 0.74 [95% CI, 0.55-0.99]; P = .04) compared with placebo. Conclusions and Relevance Among patients with acute ischemic stroke due to LVO undergoing endovascular thrombectomy, adjunctive methylprednisolone added to endovascular thrombectomy did not significantly improve the degree of overall disability.Trial RegistrationChiCTR.org.cn Identifier: ChiCTR210005172

Hydrologic Simulation of a Winter Wheat–Summer Maize Cropping System in an Irrigation District of the Lower Yellow River Basin, China

Conflicts between water supply and water demand are intensifying in irrigation districts along the Lower Yellow River due to climate change and human activities. To ensure both adequate food supply and water resource sustainability in China, the Soil and Water Assessment Tool (SWAT) model was used to simulate the water balance and water use of agro-ecosystems in an irrigation district of the lower Yellow River Basin, China. Simulated average annual irrigation requirements decreased from 1969 to 2010. Irrigation requirements during the winter wheat season decreased owing to reduced reference evapotranspiration and increased precipitation. Annual evapotranspiration (ET) increased with increasing irrigation volume, and differences among irrigation scenarios were mainly due to ET of winter wheat. Water deficit typically occurred during winter wheat seasons with less precipitation. Field seepage and surface runoff tended to occur in years with high precipitation, particularly during the summer maize season under full irrigation and scheduled irrigation scenarios. Frequent and heavy irrigation did not always lead to high water use efficiency. To cope with limited water resources in this region, it is necessary to properly irrigate crops based on soil water content and take full advantage of precipitation and surface runoff during the summer maize season

Aqueous humor monocyte chemoattractant protein-1 predicted long-term visual outcome of proliferative diabetic retinopathy undergone intravitreal injection of bevacizumab and vitrectomy.

PurposeWe aim to investigate the risk factors associated with the prognosis of proliferative diabetic retinopathy (PDR) after a sequential treatment of intravitreal injection of bevacizumab (IVB) and pars plana vitrectomy (PPV).MethodsIn this cohort study, 63 eyes from 55 patients (21 females) diagnosed with PDR, who needed PPV for non-clearing vitreous hemorrhage or fibrovascular membrane proliferation were enrolled. All the eyes underwent IVB followed by PPV. Anterior chamber tap was performed at the beginning of both procedures to evaluate the concentration of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-8, and monocyte chemoattractant protein (MCP)-1.ResultsForty-seven patients (54 eyes) were followed over six months, averaging 12±5 (6-19) months. The concentration of VEGF significantly decreased after IVB (PConclusionsMCP-1 was a predictor for the unfavorable visual outcome of PDR after IVB pretreatment and PPV

Analysis of Hydrologic Drought Frequency Using Multivariate Copulas in Shaying River Basin

Droughts, considered one of the most dangerous and costly water cycle expressions, always occurs over a certain region, lasting several weeks or months, and involving multiple variables. In this work, a multivariate approach was used for the statistical characterization of hydrological droughts in Shaying River Basin with data from 1959–2008. The standard runoff index (SRI) and the run theory were employed to defined hydrological drought character variables (duration, severity, and intensity peak). Then, a multivariate joint probability analysis with four symmetric and corresponding asymmetric Archimedean Copulas was presented; and the multivariate frequency analysis with the joint return periods (Tand and Tor) were estimated. The results showed that the hydrological droughts have a severity of 4.79 and 5.09, and the drought intensity peak is of 1.35 and 1.50 in Zhoukou station and Luohe station, respectively; the rank correlation coefficients τ are more than 0.5, which means multivariate copulas can effectively describe the joint frequency distributions among multivariate variables. Drought risk shows a spatial variation: the downstream observed at Zhoukou station is characterized by a higher multivariate drought risk. In general, multivariate copulas provide a reliable method when constructing a comprehensive drought index and evaluating multivariate drought characteristics. Thus, this paper can provide useful indications for the multi-dimensional droughts’ risks assessment in Shaying River Basin