Single-Species Three-Particle Reactions in One Dimension

Renormalization group calculations for fluctuation-dominated reaction-diffusion systems are generally in agreement with simulations and exact solutions. However, simulations of the single-species reactions 3A->(0,A,2A) at their upper critical dimension d_c=1 have found asymptotic densities argued to be inconsistent with renormalization group predictions. We show that this discrepancy is resolved by inclusion of the leading corrections to scaling, which we derive explicitly and show to be universal, a property not shared by the A+A->(0,A) reactions. Finally, we demonstrate that two previous Smoluchowski approaches to this problem reduce, with various corrections, to a single theory which yields, surprisingly, the same asymptotic density as the renormalization group.Comment: 8 pages, 5 figs, minor correction

Crosslinking-induced endocytosis of acetylcholine receptors by quantum dots

In a majority of patients with myasthenia gravis (MG), anti-acetylcholine receptor (AChR) antibodies target postsynaptic AChR clusters and thus compromise the membrane integrity of neuromuscular junctions (NMJs) and lead to muscle weakness. Antibody-induced endocytosis of AChRs in the postsynaptic membrane represents the initial step in the pathogenesis of MG; however, the molecular mechanisms underlying AChR endocytosis remain largely unknown. Here, we developed an approach to mimic the pathogenic antibodies for inducing the crosslinking and internalization of AChRs from the postsynaptic membrane. Using biotin-α-bungarotoxin and quantum dot (QD)-streptavidin, cell-surface and internalized AChRs could be readily distinguished by comparing the size, fluorescence intensity, trajectory, and subcellular localization of the QD signals. QD-induced AChR endocytosis was mediated by clathrin-dependent and caveolin-independent mechanisms, and the trafficking of internalized AChRs in the early endosomes required the integrity of microtubule structures. Furthermore, activation of the agrin/MuSK (muscle-specific kinase) signaling pathway strongly suppressed QD-induced internalization of AChRs. Lastly, QD-induced AChR crosslinking potentiated the dispersal of aneural AChR clusters upon synaptic induction. Taken together, our results identify a novel approach to study the mechanisms of AChR trafficking upon receptor crosslinking and endocytosis, and demonstrate that agrin-MuSK signaling pathways protect against crosslinking-induced endocytosis of AChRs. © 2014 Lee et al.published_or_final_versio

Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma

Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability. Despite this association between centrosome abnormalities and cancerous growth, a causative role of centrosome aberrations in generating chromosomal instability and aneuploidy has not been universally established. We report here excessive numerical and structural centrosome abnormalities in a malignant Burkitt's lymphoma harboring the characteristic t(8;14) chromosomal translocation. Using conventional karyotyping and fluorescence in situ hybridization (FISH), we detected no signs of ongoing numerical chromosome instability, although the tumor displayed sporadic multipolar metaphases. These findings demonstrate that centrosome abnormalities are not a universal surrogate marker for chromosomal instability in malignant tumors. Moreover, our results suggest a model in which additional cellular alterations may be required to promote centrosome-related mitotic defects in tumor cells

From Molecular Cores to Planet-forming Disks with SIRTF

The SIRTF mission and the Legacy programs will provide coherent data bases for extra-galactic and Galactic science that will rapidly become available to researchers through a public archive. The capabilities of SIRTF and the six legacy programs are described briefly. Then the cores to disks (c2d) program is described in more detail. The c2d program will use all three SIRTF instruments (IRAC, MIPS, and IRS) to observe sources from molecular cores to protoplanetary disks, with a wide range of cloud masses, stellar masses, and star-forming environments. The SIRTF data will stimulate many follow-up studies, both with SIRTF and with other instruments.Comment: 6 pages, from Fourth Cologne-Bonn-Zermatt-Symposium, The Dense Interstellar Matter in Galaxie

Towards an Experimental Bibliography of Hemispheric Reconstruction Newspapers

Digital collections of newspapers have drawn broader attention to the fragmented and scattered print histories of minoritized communities. Attempts to survey these histories through bibliography, however, quickly meet with a fundamental problem: the practice of bibliographic description calls for creating a static record of social affiliations. Given the overwhelming scholarly consensus that categories such as race, ethnicity, and language are socially constructed, this article introduces an experimental bibliographic method for mapping the vast landscape of historical newspapers. This method extends the machine learning affordances of a recent project called Newspaper Navigator to enumerate the newspapers in Chronicling America according to the visual similarity of their layouts. After explaining this method, the authors delve into the unsettled formats of one unruly example, a Spanish-language newspaper in Los Angeles, California, called La Crónica (1872–92). La Crónica changed its formats many times over the years as part of the paper’s ambitions for political influence or commercial appeal. Experimental mapping and closer analysis demonstrate that a more iterative bibliographic approach can help us better understand the serial craft of newspapers and, by extension, the force of print in forming communities. (In the issue section Rethinking Catalogs and Archives

Parity Problem With A Cellular Automaton Solution

The parity of a bit string of length $N$ is a global quantity that can be efficiently compute using a global counter in ${O} (N)$ time. But is it possible to find the parity using cellular automata with a set of local rule tables without using any global counter? Here, we report a way to solve this problem using a number of $r=1$ binary, uniform, parallel and deterministic cellular automata applied in succession for a total of ${O} (N^2)$ time.Comment: Revtex, 4 pages, final version accepted by Phys.Rev.

Dilemma and Quantum Battle of Sexes

We analysed quantum version of the game battle of sexes using a general initial quantum state. For a particular choice of initial entangled quantum state it is shown that the classical dilemma of the battle of sexes can be resolved and a unique solution of the game can be obtained.Comment: Revised, Latex, 9 pages, no figure, corresponding author's email: [email protected]

Electronic decoupling of an epitaxial graphene monolayer by gold intercalation

The application of graphene in electronic devices requires large scale epitaxial growth. The presence of the substrate, however, usually reduces the charge carrier mobility considerably. We show that it is possible to decouple the partially sp3-hybridized first graphitic layer formed on the Si-terminated face of silicon carbide from the substrate by gold intercalation, leading to a completely sp2-hybridized graphene layer with improved electronic properties.Comment: 7 pages, 4 figures, 1 tabl

Model-based asymptotically optimal dispersion measure correction for pulsar timing

In order to reach the sensitivity required to detect gravitational waves, pulsar timing array experiments need to mitigate as much noise as possible in timing data. A dominant amount of noise is likely due to variations in the dispersion measure. To correct for such variations, we develop a statistical method inspired by the maximum likelihood estimator and optimal filtering. Our method consists of two major steps. First, the spectral index and amplitude of dispersion measure variations are measured via a time-domain spectral analysis. Second, the linear optimal filter is constructed based on the model parameters found in the first step, and is used to extract the dispersion measure variation waveforms. Compared to current existing methods, this method has better time resolution for the study of short timescale dispersion variations, and generally produces smaller errors in waveform estimations. This method can process irregularly sampled data without any interpolation because of its time-domain nature. Furthermore, it offers the possibility to interpolate or extrapolate the waveform estimation to regions where no data is available. Examples using simulated data sets are included for demonstration.Comment: 15 pages, 15 figures, submitted 15th Sept. 2013, accepted 2nd April 2014 by MNRAS. MNRAS, 201