IL-10 Blocks the Development of Resistance to Re-Infection with Schistosoma mansoni

Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance to reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, and often develops in only a small cohort of individuals. Using a well-established and highly permissive mouse model, we investigated whether immunoregulatory mechanisms influence the development of resistance. Following Praziquantel (PZQ) treatment of S. mansoni infected mice we observed a significant and mixed anti-worm response, characterized by Th1, Th2 and Th17 responses. Despite the elevated anti-worm response in PBMC's, liver, spleen and mesenteric lymph nodes, this did not confer any protection from a secondary challenge infection. Because a significant increase in IL-10-producing CD4+CD44+CD25+GITR+ lymphocytes was observed, we hypothesised that IL-10 was obstructing the development of resistance. Blockade of IL-10 combined with PZQ treatment afforded a greater than 50% reduction in parasite establishment during reinfection, compared to PZQ treatment alone, indicating that IL-10 obstructs the development of acquired resistance. Markedly enhanced Th1, Th2 and Th17 responses, worm-specific IgG1, IgG2b and IgE and circulating eosinophils characterized the protection. This study demonstrates that blocking IL-10 signalling during PZQ treatment can facilitate the development of protective immunity and provide a highly effective strategy to protect against reinfection with S. mansoni

AmI in good care? Developing design principles for ambient intelligent domotics for elderly

The combination of ambient intelligence (AmI) and domotics has the potential to respond to elderly people's desire to live independent from extensive forms of care. Their slow adoption of technological aids shows reluctance, though. This article investigates their motivations to adopt ambient intelligent domotics, and proposes design principles specifically based on their preferences and experiences. Respondents appeared to be more acceptive of tangible problems they expected with AmI domotics than intangible ones. In addition, their opinions seemed to be profoundly influenced by the way they perceived their psychological quality of life, while their physical conditions did not seem to have noticeable impacts

A famine in Surat in 1631 and Dodos on Mauritius: a long lost manuscript rediscovered

In 1887 Dutch archivist A. J. Servaas van Rooijen published a transcript of a hand-written copy of an anonymous missive or letter, dated 1631, about a horrific famine and epidemic in Surat, India, and also an important description of the fauna of Mauritius. The missive may have been written by a lawyer acting on behalf of the Dutch East India Company (VOC). It not only gives details about the famine, but also provides a unique insight into the status of endemic and introduced Mauritius species, at a time when the island was mostly uninhabited and used only as a replenishment station by visiting ships. Reports from this period are very rare. Unfortunately, Servaas van Rooijen failed to mention the location of the missive, so its whereabouts remained unknown; as a result, it has only been available as a secondary source. Our recent rediscovery of the original hand-written copy provides details about the events that took place in Surat and Mauritius in 1631–1632. A full English translation of the missive is appended