The impact of information systems on work structure and culture in an emergency department

This paper describes a study where consultants in an emergency department will be observed and interviewed with the aim of evaluating the impact of the progressive implementation of an information system in an emergency department in a metropolitan hospital in Australia. The study is the third stage of a 3-stage longitudinal study which is building on data from two previous studies that were conducted in the same setting in 2008 and 2012. The evaluations will be based on predefined task categories to investigate how information systems in health settings affect time and prioritisation of tasks. The study aims to understand how the changes brought by information systems implementation can be managed to fit in with the structure and culture of work in the hospital setting. The outcome of this research will inform guidelines for how information systems for hospitals can be designed and implemented

The Development of Vaginal Microbicides for the Prevention of HIV Transmission

Given that we still do not have an effective vaccine against HIV, the development of novel biomedical methods for preventing HIV transmission remains a top priority in controlling the HIV pandemic

Gamificação: Framework Concetual para Cursos Online de Aprendizagem da Programação

Trabalho apresentado na CISTI'2017 - 12ª Conferência Ibérica de Sistemas e Tecnologias de Informação, 21-24 de junho, Lisboa, PortugalA gamificação tem atraído a atenção de investigadores das mais diversas áreas, como marketing, saúde, desporto e educação. A gamificação integra elementos de desenho de jogos em contexto de não jogo com a finalidade de envolver o indivíduo numa determinada atividade. Essa integração deverá seguir um processo de desenho formal e claro. Contudo, esses processos de desenho da gamificação para contextos específicos não estão ainda definidos. Nesse sentido, este artigo apresenta uma proposta de framework de gamificação para cursos online à distância, de aprendizagem da programação. Esta framework é composta pelas dimensões: público-alvo, objetivos gerais, resultados da aprendizagem, tópicos, conteúdos, gamificação, absorção cognitiva, fluxo e personalidade. O artigo apresenta ainda uma revisão da literatura existente sobre estas dimensões. A framework teórica é uma contribuição para guiar os professores na gamificação dos cursos online de aprendizagem de programação.N/

Factors Associated With Viral Rebound in HIV-1-Infected Individuals Enrolled in a Therapeutic HIV-1 \u3ci\u3egag\u3c/i\u3e Vaccine Trial

Background. Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression. Methods. Randomized, placebo-controlled trial involving HIV-1-infected participants who received a recombinant adenovirus serotype 5 (rAd5) HIV-1 gag vaccine or placebo. Sequence-based HLA typing was performed for all 110 participants who initiated analytic treatment interruption (ATI) to assess the role of HLA types previously associated with HIV prognosis. Plasma HIV-1 gag and pol RNA sequences were obtained during the ATI. Virologic endpoints and HLA groups were compared between treatment arms using the 2-sample rank sum test. A linear regression model was fitted to derive independent correlates of ATI week 16 plasma viral load (w16 PVL). Results. Vaccinated participants with neutral HLA alleles had lower median w16 PVLs than did vaccinated participants with protective HLA alleles (P 5 .01) or placebo participants with neutral HLA alleles (P 5 .02). Factors independently associated with lower w16 PVL included lower pre-antiretroviral therapy PVL, greater Gag sequence divergence from the vaccine sequence, decreased proportion of HLA-associated polymorphisms in Gag, and randomization to the vaccine arm. Conclusions. Therapeutic vaccination with a rAd5-HIV gag vaccine was associated with lower ATI week 16 PVL even after controlling for viral and host genetic factors

Factors Associated With Viral Rebound in HIV-1-Infected Individuals Enrolled in a Therapeutic HIV-1 \u3ci\u3egag\u3c/i\u3e Vaccine Trial

Background. Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression. Methods. Randomized, placebo-controlled trial involving HIV-1-infected participants who received a recombinant adenovirus serotype 5 (rAd5) HIV-1 gag vaccine or placebo. Sequence-based HLA typing was performed for all 110 participants who initiated analytic treatment interruption (ATI) to assess the role of HLA types previously associated with HIV prognosis. Plasma HIV-1 gag and pol RNA sequences were obtained during the ATI. Virologic endpoints and HLA groups were compared between treatment arms using the 2-sample rank sum test. A linear regression model was fitted to derive independent correlates of ATI week 16 plasma viral load (w16 PVL). Results. Vaccinated participants with neutral HLA alleles had lower median w16 PVLs than did vaccinated participants with protective HLA alleles (P 5 .01) or placebo participants with neutral HLA alleles (P 5 .02). Factors independently associated with lower w16 PVL included lower pre-antiretroviral therapy PVL, greater Gag sequence divergence from the vaccine sequence, decreased proportion of HLA-associated polymorphisms in Gag, and randomization to the vaccine arm. Conclusions. Therapeutic vaccination with a rAd5-HIV gag vaccine was associated with lower ATI week 16 PVL even after controlling for viral and host genetic factors