Relationship Between Static Mobility of the First Ray and First Ray, Midfoot, and Hindfoot Motion During Gait

The relationship between a static measure of dorsal first ray mobility and dynamic motion of the first ray, midfoot, and hindfoot during the stance phase of walking was investigated in healthy, asymptomatic subjects who represented the spectrum of static flexibility. Static first ray mobility of 15 subjects was measured by a load cell device and ranged from stiff (3.1 mm) to lax (8.0 mm). Using three-dimensional motion analysis, mean first ray dorsiflexion/eversion and mid-/hindfoot eversion peak motion, time-to-peak, and eversion excursion were evaluated. Subjects with greater static dorsal mobility of the first ray demonstrated significantly greater time-topeak hindfoot eversion and eversion excursion (p \u3c .01), and midfoot peak eversion and eversion excursion (p \u3c .01). No significant association was found between static first ray mobility and first ray motion during gait. This research provides evidence that the dynamic response of the foot may modulate the consequences of first ray mobility and that compensory strategies are most effective when static measures of dorsal mobility are most extreme

The virtual microscopy database—sharing digital microscope images for research and education

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146335/1/ase1774_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146335/2/ase1774.pd

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery of chemotherapeutics agents and, in these studies, we apply this technology for therapeutic development in asthma. In these proof-of-concept experiments, we hypothesized that dexamethasone contained in self-assembling nanoparticles (Dex-NP) and delivered systemically would target the lung and decrease allergic lung inflammation and airways hyper-responsiveness to a greater degree than equivalent doses of dexamethasone (Dex) alone. We found that ovalbumin (Ova)-exposed mice treated with Dex-NP had significantly fewer total cells (2.78 ± 0.44 × 10(5) (n = 18) vs. 5.98 ± 1.3 × 10(5) (n = 13), P<0.05) and eosinophils (1.09 ± 0.28 × 10(5) (n = 18) vs. 2.94 ± 0.6 × 10(5) (n = 12), p<0.05) in the lung lavage than Ova-exposed mice alone. Also, lower levels of the inflammatory cytokines IL-4 (3.43 ± 1.2 (n = 11) vs. 8.56 ± 2.1 (n = 8) pg/ml, p<0.05) and MCP-1 (13.1 ± 3.6 (n = 8) vs. 28.8 ± 8.7 (n = 10) pg/ml, p<0.05) were found in lungs of the Dex-NP compared to control, and they were not lower in the Dex alone group. In addition, respiratory system resistance was lower in the Dex-NP compared to the other Ova-exposed groups suggesting a better therapeutic effect on airways hyperresponsiveness. Taken together, these findings from early-stage drug development studies suggest that the encapsulation and protection of anti-inflammatory agents such as corticosteroids in nanoparticle formulations can improve efficacy. Further development of novel drugs in nanoparticles is warranted to explore potential treatments for chronic inflammatory diseases such as asthma

Investigating the association between mating-relevant self-concepts and mate preferences through a data-driven analysis of online personal descriptions

Research on mate preference have often taken a theory-driven approach; however, such an approach can constrain the range of possible predictions. As a result, the research community may inadvertently neglect traits that are potentially important for human mate choice if current theoretical models simply do not identify them. Here, we address this limitation by using a data-driven approach to investigate mating-relevant self-concepts (i.e., what individuals believe to be attractive about themselves). Using Latent Dirichlet Allocation (LDA; a clustering method developed in computer science) and a large sample of written descriptions from online personal advertisements (N = 7,973), we identify 25 common topics that individuals use when advertising themselves. Men were more likely to advertise education/status, while women were more likely to discuss being honest/nurturing and caring for pets. We also assessed patterns of universal and compatible mate preferences for these 25 topics by collecting ratings of desirability from a separate group of 100 participants on a subset of these profiles (N = 468). Participants were also asked to write a personal description of themselves as if they were writing for a dating website. Overall, both male and female profiles that discussed outdoor activities, and music/art were rated as more desirable, while women that discussed a healthy lifestyle and friends/family were also rated as more desirable. Both men and women who discussed sex or mentioned being a parent were rated as less desirable. When comparing the topic probabilities between profiles collected online and those written by the raters, we found that raters preferred profiles that were more similar to their own, particularly for topics to do with being outgoing and agreeable

Individual-specific mortality is associated with how individuals evaluate future discounting decisions

How organisms discount the value of future rewards is associated with many important outcomes, and may be a central component of theories of life-history. According to life-history theories, prioritizing immediacy is indicative of an accelerated strategy (i.e. reaching reproductive maturity quickly and producing many offspring at the cost of long-term investment). Previous work extrapolating life-history theories to facultative calibration of life-history traits within individuals has theorized that cues to mortality can trigger an accelerated strategy; however, compelling evidence for this hypothesis in modern humans is lacking. We assessed whether country-level life expectancy predicts individual future discounting behaviour across multiple intertemporal choice items in a sample of 13 429 participants from 54 countries. Individuals in countries with lower life expectancy were more likely to prefer an immediate reward to one that is delayed. Individuals from countries with greater life expectancy were especially more willing to wait for a future reward when the relative gain in choosing the future reward was large and/or the delay period was short. These results suggest that cues to mortality can influence the way individuals evaluate intertemporal decisions, which in turn can inform life-history trade-offs. We also found that older (but not very old) participants were more willing to wait for a future reward when there is a greater relative gain and/or shorter delay period, consistent with theoretical models that suggest individuals are more future-orientated at middle age

Investigating the association between mating-relevant self-concepts and mate preferences through a data-driven analysis of online personal descriptions

Research on mate preference have often taken a theory-driven approach; however, such an approach can constrain the range of possible predictions. As a result, the research community may inadvertently neglect traits that are potentially important for human mate choice if current theoretical models simply do not identify them. Here, we address this limitation by using a data-driven approach to investigate mating-relevant self-concepts (i.e., what individuals believe to be attractive about themselves). Using Latent Dirichlet Allocation (LDA; a clustering method developed in computer science) and a large sample of written descriptions from online personal advertisements (N = 7,973), we identify 25 common topics that individuals use when advertising themselves. Men were more likely to advertise education/status, while women were more likely to discuss being honest/nurturing and caring for pets. We also assessed patterns of universal and compatible mate preferences for these 25 topics by collecting ratings of desirability from a separate group of 100 participants on a subset of these profiles (N = 468). Participants were also asked to write a personal description of themselves as if they were writing for a dating website. Overall, both male and female profiles that discussed outdoor activities, and music/art were rated as more desirable, while women that discussed a healthy lifestyle and friends/family were also rated as more desirable. Both men and women who discussed sex or mentioned being a parent were rated as less desirable. When comparing the topic probabilities between profiles collected online and those written by the raters, we found that raters preferred profiles that were more similar to their own, particularly for topics to do with being outgoing and agreeable

Analysis of Care Coordination for Children with Special Health Care Needs: A Parent\u27s Perspective

Introduction. Care coordination involves organizing patient care activities and sharing information among all of the participants concerned with a patient\u27s care to achieve improved outcomes, a recent national focus. Compared to the national average, a higher percentage of Vermont children are cared for in an office that meets medical home criteria. However, there is limited research on medical home and care coordination for children with special health care needs (CSHCN) in the state of Vermont. Objectives. The goal of this study was to assess family perceptions, knowledge, and attitudes about how well care coordination is working for Vermont families with CSHCN. Methods. A paper and an electronic anonymous survey was developed for Vermont families with CSHCN. The surveys were then distributed by Vermont Family Network and the UVMMC Department of Pediatrics. Focus group interviews were also conducted at Vermont Family Network to provide family insight to explain the quantitative data. Results. 30 participants responded to the survey; only 20 completed it. The overall composite satisfaction score is 54%. This score takes into account 4 questions regarding care coordination satisfaction. Each question was formatted into a numerical value ranging from zero to five, with an overall score of 20 equating to 100% satisfaction. Discussion. Findings indicate that families with CSHCN are not satisfied with the level of care coordination currently provided. Respondents reported many barriers regarding care coordination, including lack of communication among health care providers, insurance coverage, and lack of support during transitional periods in care. Recommended improvements were identified.https://scholarworks.uvm.edu/comphp_gallery/1251/thumbnail.jp

Are sex differences in preferences for physical attractiveness and good earning capacity in potential mates smaller in countries with greater gender equality?

On average, women show stronger preferences for mates with good earning capacity than men do, while men show stronger preferences for physically attractive mates than women do. Studies reporting that sex differences in mate preferences are smaller in countries with greater gender equality have been interpreted as evidence that these sex differences in mate preferences are caused by the different roles society imposes on men and women. Here we attempted to replicate previously reported links between sex differences in mate preferences and country-level measures of gender inequality in a sample of 3073 participants from 36 countries (data and code available at https://osf.io/4sr5f/). Although women preferred mates with good earning capacity more than men did and men preferred physically attractive mates more than women did, we found little evidence that these sex differences were smaller in countries with greater gender equality. Although one analysis suggested that the sex difference in preferences for good earning capacity was smaller in countries with greater gender equality, this effect was not significant when controlling for Galton’s problem or when correcting for multiple comparisons. Collectively, these results provide little support for the social roles account of sex differences in mate preferences

Shocked Gas in IRAS F17207-0014: ISM Collisions and Outflows

We combine optical and near-infrared AO-assisted integral field observations of the merging ULIRG IRAS F17207-0014 from the Wide-Field Spectrograph (WiFeS) and Keck/OSIRIS. The optical emission line ratios [N II]/H$\alpha$, [S II]/H$\alpha$, and [O I]/H$\alpha$ reveal a mixing sequence of shocks present throughout the galaxy, with the strongest contributions coming from large radii (up to 100% at $\sim$5 kpc in some directions), suggesting galactic-scale winds. The near-infrared observations, which have approximately 30 times higher spatial resolution, show that two sorts of shocks are present in the vicinity of the merging nuclei: low-level shocks distributed throughout our field-of-view evidenced by an H$_{2}$/Br$\gamma$ line ratio of $\sim$0.6-4, and strong collimated shocks with a high H$_{2}$/Br$\gamma$ line ratio of $\sim$4-8, extending south from the two nuclear disks approximately 400 pc ($\sim$0.5 arcsec). Our data suggest that the diffuse shocks are caused by the collision of the interstellar media associated with the two progenitor galaxies and the strong shocks trace the base of a collimated outflow coming from the nucleus of one of the two disks.Comment: accepted to MNRA

OT Practitioners’ and OT Students’ Perceptions of Entry-Level Competency for Occupational Therapy Practice

This study examined occupational therapy (OT) practitioners’ and OT students’ perceptions of the importance of 12 specific OT-related entry-level competency skills and the number of weeks required to consistently demonstrate skills for entry-level competency. The results indicated that, on average, practitioners (n = 39) and students (n = 38) agreed that all of the items were important. However, the students had significantly higher ratings regarding the importance of communication, occupation and client-centered goals, time management, interventions, and use of theory and evidence. They also rated a higher number of minimum weeks required to consistently demonstrate entry-level competency. The students who rated use of theory and evidence higher also rated a greater number of weeks to consistently demonstrate entry-level competency (Pearson r = .38; p= .02). The practitioners who rated psychosocial factors higher also rated a greater number of weeks to consistently demonstrate entry-level competency (Pearson r = .33, p = .04). These findings support the need for further research on defining entry-level competence and highlight the importance of communication between OT practitioners, students, and academic fieldwork coordinators to clarify which competencies are perceived as most important and the expectations regarding how long it takes for students to demonstrate them consistently