Çocukluk çağı akut lösemileri kemik iliği blastik hücrelerinde vasküler endotelyal büyüme faktörü mrna düzeyi

TEZ4711Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2003.Kaynakça (s. 56-49) var.vii, 59 s. ; 30 cm.

Çocukluk çağı akut lösemilerinde flt3 (fms-like tyrosine kinase 3) mutasyonları

TEZ7022Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2008.Kaynakça (s.50-60) var.viii, 61 s. : res. ; 29 cm.Purpose: In this study it is aimed to investigate the presence of mutations of FLT3 receptor which is related with cellular surveillance, differentiation and proliferation pathways, and whether its presence affects prognosis and other clinical parameters in childhood leukemias. Matherial and Methods: Fifty three patients diagnosed as ALL and sixteen patients diagnosed as AML by cytomorphological, immuno histochemical and immuno flow-cytometric methods were included in this study. Results: FLT3/TKD mutation distribution in ALL and AML groups is as follows; only one patient in ALL group and 4 patients in AML group were detected. In ALL group the patient having mutation is 8 years old boy, in pre-B group ALL-L1, alive and also in remission. In the patients with mutation of AML group: one have relapsed disease and totally 3 of them deceased including relapsed patient, but there is no difference of mortality or morbidity between FLT3/TKD mutation carrying and others in AML patients statistically (p>0.05).Amac: Bu calısmada cocukluk cağı akut losemilerinde hucre yasamı, farklanma ve coğalması ile ilgili yollarla bağlantılı bir reseptor olan FLT3'un (FMS-Like Tyrosin Kinase) mutasyonlarının losemi hastalarında varlığı ve bu mutasyonların prognoz ve diğer klinik tablo ile iliskilerinin arastırılması planlandı. Materyal Metod: Calısmaya sitomorfolojik, immunohistokimyasal ve immun akımsitometrik metodlar ile ALL tanısı alan 53 hasta ile AML tanısı alan 16 cocuk hasta dahil edildi. Bulgular: ALL ve AML tanılı hasta gruplarında saptanan FLT3/TKD mutasyon dağılımı; ALL grubunda 1 hasta (% 2) ve AML grubunda 4 hasta (% 25) seklindeydi. Mutasyon saptanan ALL hastası 8 yasında erkek hasta FAB sınıflamasına gore ALL-L1 idi. mmunfenotipleme ile pre-B grubunda olan hasta risk grubu olarak SRG'ye dahil olmustu. Hasta halen hayatta ve remisyondaydı. AML grubunda FLT3/TKD mutasyonu tasıyan hastalar icinde bir hasta relaps olmustu, ancak relaps olan hasta ile birlikte 4 hastadan ucu kaybedilmisti. Buna rağmen yapılan istatistiksel incelemelerle mutasyon tasıyan AML hastaları ile tasımayan hastalar arasında mortalite ve morbidite acısından anlamlı bir fark saptanamadı (p>0,05).Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No

Congenital pseudohorseshoe lung associated with scimitar syndrome

WOS: 000314702600008PubMed: 23329972Horseshoe lung is a congenital pulmonary malformation that is usually associated with scimitar syndrome. This malformation consists of fusion of both pulmonary lobes from the posterobasal segments. The fusion appears in the retrocardiac area, in front of the esophagus and thoracic aorta. Pleural separation of pulmonary lobes distinguishes pseudohorseshoe appearance from a true horseshoe lung. Scimitar syndrome known as hypogenetic lung syndrome is a part of the congenital pulmonary venolobar syndrome. It is a partial anomalous pulmonary venous return with pulmonary hypoplasia. Scimitar vein is an anomalous drainage vessel between the right pulmonary lobe vessels and the inferior vena cava. The appearance of the vessel resembles Turkish scimitar; therefore, the syndrome is called scimitar syndrome. We hereby report a 61-year-old woman with adult form congenital scimitar syndrome and will describe the imaging findings of pseudohorseshoe lung appearance. Copyright (C) 2012, Tehran University of Medical Sciences and Iranian Society of Radiology. Published by Kowsar Corp. All rights reserved

Differentiation between neoplastic and nonneoplastic brain masses using intermediate echo time MR Spectroscopy

AbstractAim: The aim of this study was to evaluate the role of intermediate echo time (TE) Proton Magnetic Resonance Spectroscopy (1 H-MRS)  in the differential diagnosis of neoplastic and nonneoplastic cerebral mass lesions.Materials and Methods: The research was done at Cukurova University in a 1.5 Tesla whole-body MR system. In point-resolved-single volume-spectroscopy (PRESS) localization method, Probe-P pulse sequence was studied with intermediate TE (TE=144). Of 55 cases whose diagnosis was confirmed with the histopathologically or clinical and radiological follow-up,  MR Spectroscopy findings were discussed.Results: Twenty cases’ definite diagnosis were neoplastic and thirty-five cases’ were nonneoplastic lesions. For tumor detection in cerebral mass lesions, intermediate TE MRS  was determined 100% sensitive and 91.7% specific.  The positive predictive value was 86.4% and the negative one was 100%. In this study, in the neoplastic-nonneoplastic lesion differential diagnosis, NAA/Cho, NAA/Cr, Cho/Cr, and Cho/NAA ratios were evaluated and the most useful of them were found to be Cho/NAA ratio. Conclusion: It is concluded that intermediate TE MR Spectroscopy is a reliable imaging technique for the neoplastic-nonneoplastic differential diagnosis of the cerebral mass lesions

Neurological Complications in Child with Chronic Renal Failure

Congenital uremic encephalopathy, progressive dialysis encephalopathy, Wernicke encefalopathy, headache, seizures because of dialysis, disequilibrium syndrome, cerebral hemorrhage and uremic neuropathy are the neurologic complications seen in child with chronic renal failure. Here it is aimed to discuss these complications with literature, and to emphasize the importance of evaluation of patients with these aspects. [Archives Medical Review Journal 2003; 12(4.000): 406-412

Gluten-Related Methemoglobinemia

PubMedID: 26348306[No abstract available

Insulin Like Growth Factor (IGF) [İnsülin benzeri büyüme faktörü (IGF)]

Insulin Like Growth Hormone (IGF) is a peptide family, depends on and suplying most of the anabolic and mitogenic effects of growth hormon (GH). Beside its GH dependance of serum consantration, showing its effects in tissues other than skeletal ones, increasing the binding of sulphate to the cartilage, stimulating the DNA synthesis and cell proliferation it has also some other duties. IGF-1 is a sample peptide of 70 aminoacids also celled SM-C. IGF-2 is an acidic peptide composed of 67 aminoacids. In both peptides 45 of the 73 aminoacid position are same and almost % 50 aminoacid of them also same with insulin. Both IGF consists of A and D chains binding with disulphide bindings like insulin. We present this review so as to evaluate the findings of the studies made in recent years about Insulin Like Growth Factor

Pseudotumor cerebri, after the withdrowal of steroid treatment

Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen.Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen

Mobile kidney [Mobil böbrek]

Mobile, floating or wandering kidney, or medial nephroptosis has been defined as descensus and migration of kidney medially or anteriorly towards abdominal wall. Diagnosis of mobile kidney has mainly been done with clinical examination and intravenous urography in the supine and upright positions. In this study, a woman diagnosed as mobile kidney with symptoms is presented with the findings of clinical examination, intravenous urography, ultrasonography and computed tomography