The Grizzly, December 6, 2018

Snapchat Story Leads to School Enforcement of Discriminatory Acts Policy • What\u27s in Store for Martin Luther King, Jr. Week • Ursinus Celebrated the Fifth Annual #Giving2UCday on Campus • Student Employee Profiles: Facilities • The Curtain Club and how Theatre Evolved at Ursinus • Opinions: It\u27s Time to Retire the War on Christmas ; Let Students Spend Dining Dollars Off-Campus • Athlete Spotlight: Junior Quarterback Tom Garlick • Eric Williams Jr. Knocks Down 1,000th Career Point for UC Men\u27s Basketballhttps://digitalcommons.ursinus.edu/grizzlynews/1610/thumbnail.jp

The Grizzly, November 8, 2018

UC\u27s First African-American Graduate Passes Away: W. Robert Crigler Graduated from Ursinus in 1956 • This is Their Home and They Belong Here : Ursinus Released a Statement Affirming the Rights of Trans Students in the Wake of Threats from President Trump • What\u27s Happening in Honduras? • Ursinus Introduces Vice President of Enrollment, Shannon Zottola • The Reader\u27s Recovery • The Cubed Curve • Opinions: Latin America Deserves Better Response from the U.S.; Ritter Should be the Next Update to Campus • Athlete Spotlight: Gabriela Howell • Men\u27s Basketball Participates in The Programhttps://digitalcommons.ursinus.edu/grizzlynews/1607/thumbnail.jp

The Grizzly, October 25, 2018

New Discriminatory Act Policy Draws Criticism • Radium Girls Will Take the Stage this November • Good and Bad News on Campus Safety • Dr. Tristan Ashcroft Receives Teaching Excellence Award • L.A.X. Strives to Meet the Need for Representation of Latin American Culture on Campus • Meet Quinn Gilman-Forlini • Opinion: The Romanoffs : Death Knell for Streamable Prestige TV • Highlights from the Annual Securities and Fire Safety Report • Fresh-faced UC Women\u27s Rugby Team Continues to Show Improvement • He\u27s Good: Senior Kirk Cherneskie Nails Transition from Linebacker to Kickerhttps://digitalcommons.ursinus.edu/grizzlynews/1605/thumbnail.jp

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity

Expiratory flow limitation during exercise in COPD: detection by manual compression of the abdominal wall.

Manual compression of the abdomen (MCA) during spontaneous expiration is a simple method for the detection of flow limitation in the chronic obstructive pulmonary disease (COPD) patients during resting breathing, based on comparison of flow/volume curves obtained during MCA with that of the preceding control breath. It was assessed whether this nonstandardized technique is also feasible during exercise. MCA was performed during resting breathing and constant-exercise work at one- and two-thirds maximal mechanical power output (W'max) in six normal subjects and 12 COPD patients. Changes in end-expiratory lung volume (EELV) were also studied. With the aid of inspection, abdominal palpation and lung auscultation, MCA could always be applied during expiration. Flow limitation was never detected in the six normal subjects, whereas four of the COPD patients were flow limited at rest, seven during exercise at one-third W'max and nine during exercise at two-thirds W'max. Expiratory flow limitation detected by MCA was always associated with an increase in EELV during exercise, indicating dynamic hyperinflation occurrence or increase. It is concluded that manual compression of the abdomen is a very simple and reliable method for the detection of flow limitation during exercise.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Mise en évidence de la limitation des débits expiratoires à l'effort par la compression abdominale manuelle (CAM)

info:eu-repo/semantics/nonPublishe

Detection of expiratory flow limitation during exercise in COPD patients using manual compression of the abdominal wall

info:eu-repo/semantics/nonPublishe

Detection of expiratory flow limitation by manual compression of the abdominal wall

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer

Although invasive ductal breast cancer (IDC) represents the most common histological type of breast cancer, minor subtypes exist such as mucinous breast cancer (MuBC). MuBC are distinguished by tumor cells floating in extracellular mucin. MuBC patients are generally older and associated with a favorable prognosis. To unravel the molecular architecture of MuBC, we applied low-pass whole-genome sequencing and microscopic evaluation of stromal tumor infiltrating lymphocytes to 30 MuBC from a retrospective institutional cohort. We further analyzed two independent datasets from the International Cancer Genomics Consortium and The Cancer Genome Atlas. Genomic data (n = 26 MuBC, n = 535 estrogen receptor [ER] positive/HER2-negative IDC), methylation data (n = 28 MuBC, n = 529 ER-positive/HER2-negative IDC), and transcriptomic data (n = 27 MuBC, n = 467 ER-positive/HER2-negative IDC) were analyzed. MuBC was characterized by low tumor infiltrating lymphocyte levels (median = 0.0%, average = 3.4%, 95% confidence interval = 1.9% to 4.9%). Compared with IDC, MuBC had a lower genomic instability (P = .01, two-sided Mann-Whitney U test) and a decreased prevalence of PIK3CA mutations (39.7% in IDC vs 6.7% in MuBC, P = .01 in the International Cancer Genomics Consortium; and 34.8% vs 0.0%, P = .02 in The Cancer Genome Atlas, two-sided Fisher's exact test). Finally, our report identifies aberrant DNA methylation of MUC2 as a possible cause of extracellular production of mucin in MuBC.status: publishe

Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer

Although invasive ductal breast cancer (IDC) represents the most common histological type of breast cancer, minor subtypes exist such as mucinous breast cancer (MuBC). MuBC are distinguished by tumor cells floating in extracellular mucin. MuBC patients are generally older and associated with a favorable prognosis. To unravel the molecular architecture of MuBC, we applied low-pass whole-genome sequencing and microscopic evaluation of stromal tumor infiltrating lymphocytes to 30 MuBC from a retrospective institutional cohort. We further analyzed two independent datasets from the International Cancer Genomics Consortium and The Cancer Genome Atlas. Genomic data (n = 26 MuBC, n = 535 estrogen receptor [ER] positive/HER2-negative IDC), methylation data (n = 28 MuBC, n = 529 ER-positive/HER2-negative IDC), and transcriptomic data (n = 27 MuBC, n = 467 ER-positive/HER2-negative IDC) were analyzed. MuBC was characterized by low tumor infiltrating lymphocyte levels (median = 0.0%, average = 3.4%, 95% confidence interval = 1.9% to 4.9%). Compared with IDC, MuBC had a lower genomic instability (P =. 01, two-sided Mann-Whitney U test) and a decreased prevalence of PIK3CA mutations (39.7% in IDC vs 6.7% in MuBC, P =. 01 in the International Cancer Genomics Consortium; and 34.8% vs 0.0%, P =. 02 in The Cancer Genome Atlas, two-sided Fisher's exact test). Finally, our report identifies aberrant DNA methylation of MUC2 as a possible cause of extracellular production of mucin in MuBC.SCOPUS: ar.jinfo:eu-repo/semantics/publishe