Alcohol intake and early‐onset basal cell carcinoma in a case–control study

BackgroundPrevious epidemiological studies of overall alcohol intake and basal cell carcinoma (BCC) are inconsistent, with some evidence for differences by type of alcoholic beverage. While alcohol may enhance the carcinogenicity of ultraviolet (UV) radiation, this has not been evaluated in existing epidemiological studies.ObjectivesTo evaluate alcohol intake in relation to early-onset BCC, and explore potential interactions with UV exposure.MethodsBasal cell carcinoma cases (n = 380) and controls with benign skin conditions (n = 390) under 40 years of age were identified through Yale Dermatopathology. Participants provided information on lifetime alcohol intake, including type of beverage, during an in-person interview. Self-reported data on indoor tanning and outdoor sunbathing were used to categorize UV exposure. We calculated odds ratios (OR) and 95% confidence intervals (CIs) using unconditional multivariate logistic regression in the full sample and in women only.ResultsThere was no statistically significant association between lifetime alcohol intake and early-onset BCC overall [above median intake vs. no regular alcohol intake (OR 1·10, 95% CI 0·69-1·73)] or in women only (OR 1·21, 95% CI 0·73-2·01). Similarly, intake of red wine, white wine, beer or spirits and mixed drinks was not associated with early-onset BCC. In exploratory analyses, we saw limited evidence for an interaction (P(interaction) = 0·003), with highest risk for high alcohol and high UV exposures, especially in women, but subgroup risk estimates had wide and overlapping CIs.ConclusionsOverall, we did not observe any clear association between lifetime alcohol intake and early-onset BCC

Uso de esponja cirúrgica para curativo compressivo de enxerto cutâneo Surgical sponge as a pressure dressing for skin grafts

O enxerto cutâneo é um modo efetivo para restaurar feridas. O curativo compressivo é importante para a vitalidade do enxerto. Os autores observaram que o uso de esponja cirúrgica como curativo compressivo em enxertos cutâneos é factível e aconselhável.<br>Cutaneous graft is an effective way to treat wounds. A pressure dressing is important for the vitality of such grafts. We have observed that the use of surgical sponge as a pressure dressing on cutaneous grafts is feasible and recommend its use

Basal cell carcinoma of the eyelid in children: a report of three cases

Basal cell carcinoma is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid tumours. Despite its prevalence in adults, it is extremely rare in children, and usually occurs in the setting of a known genetic defect or following radiotherapy treatment. We report three cases of de novo basal cell carcinoma in children. These children had no known genetic syndromes and had not undergone radiotherapy.McGill Univ, Montreal Gen Hosp, Dept Ophthalmol, Henry S Witelson Ocular Pathol Lab, Montreal, PQ H3G 1A4, CanadaRoyal Victoria Hosp, Montreal, PQ H3A 1A1, CanadaUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Scienc