1,257 research outputs found
Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia.
BACKGROUND: In first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes. AIMS: To address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point. METHOD: Symptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later. RESULTS: There was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition. CONCLUSIONS: Longer DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP
Circuit Theory
Contains reports on two research projects.Lincoln Laboratory, Purchase Order DDL-B222U.S. Air Force under Air Force Contract AF19(604)-520
Circuit Theory
Contains reports on three research projects.Lincoln Laboratory (Purchase Order DDL-B222)United States Department of the ArmyUnited States Department of the NavyUnited States Department of the Air Force (Contract AF19(604)-5200
p-Adic Models of Ultrametric Diffusion Constrained by Hierarchical Energy Landscapes
We demonstrate that p-adic analysis is a natural basis for the construction
of a wide variety of the ultrametric diffusion models constrained by
hierarchical energy landscapes. A general analytical description in terms of
p-adic analysis is given for a class of models. Two exactly solvable examples,
i.e. the ultrametric diffusion constraned by the linear energy landscape and
the ultrametric diffusion with reaction sink, are considered. We show that such
models can be applied to both the relaxation in complex systems and the rate
processes coupled to rearrangenment of the complex surrounding.Comment: 14 pages, 6 eps figures, LaTeX 2.0
Stability of Resonant Opto-Mechanical Oscillators
We theoretically study the frequency stability of an opto-mechanical radio
frequency oscillator based on resonant interaction of two optical and one
mechanical modes of the same optical microcavity. A generalized expression for
the phase noise of the oscillator is derived using Langevin formalism and
compared to the phase noise of existing electronic oscillators.Comment: 6 pages, 1 figur
Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing
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