Integrated watershed management for mitigating streamflow depletion in an urbanized watershed in Korea

A systematic, seven-step approach to integrated watershed planning and management is applied to an urbanized watershed, the Anyangcheon (AY) watershed in Korea which consists of (1) understanding watershed components and processes, (2) identifying and ranking problems to be solved, (3) setting clear and specific goals, (4) developing a list of management options, (5) eliminating infeasible options (6) testing the effectiveness of remaining feasible options, and (7) developing the final options. Watershed characteristics, water quantity and quality simulations with SWAT and PLOAD models, and the developed problem indices of PFD (Potential Flood Damage), PSD (Potential Streamflow Depletion), and PWQD (Potential Water Quality Deterioration) identify that streamflow depletion is more serious than flood risk and water pollution in the study watershed (Steps 1 and 2). Instreamflow requirements, which are the maximum value of the average low flow and the fish flow, are estimated using regional regression and the software PHABSIM (Step 3). Feasible solutions that improve the depleted streams are listed and screened qualitatively against technical, economical, and environmental criteria (Steps 4 and 5). Effectiveness of the remaining 14 feasible alternatives are then analyzed using SWAT (Step 6) and alternative evaluation index (AEI) and their priority ranks are determined against an evaluation criterion that uses the concept of pressure, state, and response (Step 7)

Scattering of irregular waves by vertical cylinders

author's final versionAn analytical model has been developed that can predict the scattering of irregular waves normally incident upon an array of vertical cylinders. To examine the predictability of the developed model, laboratory experiments have been made for the reflection and transmission of irregular waves from arrays of circular cylinders with various diameters and gap widths. Though the overall agreement between measurement and calculation is fairly good, the model tends to over- and under-predict the reflection and transmission coefficients, respectively, as the gap width decreases. The model also underestimates the energy loss coefficients for small gap widths because it neglects the evanescent waves near the cylinders. The peaks of the measured spectra of the reflected and transmitted waves slightly shift towards higher frequencies compared with that of the incident wave spectrum probably because of the generation of shorter period waves due to the interference of the cylinders. Both model and experimental data show that the wave reflection and transmission become larger and smaller, respectively, as the wave steepness increases, which is a desirable feature of the cylinder breakwaters

Fluid-filled Giant Bulla Treated with Percutaneous Drainage and Talc Sclerotherapy: A Modified Brompton Technique

A 75-year-old man who was diagnosed as having a fluid-filled giant bulla was treated with a modified Brompton technique due to his poor performance status. Percutaneous drainage, suction, and talc sclerotherapy through a Foley catheter can be good treatment options for patients with conditions that are too poor to allow surgical intervention, especially if there is adhesion between a giant bulla and parietal pleura. Talc can also be used safely when mixed with normal saline as a sclerosant

Anticancer Effect of Nemopilema nomurai

Various kinds of animal venoms and their components have been widely studied for potential therapeutic applications. This study evaluated whether Nemopilema nomurai jellyfish venom (NnV) has anticancer activity. NnV strongly induced cytotoxicity of HepG2 cells through apoptotic cell death, as demonstrated by alterations of chromatic morphology, activation of procaspase-3, and an increase in the Bax/Bcl-2 ratio. Furthermore, NnV inhibited the phosphorylation of PI3K, PDK1, Akt, mTOR, p70S6K, and 4EBP1, whereas it enhanced the expression of p-PTEN. Interestingly, NnV also inactivated the negative feedback loops associated with Akt activation, as demonstrated by downregulation of Akt at Ser473 and mTOR at Ser2481. The anticancer effect of NnV was significant in a HepG2 xenograft mouse model, with no obvious toxicity. HepG2 cell death by NnV was inhibited by tetracycline, metalloprotease inhibitor, suggesting that metalloprotease component in NnV is closely related to the anticancer effects. This study demonstrates, for the first time, that NnV exerts highly selective cytotoxicity in HepG2 cells via dual inhibition of the Akt and mTOR signaling pathways, but not in normal cells

Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma

A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow-derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumor-free mice were able to resist a repeat challenge with the same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma

Genome-wide identification of long non-coding RNAs in tomato plants irradiated by neutrons followed by infection with Tomato yellow leaf curl virus

Long non-coding RNAs (lncRNAs) play an important role in regulating many biological processes. In this study, tomato seeds were first irradiated by neutrons. Eight tomato mutants were then selected and infected by Tomato yellow leaf curl virus (TYLCV). RNA sequencing followed by bioinformatics analyses identified 1,563 tomato lncRNAs. About half of the lncRNAs were derived from intergenic regions, whereas antisense lncRNAs accounted for 35%. There were fewer lncRNAs identified in our study than in other studies identifying tomato lncRNAs. Functional classification of 794 lncRNAs associated with tomato genes showed that many lncRNAs were associated with binding functions required for interactions with other molecules and localized in the cytosol and membrane. In addition, we identified 19 up-regulated and 11 down-regulated tomato lncRNAs by comparing TYLCV infected plants to non-infected plants using previously published data. Based on these results, the lncRNAs identified in this study provide important resources for characterization of tomato lncRNAs in response to TYLCV infection

Effect of Zoledronic Acid on Acro-Osteolysis and Osteoporosis in a Patient with Hajdu-Cheney Syndrome

Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself