216 research outputs found
A prospective longitudinal study of perceived infant outcomes at 18-24 months: Neural and psychological correlates of parental thoughts and actions assessed during the first month postpartum
The first postpartum months constitute a critical period for parents to establish an emotional bond with their infants. Neural responses to infant-related stimuli have been associated with parental sensitivity. However, the associations among these neural responses, parenting, and later infant outcomes for mothers and fathers are unknown. In the current longitudinal study, we investigated the relationships between parental thoughts/actions and neural activation in mothers and fathers in the neonatal period with infant outcomes at the toddler stage. At the first month postpartum, mothers (n=21) and fathers (n=19) underwent a neuroimaging session during which they listened to their own and unfamiliar babyâs cry. Parenting-related thoughts/behaviors were assessed by interview twice at the first month and 3-4 months postpartum and infantsâ socioemotional outcomes were reported by mothers and fathers at 18-24 months postpartum. In mothers, higher levels of anxious thoughts/actions about parenting at the first month postpartum, but not at 3-4 months postpartum, were associated with infantâs low socioemotional competencies at 18-24 months. Anxious thoughts/actions were also associated with heightened responses in the motor cortex and reduced responses in the substantia nigra to own infant cry sounds. On the other hand, in fathers, higher levels of positive perception of being a parent at the first month postpartum, but not at 3-4 months postpartum, were associated with higher infant socioemotional competencies at 18-24 months. Positive thoughts were associated with heightened responses in the auditory cortex and caudate to own infant cry sounds. The current study provides evidence that parental thoughts are related to concurrent neural responses to their infants at the first month postpartum as well as their infantâs future socioemotional outcome at 18-24 months. Parent differences suggest that anxious thoughts in mothers and positive thoughts in fathers may be the targets for parenting-focused interventions very early postpartum
Primary maternal preoccupation revisited: circuits, genes, and the crucial role of early life experience
Parental caregiving includes a set of highly conserved set of behaviors and mental states that may reflect both an individualâs genetic endowment and the early experience of being cared for as a child. This review first examines the mental and behavioral elements of early parental caregiving in humans. Second, we consider what is known of the neurobiological substrates of maternal behaviors in mammalian species including some limited human data. Third, we briefly review the evidence that specific genes encode proteins that are crucial for the development of the neural substrates that underlie specific features of maternal behavior. Fourth, we review the literature on the âprogrammingâ role of epigenetic factors in shaping subsequent maternal behavior. We conclude that there are critical developmental windows during which the genetically determined microcircuitry of key limbic-hypothalamic-midbrain structures are susceptible to early environmental influences and that these influences powerfully shape an individualâs responsivity to psychosocial stressors and their resiliency or vulnerability to various forms of human psychopathology later in life.South African Psychiatry Review - May 200
Perceived quality of maternal care in childhood and structure and function of mothers' brain
Animal studies indicate that early maternal care has long-term effects on brain areas related to social attachment and parenting, whereas neglectful mothering is linked with heightened stress reactivity in the hippocampus across the lifespan. The present study explores the possibility, using magnetic resonance imaging, that perceived quality of maternal care in childhood is associated with brain structure and functional responses to salient infant stimuli among human mothers in the first postpartum month. Mothers who reported higher maternal care in childhood showed larger grey matter volumes in the superior and middle frontal gyri, orbital gyrus, superior temporal gyrus and fusiform gyrus. In response to infant cries, these mothers exhibited higher activations in the middle frontal gyrus, superior temporal gyrus and fusiform gyrus, whereas mothers reporting lower maternal care showed increased hippocampal activations. These findings suggest that maternal care in childhood may be associated with anatomy and functions in brain regions implicated in appropriate responsivity to infant stimuli in human mothers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79249/1/j.1467-7687.2009.00923.x.pd
What does immunology have to do with brain development and neuropsychiatric disorders?
Introdução: O desenvolvimento neural Ă© um processo extremamente complexo e dinĂąmico. Tao pronto se inicia o desenvolvimento do cĂ©rebro, as "cĂ©lulas imunolĂłgicas" desempenham um papel fundamental em vĂĄrios processos, incluindo a formação e aperfeiçoamento de circuitos neurais, bem como a diferenciação sexual. HĂĄ um crescente corpo de evidĂȘncias de que o sistema imunolĂłgico tambĂ©m desempenha um papel importante na fidiopatologia de diversos transtornos neurodesenvolvimentais e neuropsiquiĂĄtricos. Objetivo: O objetivo deste artigo Ă© revisar os dados atualmente disponĂveis sobre o papel do "sistema imunolĂłgico" em relação ao desenvolvimento normal do cĂ©rebro, bem como a fisiopatogenia dos transtornos de neurodesenvolvimento e neuropsiquiĂĄtricos. Metodologia: Foi realizada uma pesquisa bibliogrĂĄfica tradicional para localizar artigos de revisĂŁo relevantes. Resultados: Os processos celulares e moleculares que compĂ”em o nosso "sistema imunolĂłgico" sĂŁo cruciais para o desenvolvimento normal do cĂ©rebro e a formação e manutenção de circuitos neurais. Ă cada vez mais evidente que o sistema imunolĂłgico e neuroinflamação desempenham papĂ©is importantes na etiopatogenia de pelo menos um subconjunto de indivĂduos com autismo, esquizofrenia, transtorno obsessivo-compulsivo, sĂndrome de Tourette, depressĂŁo e transtornos do humor, bem como distĂșrbios autoimunes e neurodegenerativos. EvidĂȘncias emergentes tambĂ©m apontam para a importĂąncia do eixo intestino-cerebral e do microbioma de um indivĂduo em relação Ă sua saĂșde e bem-estar somĂĄtico e mental. ConclusĂ”es: Existem interconexĂ”es multidirecionais entre mĂșltiplos sistemas biolĂłgicos em nossos cĂ©rebros e corpos que sĂŁo mediados em parte pelo sistema imunolĂłgico. No momento, no entanto, a "promessa" desse campo continua sendo maior do que os "resultados finais". O tempo dirĂĄ se novas intervençÔes serĂŁo desenvolvidas que farĂŁo uma diferença positiva no cuidado de nossos pacientes. TambĂ©m Ă© possĂvel que surjam biomarcadores vĂĄlidos que orientarĂŁo uma abordagem mais personalizada ao tratamento.Introduction: Neural development is an enormously complex and dynamic process. From very early in brain development âimmune cellsâ play a key role in a number of processes including the formation and refinement of neural circuits, as well as sexual differentiation. There is a growing body of evidence that the immune system also plays an important role in the pathobiology of several neurodevelopmental and neuropsychiatric disorders. Objective: The goal of this article is to review the currently available data concerning the role of the âimmune systemâ in normal brain development, as well as its role in the pathobiology of neurodevelopmental and neuropsychiatric disorders. Methodology: We conducted a traditional literature search using PubMed and recent special issues of journals to locate relevant review articles. Results: The cellular and molecular processes that make up our âimmune systemâ are crucial to normal brain development and the formation and maintenance of neural circuits. It is also increasingly evident that the immune system and neuroinflammation play important roles in the pathobiology of at least a subset of individuals with Autism Spectrum Disorder (ASD), schizophrenia, obsessive-compulsive disorder, Tourette syndrome and mood disorders, such as depression, as well as autoimmune and neurodegenerative disorders. Emerging evidence also points to the importance of the âgut-brain axisâ and an individualâs microbiome, which can impact an individualâs somatic and mental well-being. Conclusions: There are multidirectional interconnections across multiple biological systems in our brains and bodies that are mediated in part by the immune system. At present, however, the âpromiseâ of this field remains greater than the âdeliverables.â Time will tell whether novel interventions will be developed that will make a positive difference in the care of our patients. It is also possible that valid biomarkers will emerge that will guide a more personalized approach to treatment
A Multicenter Examination and Strategic Revisions of the Yale Global Tic Severity Scale
Objective To examine the internal consistency and distribution of the Yale Global Tic Severity Scale (YGTSS) scores to inform modification of the measure. Methods This cross-sectional study included 617 participants with a tic disorder (516 children and 101 adults), who completed an age-appropriate diagnostic interview and the YGTSS to evaluate tic symptom severity. The distributions of scores on YGTSS dimensions were evaluated for normality and skewness. For dimensions that were skewed across motor and phonic tics, a modified Delphi consensus process was used to revise selected anchor points. Results Children and adults had similar clinical characteristics, including tic symptom severity. All participants were examined together. Strong internal consistency was identified for the YGTSS Motor Tic score (α = 0.80), YGTSS Phonic Tic score (α = 0.87), and YGTSS Total Tic score (α = 0.82). The YGTSS Total Tic and Impairment scores exhibited relatively normal distributions. Several subscales and individual item scales departed from a normal distribution. Higher scores were more often used on the Motor Tic Number, Frequency, and Intensity dimensions and the Phonic Tic Frequency dimension. By contrast, lower scores were more often used on Motor Tic Complexity and Interference, and Phonic Tic Number, Intensity, Complexity, and Interference. Conclusions The YGTSS exhibits good internal consistency across children and adults. The parallel findings across Motor and Phonic Frequency, Complexity, and Interference dimensions prompted minor revisions to the anchor point description to promote use of the full range of scores in each dimension. Specific minor revisions to the YGTSS Phonic Tic Symptom Checklist were also proposed
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Animal studies suggest that structural changes occur in the maternal brain during the early postpartum period in regions such as the hypothalamus, amygdala, parietal lobe, and prefrontal cortex and such changes are related to the expression of maternal behaviors. In an attempt to explore this in humans, we conducted a prospective longitudinal study to examine gray matter changes using voxel-based morphometry on high resolution magnetic resonance images of mothers' brains at two time points: 2-4 weeks postpartum and 3-4 months postpartum. Comparing gray matter volumes across these two time points, we found increases in gray matter volume of the prefrontal cortex, parietal lobes, and midbrain areas. Increased gray matter volume in the midbrain including the hypothalamus, substantia nigra, and amygdala was associated with maternal positive perception of her baby. These results suggest that the first months of motherhood in humans are accompanied by structural changes in brain regions implicated in maternal motivation and behaviors
A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Objective: This study evaluated the efficacy of an Integrated Brain, Body, and Social (IBBS) intervention for children with ADHD. Treatment consisted of computerized cognitive remediation training, physical exercises, and a behavior management strategy.
Method: Ninety-two children aged 5 to 9 years with ADHD were randomly assigned to 15 weeks of IBBS or to treatment-as-usual. Primary outcome measures included blinded clinician ratings of ADHD symptoms and global clinical functioning. Secondary outcome measures consisted of parent and teacher ratings of ADHD and neurocognitive tests.
Results: No significant treatment effects were found on any of our primary outcome measures. In terms of secondary outcome measures, the IBBS group showed significant improvement on a verbal working memory task; however, this result did not survive correction for multiple group comparisons.
Conclusion: These results suggest that expanding cognitive training to multiple domains by means of two training modalities does not lead to generalized improvement of ADHD symptomatology
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Lessons Learned from Open-label Deep Brain Stimulation for Tourette Syndrome: Eight Cases over 7 Years
Background: Deep brain stimulation (DBS) remains an experimental but promising treatment for patients with severe refractory Gilles de la Tourette syndrome (TS). Controversial issues include the selection of patients (age and clinical presentation), the choice of brain targets to obtain optimal patient-specific outcomes, and the risk of surgery- and stimulation-related serious adverse events. Methods: This report describes our open-label experience with eight patients with severe refractory malignant TS treated with DBS. The electrodes were placed in the midline thalamic nuclei or globus pallidus, pars internus, or both. Tics were clinically assessed in all patients pre- and postoperatively using the Modified Rush Video Protocol and the Yale Global Tic Severity Scale (YGTSS). Results: Although three patients had marked postoperative improvement in their tics (>50% improvement on the YGTSS), the majority did not reach this level of clinical improvement. Two patients had to have their DBS leads removed (one because of postoperative infection and another because of lack of benefit). Discussion Our clinical experience supports the urgent need for more data and refinements in interventions and outcome measurements for severe, malignant, and medication-refractory TS. Because TS is not an etiologically homogenous clinical entity, the inclusion criteria for DBS patients and the choice of brain targets will require more refinement
Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
The Tourette Syndrome Association, IncThe Swedish Council for Working Life and Social ResearchThe Swedish Research CouncilManuscrip
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