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International audienceThe GANIL facility consists of three successive cyclotrons. The tuning of these cyclotrons and of the transfer beam lines isachieved in about 24 hours. Reducing this setting time would enable to increase the time allocated to physics experiments.New tools are realized for automatic beam tuning. These tools are expected to make the tuning easier, shorter and morereproducible

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International audienceThe GANIL facility consists of three successive cyclotrons. The tuning of these cyclotrons and of the transfer beam lines isachieved in about 24 hours. Reducing this setting time would enable to increase the time allocated to physics experiments.New tools are realized for automatic beam tuning. These tools are expected to make the tuning easier, shorter and morereproducible

MONOBOB II : Latest results of monocharged ions source for SPIRAL2 project

Original publication available at http://www.jacow.orgInternational audienceAmong the sources which can be installed in the radioactive ion production module of SPIRAL II, a singly-charged ECRIS has been chosen to produce ions from gaseous elements. Its characterization is under way on a test bench at GANIL. Extraction, transport and response time results are presented

Permanent magnets under irradiation and radiocative alkali ion beam development for SPIRAL1

International audienceUp to now, eighteen Target Ion Source Systems (TISSs) have been built and used for the production of radioactive ion beams on SPIRAL 1 facility, based on the Isotope- Separator-On-Line (ISOL) method. The TISSs are composed of thick carbon targets and of fully permanentmagnet Electron Cyclotron Resonance Ion Sources (ECRISs) of the Nanogan III type. After irradiation and a decay period of two years, the irradiated TISSs are dismounted and if their magnetic fields are still suitable, the ECRIS are used with a new target. Thereby thirty-two runs have been performed using new or renewed TISSs. , After irradiation, the measured magnetic field sometimes reveals magnet damage. Our experience is reported here. In the second section, we present the progress on the NanoNaKE setup, which aims to extend the radioactive ion beams in SPIRAL 1 to the alkali elements, by connecting a surface-ionization source to the Nanogan III ECRIS via a compact 1+ ion beam line. The main issues and difficulties are discussed and the preliminary solutions are described

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3 ubiquitin ligase HUWE1 as a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors. Furthermore, we show that mitophagy function of AMBRA1 is post-translationally controlled, upon HUWE1 activity, by a positive phosphorylation on its serine 1014. This modification is mediated by the IKKα kinase and induces structural changes in AMBRA1, thus promoting its interaction with LC3/GABARAP (mATG8) proteins and its mitophagic activity. Altogether, these results demonstrate that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells

Treatment Efficacy, Clinical Utility, and Cost-Effectiveness of Multidisciplinary Biopsychosocial Rehabilitation Treatments for Persistent Low Back Pain: A Systematic Review

Study Design: Systematic review. Objectives: To review the current literature on the treatment efficacy, clinical utility, and cost-effectiveness of multidisciplinary biopsychosocial rehabilitation (MBR) for patients suffering from persistent (nonspecific) lower back pain (LBP) in relation to pain intensity, disability, health-related quality of life, and work ability/sick leave. Methods: We carried out a systematic search of Web of Science, Cochrane Library, PubMed Central, EMBASE, and PsycINFO for English- and German-language literature published between January 2010 and July 2017. Study selection consisted of exclusion and inclusion phases. After screening for duplication, studies were excluded on the basis of criteria covering study design, number of participants, language of publication, and provision of information about the intervention. All the remaining articles dealing with the efficacy, utility, or cost-effectiveness of intensive (more than 25 hours per week) MBR encompassing at least 3 health domains and cognitive behavioral therapy–based psychological education were included. Results: The search retrieved 1199 publications of which 1116 were duplicates or met the exclusion criteria. Seventy of the remaining 83 articles did not meet the inclusion criteria; thus 13 studies were reviewed. All studies reporting changes in pain intensity or disability over 12 months after MBR reported moderate effect sizes and/or p-values for both outcomes. The effects on health-related quality of life were mixed, but MBR substantially reduced costs. Overall MBR produced an enduring improvement in work ability despite controversy and variable results. Conclusions: MBR is an effective treatment for nonspecific LBP, but there is room for improvement in cost-effectiveness and impact on sick leave, where the evidence was less compelling