Overcoming the Legacy of Mistrust: African Americans’ Mistrust of Medical Profession

Recent studies show that racism still exists in the American medical profession, the fact of which legitimizes the historically long-legacy of mistrust towards medical profession and health authorities among African Americans. Thus, it was suspected that the participation of black patients in end-of-life care has always been significantly low stemmed primarily from their mistrust of the medical profession. On the other hand, much research finds that there are other reasons than the mistrust which makes African Americans feel reluctant to the end-of-life care, such as cultural-religious difference and genuine misunderstanding of the services. If so, two crucial questions are raised. One is how pervasive or significant the mistrust is, compared to the other factors, when they opt out of the end-of-life care. The other is if there is a remedy or solution to the seemingly broken relationship. While no studies available answer these questions, we have conducted an experiment to explore them. The research was performed at two Philadelphia hospitals of Mercy Health System, and the result shows that Black patients’ mistrust is not too great to overcome and that education can remove the epistemic obstacles as well as overcome the mistrust

“If I Don’t Take Care of Myself, I Can’t Take Care of Them:” Exploring Caregiving Grandmothers’ Experiences of a 9-Session Self-Care Curriculum

Abstract The predominance of research on custodial grandparent caregiving focuses on prevalence, risk factors, and challenges; less attention has been paid to the development of interventions to support this population. In response to a decrease in length of service provision at a local agency, a 9-session self-care curriculum was designed to focus on caregiver health through the empowering, multi-dimensional practice of self-care. The curriculum uses a mind-body approach and was integrated into a pre-existing 9-month support program for grandparents raising grandchildren. Using a basic, interpretive qualitative design, the purpose of this study was to explore how grandparent caregivers: 1) understand and practice self-care in their lives and 2) experienced self-care curriculum introduced within a pre-existing support group. Data were collected though qualitative interviews and analyzed concurrently using basic thematic analysis; techniques used included open and focused coding, cross-checking, and memoing. Study findings reveal self-care was most often understood in terms of physical health, caregiving brought meaning and purpose, and preferred self-care activities focused on introspection, solitude, and spirituality. Participants reported the curriculum was helpful, citing benefits such as present-moment awareness, relaxation, and connection. Implications for practice and future research are included

The Spectral Energy Distribution and Infrared Luminosities of z ≈ 2 Dust-obscured Galaxies from Herschel and Spitzer

Dust-obscured galaxies (DOGs) are a subset of high-redshift (z ≈ 2) optically-faint ultra-luminous infrared galaxies (ULIRGs, e.g., L_(IR) > 10^(12) L_☉). We present new far-infrared photometry, at 250, 350, and 500 μm (observed-frame), from the Herschel Space Telescope for a large sample of 113 DOGs with spectroscopically measured redshifts. Approximately 60% of the sample are detected in the far-IR. The Herschel photometry allows the first robust determinations of the total infrared luminosities of a large sample of DOGs, confirming their high IR luminosities, which range from 10^(11.6) L_☉ 10^(13) L_☉. The rest-frame near-IR (1-3 μm) spectral energy distributions (SEDs) of the Herschel-detected DOGs are predictors of their SEDs at longer wavelengths. DOGs with "power-law" SEDs in the rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to the QSO-like local ULIRG, Mrk 231. DOGs with a stellar "bump" in their rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to local star-bursting ULIRGs like NGC 6240. None show 250/24 μm flux density ratios similar to extreme local ULIRG, Arp 220; though three show 350/24 μm flux density ratios similar to Arp 220. For the Herschel-detected DOGs, accurate estimates (within ~25%) of total IR luminosity can be predicted from their rest-frame mid-IR data alone (e.g., from Spitzer observed-frame 24 μm luminosities). Herschel-detected DOGs tend to have a high ratio of infrared luminosity to rest-frame 8 μm luminosity (the IR8 = L_(IR)(8-1000 μm)/νL_ν(8 μm) parameter of Elbaz et al.). Instead of lying on the z = 1-2 "infrared main sequence" of star-forming galaxies (like typical LIRGs and ULIRGs at those epochs) the DOGs, especially large fractions of the bump sources, tend to lie in the starburst sequence. While, Herschel-detected DOGs are similar to scaled up versions of local ULIRGs in terms of 250/24 μm flux density ratio, and IR8, they tend to have cooler far-IR dust temperatures (20-40 K for DOGs versus 40-50 K for local ULIRGs) as measured by the rest-frame 80/115 μm flux density ratios (e.g., observed-frame 250/350 μm ratios at z = 2). DOGs that are not detected by Herschel appear to have lower observed-frame 250/24 μm ratios than the detected sample, either because of warmer dust temperatures, lower IR luminosities, or both

RPCs Considered Harmful

Scholars agree that amphibious configurations are an interesting new topic in the field of cryp- toanalysis, and mathematicians concur. After years of structured research into gigabit switches, we argue the improvement of forward-error correction, which embodies the private principles of cryptography. In our research, we use authenticated modalities to demonstrate that digital-to-analog converters and evolutionary programming can collude to address this question. Such a hypothesis at first glance seems unexpected but is derived from known results

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.

Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway. Smo has an extracellular cysteine-rich domain (CRD), indispensable for its function and downstream Hh signalling. Despite its essential role, the functional contribution of the CRD to Smo signalling has not been clearly elucidated. However, given that the FzD CRD binds to the endogenous Wnt ligand, it has been proposed that the Smo CRD may bind its own endogenous ligand. Here we present the NMR solution structure of the Drosophila Smo CRD, and describe interactions between the glucocorticoid budesonide (Bud) and the Smo CRDs from both Drosophila and human. Our results highlight a function of the Smo CRD, demonstrating its role in binding to small-molecule modulators

LEGUS Discovery of a Light Echo Around Supernova 2012aw

We have discovered a luminous light echo around the normal Type II-Plateau Supernova (SN) 2012aw in Messier 95 (M95; NGC 3351), detected in images obtained approximately two years after explosion with the Wide Field Channel 3 on-board the Hubble Space Telescope (HST) by the Legacy ExtraGalactic Ultraviolet Survey (LEGUS). The multi-band observations span from the near-ultraviolet through the optical (F275W, F336W, F438W, F555W, and F814W). The apparent brightness of the echo at the time was ~21--22 mag in all of these bands. The echo appears circular, although less obviously as a ring, with an inhomogeneous surface brightness, in particular, a prominent enhanced brightness to the southeast. The SN itself was still detectable, particularly in the redder bands. We are able to model the light echo as the time-integrated SN light scattered off of diffuse interstellar dust in the SN environment. We have assumed that this dust is analogous to that in the Milky Way with R_V=3.1. The SN light curves that we consider also include models of the unobserved early burst of light from the SN shock breakout. Our analysis of the echo suggests that the distance from the SN to the scattering dust elements along the echo is ~45 pc. The implied visual extinction for the echo-producing dust is consistent with estimates made previously from the SN itself. Finally, our estimate of the SN brightness in F814W is fainter than that measured for the red supergiant star at the precise SN location in pre-SN images, possibly indicating that the star has vanished and confirming it as the likely SN progenitor.Comment: 10 pages, 9 figures, to appear in the Astrophysical Journa

A complete view of galaxy evolution: panchromatic luminosity functions and the generation of metals

When and how did galaxies form and their metals accumulate? Over the last decade, this has moved from an archeological question to a live investigation: there is now a broad picture of the evolution of galaxies in dark matter halos: their masses, stars, metals and supermassive blackholes. Galaxies have been found and studied in which these formation processes are taking place most vigorously, all the way back in cosmic time to when the intergalactic medium (IGM) was still largely neutral. However, the details of how and why the interstellar medium (ISM) in distant galaxies cools, is processed, recycled and enriched in metals by stars, and fuels active galactic nuclei (AGNs) remain uncertain. In particular, the cooling of gas to fuel star formation, and the chemistry and physics of the most intensely active regions is hidden from view at optical wavelengths, but can be seen and diagnosed at mid- & far-infrared (IR) wavelengths. Rest-frame IR observations are important first to identify the most luminous, interesting and important galaxies, secondly to quantify accurately their total luminosity, and finally to use spectroscopy to trace the conditions in the molecular and atomic gas out of which stars form. In order to map out these processes over the full range of environments and large-scale structures found in the universe - from the densest clusters of galaxies to the emptiest voids - we require tools for deep, large area surveys, of millions of galaxies out to z~5, and for detailed follow-up spectroscopy. The necessary tools can be realized technically. Here, we outline the requirements for gathering the crucial information to build, validate and challenge models of galaxy evolution.Comment: A whitepaper submitted on 15th February 2009 in response to the call from the Astro2010 panel: astro2010.org; uploaded as an 8-page pdf fil

Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles: A Novel Non-Radioactive Method

Recent advances in nanotechnology have led to the development of biocompatible nanoparticles for in vivo molecular imaging and targeted therapy. Many nanoparticles have undesirable tissue distribution or unacceptably low serum half-lives. Pharmacokinetic (PK) and biodistribution studies can help inform decisions determining particle size, coatings, or other features early in nanoparticle development. Unfortunately, these studies are rarely done in a timely fashion because many nanotechnology labs lack the resources and expertise to synthesize radioactive nanoparticles and evaluate them in mice.To address this problem, we developed an economical, radioactivity-free method for assessing serum half-life and tissue distribution of nanoparticles in mice. Iron oxide nanoparticles coated with chitosan and polyethylene glycol that utilize chlorotoxin as a targeting molecule have a serum half-life of 7-8 hours and the particles remain stable for extended periods of time in physiologic fluids and in vivo. Nanoparticles preferentially distribute to spleen and liver, presumably due to reticuloendothelial uptake. Other organs have very low levels of nanoparticles, which is ideal for imaging most cancers in the future. No acute toxicity was attributed to the nanoparticles.We report here a simple near-infrared fluorescence based methodology to assess PK properties of nanoparticles in order to integrate pharmacokinetic data into early nanoparticle design and synthesis. The nanoparticles tested demonstrate properties that are excellent for future clinical imaging strategies and potentially suitable for targeted therapy