12 research outputs found
Suivi dermatologique et tumeurs cutanées des greffés rénaux du CHU de Grenoble
Le but de notre travail a Ă©tĂ© d Ă©valuer le suivi dermatologique et les tumeurs cutanĂ©es prĂ©sentĂ©es par les patients qui ont reçu une greffe rĂ©nale au CHU de Grenoble et dont le greffon Ă©tait fonctionnel depuis plus d un an. Dans notre cohorte de 436 patients, l incidence des verrues et des kĂ©ratoses actiniques sont respectivement de 48,8% et 20,6%, et augmentent avec la durĂ©e d immunosuppression. L incidence des carcinomes cutanĂ©s est de 19,3%. Contrairement Ă la plupart des Ă©tudes de la littĂ©rature, notre population prĂ©sente plus de carcinomes basocellulaires (123 au total) que de carcinomes Ă©pidermoĂŻdes invasifs (49), et aucun cas de carcinome mĂ©tastatique n a Ă©tĂ© recensĂ© dans cette sĂ©rie. Les facteurs de risque des carcinomes cutanĂ©s confirment par contre ceux de la littĂ©rature : l Ăąge Ă©levĂ© lors de la greffe, la durĂ©e d immunosuppression, le phototype clair, la prĂ©sence de verrues et de kĂ©ratoses actiniques. Les lĂ©sions virales, ainsi que les lĂ©sions prĂ©cancĂ©reuses et les carcinomes sont localisĂ©es principalement sur les zones photoexposĂ©es, laissant supposer un rĂŽle important de l exposition solaire. Cependant cette prĂ©dominance sur les zones photoexposĂ©es est plus marquĂ©e pour les carcinomes Ă©pidermoĂŻdes que pour les carcinomes basocellulaires et les maladies de Bowen. MalgrĂ© l incidence Ă©levĂ©e des tumeurs cutanĂ©es dans notre sĂ©rie, il apparaĂźt que le suivi dermatologique est insuffisant puisque moins de deux tiers des patients ont consultĂ© un dermatologue depuis la greffe. L enseignement des rĂšgles de photoprotection et les contrĂŽles dermatologiques devraient donc ĂȘtre intensifiĂ©s.GRENOBLE1-BU MĂ©decine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Suicidal hanging resulting in decapitation: A case report and review of the literature.
International audienceDecapitation following suicidal hanging is rarely encountered in forensic practice. The authors report a case of suicidal hanging resulting in decapitation following a fall of 5m. This case is compared with 30 cases found in the literature. Several factors including type of rope, skin abrasion, level of the severed vertebrae, thyroid cartilage and hyoid bone injuries and vital signs are studied. The force applied to the neck and the kinetic energy were calculated. The kinetic energy (ranging from 1820 to 7310J) takes into account the weight of the victim but also the length of the rope (height of the fall). The speed of the body as it is stopped by the rope ranged between 6.49 and 14.01ms-1
Suicidal hanging resulting in decapitation: A case report and review of the literature.
International audienceDecapitation following suicidal hanging is rarely encountered in forensic practice. The authors report a case of suicidal hanging resulting in decapitation following a fall of 5m. This case is compared with 30 cases found in the literature. Several factors including type of rope, skin abrasion, level of the severed vertebrae, thyroid cartilage and hyoid bone injuries and vital signs are studied. The force applied to the neck and the kinetic energy were calculated. The kinetic energy (ranging from 1820 to 7310J) takes into account the weight of the victim but also the length of the rope (height of the fall). The speed of the body as it is stopped by the rope ranged between 6.49 and 14.01ms-1
Methodology for estimating endocranial capacity in a modern European population
International audienceVarious methods have been published in the literature to estimate endocranial capacity. These are based on mathematical equations using measurements made directly on the skull or indirectly from X-rays, by filling the skull with various materials, by endocasts both physical and virtual (using 3D CT-scan reconstructions). Each method has its advantages, limits and drawbacks. A useful method is one that is simple, time-efficient, cheap, and reproducible. For this study we estimated endocranial capacity by filling the skull with calibrated glass beads. We used a thorough protocol of tamping to ensure results reproducibility. Intra- and inter-observer trials showed no significant differences. The method was applied to 130 recent French (West European) skulls (65 males and 65 females). Sexual dimorphism was studied using logistic regression functions, discriminant analysis, and neural network. The best results were obtained using the neural network, built with two hidden nodes in the hidden layer and one output node, and trained with a steepest descent algorithm. Our tests show that there is obvious sexual dimorphism (p < 10(-5)) of the weight of the skulls (623.44 ± 106.83 g in males; 548.07 ± 94.57 in females), the weight of the glass beads used to fill the skulls (2379.83 ± 228.92 g in males; 2095.95 ± 145.49 in females), and endocranial capacity (1676.47 cm(3) ± 161.26 in males; 1476.48 ± 102.49 in females), but overlapping between sexes is quite significant. The average ECC in male (1676.5 cm(3)) and in female (1476.5 cm(3)) subjects is higher than those previously published, which deserves some discussion
Methodology for estimating endocranial capacity in a modern European population
International audienceVarious methods have been published in the literature to estimate endocranial capacity. These are based on mathematical equations using measurements made directly on the skull or indirectly from X-rays, by filling the skull with various materials, by endocasts both physical and virtual (using 3D CT-scan reconstructions). Each method has its advantages, limits and drawbacks. A useful method is one that is simple, time-efficient, cheap, and reproducible. For this study we estimated endocranial capacity by filling the skull with calibrated glass beads. We used a thorough protocol of tamping to ensure results reproducibility. Intra- and inter-observer trials showed no significant differences. The method was applied to 130 recent French (West European) skulls (65 males and 65 females). Sexual dimorphism was studied using logistic regression functions, discriminant analysis, and neural network. The best results were obtained using the neural network, built with two hidden nodes in the hidden layer and one output node, and trained with a steepest descent algorithm. Our tests show that there is obvious sexual dimorphism (p < 10(-5)) of the weight of the skulls (623.44 ± 106.83 g in males; 548.07 ± 94.57 in females), the weight of the glass beads used to fill the skulls (2379.83 ± 228.92 g in males; 2095.95 ± 145.49 in females), and endocranial capacity (1676.47 cm(3) ± 161.26 in males; 1476.48 ± 102.49 in females), but overlapping between sexes is quite significant. The average ECC in male (1676.5 cm(3)) and in female (1476.5 cm(3)) subjects is higher than those previously published, which deserves some discussion
Etude de phase II de lâadministration de Pembrolizumab en monothĂ©rapie et en premiĂšre ligne chez des patients prĂ©sentant un carcinome Ă©pidermoĂŻde cutanĂ© inopĂ©rable.
International audienc
Pembrolizumab as first line therapy in patients with unresectable squamous cell carcinoma of the skin: Interim results of the phase 2 CARSKIN trial.
International audienc
Pembrolizumab as first line therapy in patients with unresectable squamous cell carcinoma of the skin: Interim results of the phase 2 CARSKIN trial.
Phase II Study of Pembrolizumab As First-Line, Single-Drug Therapy for Patients With Unresectable Cutaneous Squamous Cell Carcinomas
International audiencePURPOSE To evaluate first-line pembrolizumab monotherapy efficacy and safety in patients with unresectable cutaneous squamous cell carcinomas (CSCCs). PATIENTS AND METHODS Patients, predominantly men, with their CSSCsâ immunohistochemically determined programmed cell death-ligand 1 (PD-L1) status determined (tumor proportion score threshold, 1%), received pembrolizumab (200 mg every 3 weeks). The primary endpoint was the 39-patient primary cohortâs objective response rate at week 15 (ORR W15 ). Secondary objectives were best ORR, overall survival (OS), progression-free survival (PFS), duration of response (DOR), safety, ORR according to PD-L1 status and health-related quality of life using Functional Assessment of Cancer TherapyâGeneral (FACT-G) score. An 18-patient expansion cohort, recruited to power the study to evaluate the ORR W15 difference between PD-L1+ and PD-L1â patients, was assessed for ORR, disease control rate, and safety, but not survival. RESULTS Median age of all patients was 79 years. The primary cohortâs ORR W15 was 41% (95% CI, 26% to 58%), including 13 partial and 3 complete responses. Best responses were 8 partial and 8 complete responses. At a median follow-up of 22.4 months, respective median PFS, DOR, and OS were 6.7 months, not reached, and 25.3 months, respectively. Pembrolizumab-related adverse events affected 71% of the patients, and 4 (7%) were grade â„ 3. One death was related to rapid CSCC progression; another resulted from a fatal second aggressive head and neck squamous cell carcinoma diagnosed 15 weeks postinclusion. ORR W15 for the entire population was 42%; it was significantly higher for PD-L1+ patients (55%) versus PD-L1â patients (17%; P = .02). Respondersâ W15 total FACT-G score had improved ( P = .025) compared with nonresponders. CONCLUSION First-line pembrolizumab monotherapy exhibited promising anti-CSCC activity, with durable responses and manageable safety. PD-L1 positivity appears to be predictive of pembrolizumab efficacy