Nonlinear Dimension Reduction for Microarray Data

[Biomedical imaging

What role in surgery for Raman spectroscopy?

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Creating Open-Source software packages for Raman spectrum processing and analysis

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Superstars and Giant Gravitons in M-theory

Following hep-th/0109127, we show that a certain class of BPS naked singularities (superstars) found in compactifications of M-theory can be interpreted as being composed of giant gravitons. More specifically, we study superstars which are asymptotically AdS_7 x S^4 and AdS_4 x S^7 and show that these field configurations can be interpreted as being sourced by continuous distributions of spherical M2- and M5-branes, respectively, which carry internal momenta and have expanded on the spherical component of the space-time.Comment: 13 page

Quantitative spectral quality assessment technique validated using intraoperative in vivo Raman spectroscopy measurements

Significance: Ensuring spectral quality is prerequisite to Raman spectroscopy applied to surgery. This is because the inclusion of poor-quality spectra in the training phase of Raman-based pathology detection models can compromise prediction robustness and generalizability to new data. Currently, there exists no quantitative spectral quality assessment technique that can be used to either reject low-quality data points in existing Raman datasets based on spectral morphology or, perhaps more importantly, to optimize the in vivo data acquisition process to ensure minimal spectral quality standards are met. Aim: To develop a quantitative method evaluating Raman signal quality based on the variance associated with stochastic noise in important tissue bands, including C─C stretch, CH2  /  CH3 deformation, and the amide bands. Approach: A single-point hand-held Raman spectroscopy probe system was used to acquire 315 spectra from 44 brain cancer patients. All measurements were classified as either high or low quality based on visual assessment (qualitative) and using a quantitative quality factor (QF) metric. Receiver-operator-characteristic (ROC) analyses were performed to evaluate the performance of the quantitative metric to assess spectral quality and improve cancer detection accuracy. Results: The method can separate high- and low-quality spectra with a sensitivity of 89% and a specificity of 90% which is shown to increase cancer detection sensitivity and specificity by up to 20% and 12%, respectively. Conclusions: The QF threshold is effective in stratifying spectra in terms of spectral quality and the observed false negatives and false positives can be linked to limitations of qualitative spectral quality assessment

Wide-field optical spectroscopy system integrating reflectance and spatial frequency domain imaging to measure attenuation-corrected intrinsic tissue fluorescence in radical prostatectomy specimens

The development of a multimodal optical imaging system is presented that integrates endogenous fluorescence and diffuse reflectance spectroscopy with single-wavelength spatial frequency domain imaging (SFDI) and surface profilometry. The system images specimens at visible wavelengths with a spatial resolution of 70 microm, a field of view of 25 cm(2) and a depth of field of approximately 1.5 cm. The results of phantom experiments are presented demonstrating the system retrieves absorption and reduced scattering coefficient maps using SFDI with <6% reconstruction errors. A phase-shifting profilometry technique is implemented and the resulting 3-D surface used to compute a geometric correction ensuring optical properties reconstruction errors are maintained to <6% in curved media with height variations <20 mm. Combining SFDI-computed optical properties with data from diffuse reflectance spectra is shown to correct fluorescence using a model based on light transport in tissue theory. The system is used to image a human prostate, demonstrating its ability to distinguish prostatic tissue (anterior stroma, hyperplasia, peripheral zone) from extra-prostatic tissue (urethra, ejaculatory ducts, peri-prostatic tissue). These techniques could be integrated in robotic-assisted surgical systems to enhance information provided to surgeons and improve procedural accuracy by minimizing the risk of damage to extra-prostatic tissue during radical prostatectomy procedures and eventually detect residual cancer

Tall tales from de Sitter space II: Field theory dualities

We consider the evolution of massive scalar fields in (asymptotically) de Sitter spacetimes of arbitrary dimension. Through the proposed dS/CFT correspondence, our analysis points to the existence of new nonlocal dualities for the Euclidean conformal field theory. A massless conformally coupled scalar field provides an example where the analysis is easily explicitly extended to 'tall' background spacetimes.Comment: 31 pages, 2 figure

Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia

International audienceHairy cell leukaemia (HCL) is a rare haematological malignancy, with approximately 175 new incident cases in France. Diagnosis is based on a careful examination of the blood smear and immunophenotyping of the tumour cells, with a panel of four markers being used specifically to screen for hairy cells (CD11c, CD25, CD103 and CD123). In 2011, the V600E mutation of the BRAF gene in exon 15 was identified in HCL; being present in HCL, it is absent in the variant form of HCL (HCL-v) and in splenic red pulp lymphoma (SRPL), two entities related to HCL. The management of patients with HCL has changed in recent years. A poorer response to purine nucleoside analogues (PNAs) is observed in patients with more marked leukocytosis, bulky splenomegaly, an unmutated immunoglobulin variable heavy chain (IgVH) gene profile, use of VH4-34 or with TP53 mutations. We present the recommendations of a group of 11 experts belonging to a number of French hospitals. This group met in November 2013 to examine the criteria for managing patients with HCL. The ideas and proposals of the group are based on a critical analysis of the recommendations already published in the literature and on an analysis of the practices of clinical haematology departments with experience in managing these patients. The first-line treatment uses purine analogues: cladribine or pentostatin. The role of BRAF inhibitors, whether or not combined with MEK inhibitors, is discussed. The panel of French experts proposed recommendations to manage patients with HCL, which can be used in a daily practice

SD-brane gravity fields and rolling tachyons

S(pacelike)D-branes are objects arising naturally in string theory when Dirichlet boundary conditions are imposed on the time direction. SD-brane physics is inherently time-dependent. Previous investigations of gravity fields of SD-branes have yielded undesirable naked spacelike singularities. We set up the problem of coupling the most relevant open-string tachyonic mode to massless closed-string modes in the bulk, with backreaction and Ramond-Ramond fields included. We find solutions numerically in a self-consistent approximation; our solutions are naturally asymptotically flat and time-reversal asymmetric. We find completely nonsingular evolution; in particular, the dilaton and curvature are well-behaved for all time. The essential mechanism for spacetime singularity resolution is the inclusion of full backreaction between the bulk fields and the rolling tachyon. Our analysis is not the final word on the story, because we have to make some significant approximations, most notably homogeneity of the tachyon on the unstable branes. Nonetheless, we provide significant progress in plugging a gaping hole in prior understanding of the gravity fields of SD-branes.Comment: References added. Analysis for much broader range of solutions presented. Conclusions unchanged. Time-reversal symmetric examples ruled out, new examples are provide