Shame as a social phenomenon

Purpose: This paper argues for a theoretical approach to chronic shame which emphasises social factors in the development of psychological problems. Some of the implications of this for research and clinical practice are considered. Context: Clinical psychologists are increasingly drawing on the concept of shame to inform therapeutic work. However, a comprehensive review of clinically-orientated research on shame over a four-year period revealed that this has mostly been restricted to the investigation of individual differences, conceptualising shame as an attribute of the individual. Key Points: It is argued that the notion of shame as a context-free intrapsychic variable has distracted clinical researchers from investigating shame as a lived emotional experience and has made the social constitution of shame less visible. As such, there is very little data available on the avoidance, management and repair of experiences of shame and little exploration of how shameful identities might emerge in particular social contexts. Several suggestions are made for alternative ways in which susceptibility to shame could be conceptualised, which consider the individual’s social world and the importance of the roles or subject positions available. Conclusions: To better inform clinical practice, research needs to focus more explicitly on the social and interpersonal processes which either enable or inhibit the avoidance, management and repair of shame. The implications of a more contextualised understanding of shame for practitioners include a willingness to (a) work with clients at achieving real changes in their social worlds and (b) to develop services which offer positive identities for user

Computing left Kan extensions

AbstractWe describe a new extension of the Todd–Coxeter algorithm adapted to computing left Kan extensions. The algorithm is a much simplified version of that introduced by Carmody and Walters (Category Theory, Proceedings of the International Conference Held in Como, Italy, 22–28 July 1990. Springer) in 1991. The simplification allows us to give a straightforward proof of its correctness and termination when the extension is finite

The Ursinus Weekly, October 31, 1949

Fifty sophs accept bids during fall rush season • Varied events to fill alumni homecoming • Helfferichs choose Dolman to manage \u27Pygmalion\u27 staging • Luxford to present women\u27s viewpoint in forum address • Fireside chats fill Y weekly schedule Wednesday evening • TKA nominates six at secret gathering • Hayride and masquerade highlight soph week-end • Organizations receive cut in budget appropriations • Chess club downs Lansdale in first match of season • Library display reveals Ursinus customs, history • Editorial: School spirit • Booters beat alumni; yield to Swarthmore • Bears to face F&M on old timers\u27 day • Bruins succumb 34-6 to alert Wagner club • Hockey team bows in first home tilt • Cross country squad loses initial dual meet to Garnet • WAA plans Friday night dance, hockey game for belles, bootershttps://digitalcommons.ursinus.edu/weekly/1575/thumbnail.jp

The Ursinus Weekly, February 20, 1950

Yearbook to stage Horror, inc. night in week campaign • Fraternities welcome 67 as rushing season ends • Organization join to send assistance for schools abroad • Y chats to discuss U.S. foreign policy; Religion week near • Seniors head cast for Dream waltz , Straus\u27 music show • WAA femmes plan night of minstrelsy, comedy and music • Dean\u27s men capture bitter 110-97 victory over busy b-listers • Thespians to enter Junior miss trials for May production • Dr. White narrates Color Day history; reviews progress of Ursinus women • Women to sponsor Senator Wood here • Miller takes leave for speaking tour • March 14 to close \u2750 pageant contest • Varsity Club men initiate new attendance regulation • Boswell, Chandler to take sides in debate on economic situation • Economics to see twenty-year slump, thanks to Roberts • Tony adds ltalian zest to Ursinus dining fare • Forum speaker urges return to verse, reconciliation of all people with poets • Derrites formulate unique mental law as result of finals • \u2751ers\u27 harmony to vie with college foursomes • Bruins yield 65-49 to league leaders; Forsyth gets honor • Belles down Albright for first win 38-31 • Second loss comes to badminton team • Courtmen divide tilts over busy week-end • Bruin grapplers continue long undefeated record • Jayvees drop two after Delaware win • Garnet gets 38-19 victory over Ursinus tank team • Lassies lose 37-26; rally gives margin to Immaculata gals • Meistersingers group sings in Lebanon and Springfield • March of Dimes receives poor campus total of $27https://digitalcommons.ursinus.edu/weekly/1584/thumbnail.jp

Harmonic Superspaces in Low Dimensions

Harmonic superspaces for spacetimes of dimension $d\leq 3$ are constructed. Some applications are given.Comment: 16, kcl-th-94-15. Two further references have been added (12 and 13) and a few typographical errors have been correcte

Digital twin of an urban-integrated hydroponic farm

AbstractThis paper presents the development process of a digital twin of a unique hydroponic underground farm in London, Growing Underground (GU). Growing 12x more per unit area than traditional greenhouse farming in the UK, the farm also consumes 4x more energy per unit area. Key to the ongoing operational success of this farm and similar enterprises is finding ways to minimize the energy use while maximizing crop growth by maintaining optimal growing conditions. As such, it belongs to the class of Controlled Environment Agriculture, where indoor environments are carefully controlled to maximize crop growth by using artificial lighting and smart heating, ventilation, and air conditioning systems. We tracked changing environmental conditions and crop growth across 89 different variables, through a wireless sensor network and unstructured manual records, and combined all the data into a database. We show how the digital twin can provide enhanced outputs for a bespoke site like GU, by creating inferred data fields, and show the limitations of data collection in a commercial environment. For example, we find that lighting is the dominant environmental factor for temperature and thus crop growth in this farm, and that the effects of external temperature and ventilation are confounded. We combine information learned from historical data interpretation to create a bespoke temperature forecasting model (root mean squared error &lt; 1.3°C), using a dynamic linear model with a data-centric lighting component. Finally, we present how the forecasting model can be integrated into the digital twin to provide feedback to the farmers for decision-making assistance.</jats:p

Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients

During cancer progression, the homeostasis of the extracellular matrix becomes imbalanced with an excessive collagen remodeling by matrix metalloproteinases. As a consequence, small protein fragments of degraded collagens are released into the circulation. We have investigated the potential of protein fragments of collagen type I, III and IV as novel biomarkers for colorectal cancer. Specific fragments of degraded type I, III and IV collagen (C1M, C3M, C4M) and type III collagen formation (Pro-C3) were assessed in serum from colorectal cancer patients, subjects with adenomas and matched healthy controls using well-characterized and validated ELISAs. Serum levels of the biomarkers were significantly elevated in colorectal cancer patients compared to subjects with adenomas (C1M, Pro-C3, C3M) and controls (C1M, Pro-C3). When patients were stratified according to their tumour stage, all four biomarkers were able to differentiate stage IV metastatic patients from all other stages. Combination of all markers with age and gender in a logistic regression model discriminated between metastatic and non-metastatic patients with an AUROC of 0.80. The data suggest that the levels of these collagen remodeling biomarkers may be a measure of tumour activity and invasiveness and may provide new clinical tools for monitoring of patients with advanced stage colorectal cancer

Serum type xix collagen is significantly elevated in non-small cell lung cancer:A preliminary study on biomarker potential

Type XIX collagen is a poorly characterized collagen associated with the basement membrane. It is abnormally regulated during breast cancer progression and the NC1 (XIX) domain has anti-tumorigenic signaling properties. However, little is known about the biomarker potential of collagen XIX in cancer. In this study, we describe a competitive ELISA, named PRO-C19, targeting the C-terminus of collagen XIX using a monoclonal antibody. PRO-C19 was measured in serum of patients with a range of cancer types and was elevated in non-small cell lung cancer (NSCLC) (p &lt; 0.0001), small cell lung cancer (p = 0.0081), breast (p = 0.0005) and ovarian cancer (p &lt; 0.0001) compared to healthy controls. In a separate NSCLC cohort, PRO-C19 was elevated compared to controls when evaluating adenocarcinoma (AD) (p = 0.0003) and squamous cell carcinoma (SCC) (p &lt; 0.0001) patients but was not elevated in chronic obstructive pulmonary disease patients. SCC also had higher PRO-C19 levels than AD (p = 0.0457). PRO-C19 could discriminate between NSCLC and healthy controls (AUROC:0.749 and 0.826 for AD and SCC, respectively) and maintained discriminatory performance in patients of tumor stages I+II (AUROC:0.733 and 0.818 for AD and SCC, respectively). Lastly, we confirmed the elevated type XIX collagen levels using gene expression data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) initiatives. In conclusion, type XIX collagen is released into circulation and is significantly elevated in the serum of cancer patients and PRO-C19 shows promise as a cancer biomarker

The Ursinus Weekly, January 16, 1950

Poet Davison to appear at third Ursinus forum • Thirty-one make up semester grad list, largest at Ursinus • Coeds plan field day with Lorelei at hand • Y students journey for week-end work in negro slum area • Dr. High discusses facts of allergies for pre-med group • Campus agent plans Chesterfield series • Gals! Write pageant for fame, fortune, and fifteen dollars • WSGA names group to revise customs • Photographer films So much to be done • Student leaders complete schedule for second term • Myk enjoys life here; Admires labs, libraries • Frosh face finals • Bruin matmen garner eighth in win record • Grid lettermen pick Don Young to lead squad next season • Courtmen suffer defeat after edging Textile five • League games start in interdorm circuit • Coed athletes await opening of rosters with second termhttps://digitalcommons.ursinus.edu/weekly/1582/thumbnail.jp