88 research outputs found
A rarefaction-tracking method for hyperbolic conservation laws
We present a numerical method for scalar conservation laws in one space
dimension. The solution is approximated by local similarity solutions. While
many commonly used approaches are based on shocks, the presented method uses
rarefaction and compression waves. The solution is represented by particles
that carry function values and move according to the method of characteristics.
Between two neighboring particles, an interpolation is defined by an analytical
similarity solution of the conservation law. An interaction of particles
represents a collision of characteristics. The resulting shock is resolved by
merging particles so that the total area under the function is conserved. The
method is variation diminishing, nevertheless, it has no numerical dissipation
away from shocks. Although shocks are not explicitly tracked, they can be
located accurately. We present numerical examples, and outline specific
applications and extensions of the approach.Comment: 21 pages, 7 figures. Similarity 2008 conference proceeding
Anchoring of proteins to lactic acid bacteria
The anchoring of proteins to the cell surface of lactic acid bacteria (LAB) using genetic techniques is an exciting and emerging research area that holds great promise for a wide variety of biotechnological applications. This paper reviews five different types of anchoring domains that have been explored for their efficiency in attaching hybrid proteins to the cell membrane or cell wall of LAB. The most exploited anchoring regions are those with the LPXTG box that bind the proteins in a covalent way to the cell wall. In recent years, two new modes of cell wall protein anchoring have been studied and these may provide new approaches in surface display. The important progress that is being made with cell surface display of chimaeric proteins in the areas of vaccine development and enzyme- or whole-cell immobilisation is highlighted.
The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim
Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study
Peer reviewe
Evaluation of novel inducible promoter/repressor systems for recombinant protein expression in Lactobacillus plantarum
GENE DISRUPTION IN LACTOBACILLUS-PLANTARUM STRAIN-80 BY SITE-SPECIFIC RECOMBINATION - ISOLATION OF A MUTANT STRAIN DEFICIENT IN CONJUGATED BILE-SALT HYDROLASE ACTIVITY.
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