Direct costs and cost-effectiveness of dual-source computed tomography and invasive coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease

The study aims to determine the direct costs and comparative cost-effectiveness of latest-generation dual-source computed tomography (DSCT) and invasive coronary angiography for diagnosing coronary artery disease (CAD) in patients suspected of having this disease

Recurrent \u3cem\u3eStreptococcus equi\u3c/em\u3e subsp. \u3cem\u3ezooepidemicus\u3c/em\u3e Bacteremia in an Infant

We describe a case of an infant with recurrent bacteremia caused by Streptococcus equi subsp. zooepidemicus, likely transmitted from mother to infant. Our case highlights the importance of an epidemiological history and molecular diagnostics in ascertaining insights into transmission, pathogenesis, and optimal management

Microstructure of near-infrared pulsed laser sintered titanium samples

The microstructure and material properties of near-infrared pulsed laser sintered titanium have been investigated. Several analyses of the selectively laser sintered titanium powder, using characterisation techniques such as compressive strength, microhardness, energy-dispersive X-ray microanalysis, X-ray diffractometry and scanning electron microscopy analysis, allowed the metallurgical description of the sintering process. Only partial melting in a narrow surface layer took place, whereas most of the material stayed clearly below the melting temperatur

Stable individual differences in strategies within, but not between, visual search tasks

A striking range of individual differences has recently been reported in three different visual search tasks. These differences in performance can be attributed to strategy, that is, the efficiency with which participants control their search to complete the task quickly and accurately. Here we ask if an individual's strategy and performance in one search task is correlated with how they perform in the other two. We tested 64 observers in the three tasks mentioned above over two sessions. Even though the test-retest reliability of the tasks is high, an observer's performance and strategy in one task did not reliably predict their behaviour in the other two. These results suggest search strategies are stable over time, but context-specific. To understand visual search we therefore need to account not only for differences between individuals, but also how individuals interact with the search task and context. These context-specific but stable individual differences in strategy can account for a substantial proportion of variability in search performance

Monotherapy Trials of New Antiepileptic Drugs

A number of clinical trials that test the efficacy and safety of the newer antiepileptic drugs (AEDs) have recently been concluded. Two dose-response trials in inpatients with refractory partial seizures and outpatients with newly diagnosed partial epilepsy established the efficacy of gabapentin as monotherapy. Lamotrigine was found to have efficacy similar to that of phenytoin and carbamazepine (CBZ) and to be better tolerated than CBZ in patients with newly diagnosed epilepsy. It was also shown to have efficacy as monotherapy in partial seizures, based on the results of an active controlled trial, and in the treatment of absence seizures, based on the results of a responder-enriched study. Topiramate as monotherapy was found to be efficacious for treatment of partial-onset seizures, based on the results of a single-center dose-response trial. A dose-response trial that tested the efficacy of tiagabine monotherapy in patients with refractory partial epilepsy was uninformative. Oxcarbazepine was found to be safe and efficacious in four comparative trials in patients with newly diagnosed epilepsy as well as in one placebo-controlled inpatient trial in patients with refractory partial seizures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65625/1/j.1528-1157.1997.tb05201.x.pd

Postexposure Treatment and Animal Rabies, Ontario, 1958-2000

This paper investigates the relationship between animal rabies and postexposure treatment (PET) in Ontario by examining the introduction of human diploid cell vaccine (HDCV) in 1980 and the initiation of an oral rabies vaccination program for wildlife in 1989. Introducing HDCV led to an immediate doubling of treatments. Both animal rabies and human treatments declined rapidly after the vaccination program was introduced, but human treatments have leveled off at approximately 1,000 per year