Example of solvable quantum groups and their representations

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1994.Includes bibliographical references (p. 38).by Calvin L. Roth.M.S

Cancer Niche as a Garbage Disposal Machine: Implications of TCM-Mediated Balance of Body-Disease for Treatment of Cancer.

Cancer epidemic led to worldwide to search for a new "game changer" concept to govern cancer research and cancer treatment. Western medicine-based cancer research has been extending the impasse without resolution in sigh for improving survival of patients with solid malignant tumors in the last four decades due to heterogeneity in cancer tissues. Such a deadlock charts a course to learn lessons from the developing countries, directly or indirectly to complement the exhausted Western medicine. We propose a new concept of "Cancer niche as a garbage disposal machine" with implications of traditional Chinese medicine-mediated restoration of normal balance between body and disease to bring the fight against cancer under control

Designing for Safer Work Zones

This presentation will take you through the yearlong joint cooperative process between industry and state government that is making our work zones safer. Projects are being designed and executed in a safer manner as all concerned are taking a proactive approach to address the spike in incidents and fatalities in our work zones. The results and ongoing efforts of this large-scale, multi-jurisdictional effort will be addressed

MODIFICATION OF THE NUCLEOTIDE COFACTOR-BINDING SITE OF CYTOCHROME P450 REDUCTASE TO ENHANCE TURNOVER WITH NADH IN VIVO

NADPH-cytochrome P450 reductase is the electron transfer partner for the cytochromes P450, heme oxygenase, and squalene monooxygenase, and is a component of the nitric oxide synthases and methionine synthase reductase. P450 reductase shows very high selectivity for NADPH and uses NADH only poorly. Substitution of tryptophan 677 with alanine (W677A) has been shown by others to yield a 3-fold increase in turnover with NADH, but profound inhibition by NADP+ makes the enzyme unsuitable for in vivo applications. In the present study site-directed mutagenesis of amino acids in the 2\u27-phosphate-binding site of the NADPH domain, coupled with the W677A substitution, was used to generate a reductase that was able to use NADH efficiently in vivo without inhibition by NADP+. Of 11 single, double, and triple mutant proteins, two (R597M/W677A and R597M/K602W/W677A) showed up to a 500-fold increase in catalytic efficiency (kcat/Km) with NADH. Inhibition by NADP+ was reduced by up to four orders of magnitude relative to the W677A protein and was equal to or less than that of the wild-type reductase. Both proteins were 2- to 3-fold more active than wild-type reductase with NADH in reconstitution assays with cytochrome P450 1A2 and with squalene monooxygenase. In a recombinant cytochrome P450 2E1 Ames bacterial mutagenicity assay the R597M/W677A protein increased the sensitivity to dimethylnitrosamine by approximately 2-fold, suggesting that the ability to use NADH afforded a significant advantage in this in vivo assay. In addition to providing a valuable tool for understanding the determinants of nucleotide cofactor specificity in this and related enzymes, these mutants might also lend themselves to creation of bioremediation schemes with increased enzymatic activity and robustness in situ, as well as cost-effective reconstitution of enzyme systems in vitro that do not require the use of expensive reducing equivalents from NADPH

Designing Safer Work Zones

This presentation will take you through the yearlong joint cooperative process between industry and state government that is making our work zones safer. Projects are being designed and executed in a safer manner as all concerned are taking a proactive approach to address the spike in incidents and fatalities in our work zones. The results and ongoing efforts of this large-scale, multi-jurisdictional effort will be addressed

Designing Safer Work Zones

This presentation will take you through the yearlong joint cooperative process between industry and state government that is making our work zones safer. Projects are being designed and executed in a safer manner as all concerned are taking a proactive approach to address the spike in incidents and fatalities in our work zones. The results and ongoing efforts of this large-scale, multi-jurisdictional effort will be addressed

Perceptions of institutional influence on the scalability of social enterprise: a study of social entrepreneurial practise in the South African food Industry

A dissertation submitted in fulfilment of the requirements for the degree of Master of Commerce by Research in the field of Management to the Faculty of Commerce, Law and Management, University of the Witwatersrand, Johannesburg, June 2017The field of social entrepreneurship is gaining prominence in academic research through its ability to drive innovation and solve complex societal problems. There is a growing interest in this field due to the inherent appeal of entrepreneurship as well as the need to address social inequalities. However, despite the growing interest in social entrepreneurship, there is limited academic research in the subject – especially with regards to the nexus between institutional influence and scale of social enterprise. The majority of social entrepreneurial endeavours in South Africa are found in the food industry. Despite the magnitude of the role that social entrepreneurs play in this industry, research remains limited. Definitional debates with a bias towards conceptual research over empirical research dominates current study on social entrepreneurship – resulting in a lack of consensus among researchers on what social entrepreneurship means. In addition to the above, social entrepreneurship literature has devoted insufficient empirical and theoretical work to the study of scaling of social impact. The majority of the theoretical work has been geared towards the development of practitioner frameworks. The empirical research in the field has also been limited, specifically with regards to understanding the drivers of successful scaling of social entrepreneurial organisations. The majority of these empirical studies have utilised comparative case study approaches. Using institutional theory as a lens, this research aimed to develop a conceptual framework that can be utilised by social entrepreneurs, as well as relevant stakeholders in order to promote the scale of individual social enterprises, particularly in the South African food industry, by developing a “roadmap” to scaling. In addition to the above, the focus was on food security in the South African food industry. It is intended that the conceptual framework can indirectly address the broader societal issues surrounding food security. The above was achieved through a qualitative study. Perceptions of institutional influence on scale as well as start-ups, and drivers of scale were identified through conducting a literature review. A conceptual framework was then established from these constructs. The next step involved conducting semi-structured interviews with 14 social entrepreneurs in the food industry to validate the constructs, and identify the relationships between the constructs. The data was then analysed using the Interpretative Phenomenological approach. The result of the qualitative research is a conceptual research framework, with certain hypotheses. The empirical study identified social innovation as well as the implementation of impactful governmental policies as the most critical institutional influencers of scale. In addition, using SCALERS model as a reference, the empirical study identified lobbying, alliance building, and staffing as drivers to scale. It is noted that that lobbying and alliance building can be linked to government policies as it relates to the collaboration of social enterprises in order to influence policymakers, in addition, staffing relates to the use of volunteers to bring new innovative solutions to the business – these drivers of scale (based on SCALERS model) reinforce the identified institutional influences as critical to scale. If all of the above are present, with all things being equal, then social ventures are more likely to scale – resulting in economic growth and in addition, social issues such as food security will be addressed. From a social entrepreneurship perspective, this study made a substantial contribution in shifting the social entrepreneurship research focus from conceptual, definition biased research towards empirical research that strengthened theoretical research on social entrepreneurship.XL201

TECHNOLOGY INTEGRATION IN AN INDONESIAN EFL WRITING CLASSROOM

The global, national, and local top-down technology-related policies and initiatives indicate the essential place of technology in education. However, little is known about classroom-based and self-reflective understandings of how the integration of technology can facilitate or distract students’ writing processes in the context of higher education in Indonesia, specifically from the eyes of English as a Foreign Language (EFL) writing lecturers in the country. In response, this qualitative study aims to delve closely into the lecturers’reflection of integrating technology to support their students in completing English language learning tasks in an EFL writing classroom. Data were gathered from three female writing lecturers. They completed four self-reflective checklists and were interviewed to clarify the checklists and their technological practices related to five stages of process writing, namely planning, drafting, editing, revising, and submitting. The analysis of the data indicated that the most successful experiences in using technology were in the planning stage. Meanwhile, technology applications in the drafting, editing, and revising phases were mainly used to submit work and provide feedback. Various technology applications used in the writing class, some issues in using the technology in the writing stages, and directions for further research are discussed

Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine.

Rising concerns about the short- and long-term detrimental consequences of administration of conventional pharmacopeia are fueling the search for alternative, complementary, personalized, and comprehensive approaches to human healthcare. Qigong, a form of Traditional Chinese Medicine, represents a viable alternative approach. Here, we started with the practical, philosophical, and psychological background of Ki (in Japanese) or Qi (in Chinese) and their relationship to Qigong theory and clinical application. Noting the drawbacks of the current state of Qigong clinic, herein we propose that to manage the unique aspects of the Eastern 'non-linearity' and 'holistic' approach, it needs to be integrated with the Western "linearity" "one-direction" approach. This is done through developing the concepts of "Qigong breathing signatures," which can define our life breathing patterns associated with diseases using machine learning technology. We predict that this can be achieved by establishing an artificial intelligence (AI)-Medicine training camp of databases, which will integrate Qigong-like breathing patterns with different pathologies unique to individuals. Such an integrated connection will allow the AI-Medicine algorithm to identify breathing patterns and guide medical intervention. This unique view of potentially connecting Eastern Medicine and Western Technology can further add a novel insight to our current understanding of both Western and Eastern medicine, thereby establishing a vitality score index (VSI) that can predict the outcomes of lifestyle behaviors and medical conditions