Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Generalized anxiety disorder (GAD) is the most frequent anxiety disorder in primary care patients. It is known that painful physical symptoms (PPS) are associated with GAD, regardless the presence of comorbid major depressive disorder (MDD). However the specific role of such symptoms in patients' functional impairment is not well understood. The objective of the present study is to assess functional impairment related to the presence of PPS in patients with GAD.</p> <p>Methods</p> <p>This is a post hoc analysis of a cross-sectional study. Functioning, in the presence (overall pain score >30; Visual Analog Scale) or absence of PPS, was assessed using the Sheehan Disability Scale (SDS) in three groups of patients; 1) GAD and comorbid MDD (GAD+MDD+), 2) GAD without comorbid MDD (GAD+MDD-), 3) controls (GAD-MDD-). ANCOVA models were used.</p> <p>Results</p> <p>Of those patients with GAD+MDD+ (n = 559), 436 (78.0%) had PPS, compared with GAD+MDD- (249 of 422, 59%) and controls (95 of 336, 28.3%). Functioning worsened in both GAD groups in presence of PPS (SDS least squares mean total score: 16.1 vs. 9.8, p < 0.0001, GAD+MDD+; 14.3 vs. 8.2, p < 0.0001, GAD+MDD-). The presence of PPS was significantly associated with less productivity.</p> <p>Conclusions</p> <p>Functional impairment related to the presence of PPS was relevant. Clinical implications should be considered.</p

Historical jurisprudence: an introduction to the systematic study of the development of law /

Mode of access: Internet

Source-book of English history : leading documents, together with illustrative material from contemporary writers and a bibliography of sources /

Includes index.Bibliography: p. 1-61.Mode of access: Internet

The true history of the Civil War,

Mode of access: Internet

Seven great hymns /

Sent out by Thomas Clemmitt, Jr., "as a Christmas souvenir, to a few friends and personal acquaintances, and to some others whom I know only by name...".Collation includes six blank leaves.Reprinted from the Baltimore Sun.Dies irae---De contemptu mundi---Stabat mater---Vexilla regis---Veni Sancte Spiritus---Veni Creator Spiritus---Te Deum laudamus---Cantemus cuncti.Mode of access: Internet

The history of North America.

Editors: v.1-8, 10-14, 17, Guy Carleton Lee. -- v. 9, 15-16, 18-20, Francis Newton Thorpe.Mode of access: Internet.SML : Library edition of which this set is number 653

Orators of America ...

"Limited to one thousand sets." This set not numbered.Collaborators: pt. 1, Franklin L. Riley. --pt. 2, C. Alphonso Smith. --pt. 3 Horatio Collins King

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present