19,577 research outputs found
Unstable particle's wave-function renormalization prescription
We strictly define two set Wave-function Renormalization Constants (WRC)
under the LSZ reduction formula for unstable particles at the first time. Then
by introducing antiparticle's WRC and the CPT conservation law we obtain a new
wave-function renormalization condition which can be used to totally determine
the two set WRC. We calculate two physical processes to manifest the
consistence of the present wave-function renormalization prescription with the
gauge theory in standard model. We also prove that the conventional
wave-function renormalization prescription which discards the imaginary part of
unstable particle's WRC leads to physical amplitude gauge dependent.Comment: 10 pages, 3 figure
Preparation, Structure, and Reactivity of Nonstabilized Organoiron Compounds. Implications for Iron-Catalyzed Cross Coupling Reactions
A series of unprecedented organoiron complexes of the formal oxidation states −2, 0, +1, +2, and +3 is presented, which are largely devoid of stabilizing ligands and, in part, also electronically unsaturated (14-, 16-, 17- and 18-electron counts). Specifically, it is shown that nucleophiles unable to undergo β-hydride elimination, such as MeLi, PhLi, or PhMgBr, rapidly reduce Fe(3+) to Fe(2+) and then exhaustively alkylate the metal center. The resulting homoleptic organoferrate complexes [(Me4Fe)(MeLi)][Li(OEt2)]2 (3) and [Ph4Fe][Li(Et2O)2][Li(1,4-dioxane)] (5) could be characterized by X-ray crystal structure analysis. However, these exceptionally sensitive compounds turned out to be only moderately nucleophilic, transferring their organic ligands to activated electrophiles only, while being unable to alkylate (hetero)aryl halides unless they are very electron deficient. In striking contrast, Grignard reagents bearing alkyl residues amenable to β-hydride elimination reduce FeXn (n = 2, 3) to clusters of the formal composition [Fe(MgX)2]n. The behavior of these intermetallic species can be emulated by structurally well-defined lithium ferrate complexes of the type [Fe(C2H4)4][Li(tmeda)]2 (8), [Fe(cod)2][Li(dme)]2 (9), [CpFe(C2H4)2][Li(tmeda)] (7), [CpFe(cod)][Li(dme)] (11), or [Cp*Fe(C2H4)2][Li(tmeda)] (14). Such electron-rich complexes, which are distinguished by short intermetallic Fe−Li bonds, were shown to react with aryl chlorides and allyl halides; the structures and reactivity patterns of the resulting organoiron compounds provide first insights into the elementary steps of low valent iron-catalyzed cross coupling reactions of aryl, alkyl, allyl, benzyl, and propargyl halides with organomagnesium reagents. However, the acquired data suggest that such C−C bond formations can occur, a priori, along different catalytic cycles shuttling between metal centers of the formal oxidation states Fe(+1)/Fe(+3), Fe(0)/Fe(+2), and Fe(−2)/Fe(0). Since these different manifolds are likely interconnected, an unambiguous decision as to which redox cycle dominates in solution remains difficult, even though iron complexes of the lowest accessible formal oxidation states promote the reactions most effectively
A role for chromatin remodellers in replication of damaged DNA
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure. There are two isoforms of the Remodels the Structure of Chromatin (RSC) remodelling complex in yeast. We show that deletion of RSC2 results in a dramatic reduction in the level of PCNA ubiquitination after DNA-damaging treatments, whereas no such effect was observed after deletion of RSC1. Similarly, depletion of the BAF180 component of the corresponding PBAF (Polybromo BRG1 (Brahma-Related Gene 1) Associated Factor) complex in human cells led to a similar reduction in PCNA ubiquitination. Remarkably, we found that depletion of BAF180 resulted after UV-irradiation, in a reduction not only of ubiquitinated PCNA but also of chromatin-associated unmodified PCNA and Rad18 (the E3 ligase that ubiquitinates PCNA). This was accompanied by a modest decrease in fork progression. We propose a model to account for these findings that postulates an involvement of PBAF in repriming of replication downstream from replication forks blocked at sites of DNA damage. In support of this model, chromatin immunoprecipitation data show that the RSC complex in yeast is present in the vicinity of the replication forks, and by extrapolation, this is also likely to be the case for the PBAF complex in human cells
Fibrational induction meets effects
This paper provides several induction rules that can be used to prove properties of effectful data types. Our results are semantic in nature and build upon Hermida and Jacobs’ fibrational formulation of induction for polynomial data types and its extension to all inductive data types by Ghani, Johann, and Fumex. An effectful data type μ(TF) is built from a functor F that describes data, and a monad T that computes effects. Our main contribution is to derive induction rules that are generic over all functors F and monads T such that μ(TF) exists. Along the way, we also derive a principle of definition by structural recursion for effectful data types that is similarly generic. Our induction rule is also generic over the kinds of properties to be proved: like the work on which we build, we work in a general fibrational setting and so can accommodate very general notions of properties, rather than just those of particular syntactic forms. We give examples exploiting the generality of our results, and show how our results specialize to those in the literature, particularly those of Filinski and Støvring
Single Parameter Combinatorial Auctions with Partially Public Valuations
We consider the problem of designing truthful auctions, when the bidders'
valuations have a public and a private component. In particular, we consider
combinatorial auctions where the valuation of an agent for a set of
items can be expressed as , where is a private single parameter
of the agent, and the function is publicly known. Our motivation behind
studying this problem is two-fold: (a) Such valuation functions arise naturally
in the case of ad-slots in broadcast media such as Television and Radio. For an
ad shown in a set of ad-slots, is, say, the number of {\em unique}
viewers reached by the ad, and is the valuation per-unique-viewer. (b)
From a theoretical point of view, this factorization of the valuation function
simplifies the bidding language, and renders the combinatorial auction more
amenable to better approximation factors. We present a general technique, based
on maximal-in-range mechanisms, that converts any -approximation
non-truthful algorithm () for this problem into
and -approximate truthful
mechanisms which run in polynomial time and quasi-polynomial time,
respectively
Study of non-equilibrium effects and thermal properties of heavy ion collisions using a covariant approach
Non-equilibrium effects are studied using a full Lorentz-invariant formalism.
Our analysis shows that in reactions considered here, no global or local
equilibrium is reached. The heavier masses are found to be equilibrated more
than the lighter systems. The local temperature is extracted using hot Thomas
Fermi formalism generalized for the case of two interpenetrating pieces of
nuclear matter. The temperature is found to vary linearly with bombarding
energy and impact parameter whereas it is nearly independent of the mass of the
colliding nuclei. This indicates that the study of temperature with medium size
nuclei is also reliable. The maximum temperatures obtained in our approach are
in a nice agreement with earlier calculations of other approaches. A simple
parametrization of maximal temperature as a function of the bombarding energy
is also given.Comment: LaTex-file, 17 pages, 8 figures (available upon request), Journal of
Physics G20 (1994) 181
Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage
The rad2 mutant of Schizosaccharomyces pombe is sensitive to UV irradiation and deficient in the repair of UV damage. In addition, it has a very high degree of chromosome loss and/or nondisjunction. We have cloned the rad2 gene and have shown it to be a member of the Saccharomyces cerevisiae RAD2/S. pombe rad13/human XPG family. Using degenerate PCR, we have cloned the human homolog of the rad2 gene. Human cDNA has 55% amino acid sequence identity to the rad2 gene and is able to complement the UV sensitivity of the rad2 null mutant. We have thus isolated a novel human gene which is likely to be involved both in controlling the fidelity of chromosome segregation and in the repair of UV-induced DNA damage. Its involvement in two fundamental processes for maintaining chromosomal integrity suggests that it is likely to be an important component of cancer avoidance mechanisms
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage
The Schizosaccharomyces pombe SMC proteins Rad18 (Smc6) and Spr18 (Smc5) exist in a high-M(r) complex which also contains the non-SMC proteins Nse1, Nse2, Nse3, and Rad62. The Smc5-6 complex, which is essential for viability, is required for several aspects of DNA metabolism, including recombinational repair and maintenance of the DNA damage checkpoint. We have characterized Nse2 and show here that it is a SUMO ligase. Smc6 (Rad18) and Nse3, but not Smc5 (Spr18) or Nse1, are sumoylated in vitro in an Nse2-dependent manner, and Nse2 is itself autosumoylated, predominantly on the C-terminal part of the protein. Mutations of C195 and H197 in the Nse2 RING-finger-like motif abolish Nse2-dependent sumoylation. nse2.SA mutant cells, in which nse2.C195S-H197A is integrated as the sole copy of nse2, are viable, whereas the deletion of nse2 is lethal. Smc6 (Rad18) is sumoylated in vivo: the sumoylation level is increased upon exposure to DNA damage and is drastically reduced in the nse2.SA strain. Since nse2.SA cells are sensitive to DNA-damaging agents and to exposure to hydroxyurea, this implicates the Nse2-dependent sumoylation activity in DNA damage responses but not in the essential function of the Smc5-6 complex
Live and Dead Nodes
In this paper, we explore the consequences of a distinction between `live'
and `dead' network nodes; `live' nodes are able to acquire new links whereas
`dead' nodes are static. We develop an analytically soluble growing network
model incorporating this distinction and show that it can provide a
quantitative description of the empirical network composed of citations and
references (in- and out-links) between papers (nodes) in the SPIRES database of
scientific papers in high energy physics. We also demonstrate that the death
mechanism alone can result in power law degree distributions for the resulting
network.Comment: 12 pages, 3 figures. To be published in Computational and
Mathematical Organization Theor
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