Detection of Gravitational Waves from the Coalescence of Population-III Remnants with Advanced LIGO

The comoving mass density of massive black hole (MBH) remnants from pre-galactic star formation could have been similar in magnitude to the mass-density of supermassive black holes (SMBHs) in the present-day universe. We show that the fraction of MBHs that coalesce during the assembly of SMBHs can be extracted from the rate of ring-down gravitational waves that are detectable by Advanced LIGO. Based on the SMBH formation history inferred from the evolution of the quasar luminosity function, we show that an observed event rate of 1 per year will constrain the SMBH mass fraction that was contributed by MBHs coalescence down to a level of ~10^-6 for 20 solar mass MBH remnants (or ~10^-4 for 260 solar mass remnants).Comment: 4 pages, 2 figures. Submitted to ApJ Letter

Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs

Background aims Multipotent mesenchymal stromal cells (MSCs) are distinguished by their ability to differentiate into a number of stromal derivatives of interest for regenerative medicine, but they also have immunoregulatory properties that are being tested in a number of clinical settings. Methods We show that brief incubations with rapamycin, everolimus, FK506 or cyclosporine A increase the immunosuppressive potency of MSCs and other cell types. Results The treated MSCs are up to 5-fold more potent at inhibiting the induced proliferation of T lymphocytes in vitro. We show that this effect probably is due to adsorption of the drug by the MSCs during pre-treatment, with subsequent diffusion into co-cultures at concentrations sufficient to inhibit T-cell proliferation. MSCs contain measurable amounts of rapamycin after a 15-min exposure, and the potentiating effect is blocked by a neutralizing antibody to the drug. With the use of a pre-clinical model of acute graft-versus-host disease, we demonstrate that a low dose of rapamycin-treated but not untreated umbilical cord–derived MSCs significantly inhibit the onset of disease. Conclusions The use of treated MSCs may achieve clinical end points not reached with untreated MSCs and allow for infusion of fewer cells to reduce costs and minimize potential side effects

Influence of Giving a Choice of Grazing or Maize Silage Offered in the Field Simultaneously on Diet Selection of Lactating Dairy Cows

Changing the times of access to grazing and to maize silage (MS) offered indoors affects the relative intake of each feed, but has little effect on dairy cow performance (Hernandez-Mendo & Leaver, 2000). Offering the MS in the grazing paddock as an instantaneous alternative to grazing should give an insight into the factors influencing feed intake, and may provide a means of alleviating the high rate of decline in milk yield of grazing dairy cows. The objective of this study was to examine the response in diet preferences and performance of lactating dairy cows when grazing a perennial ryegrass sward and having access to maize silage ad libitum simultaneously in spring, at two concentrate levels (CL) and two sward heights (SH)

Dirac Quasinormal modes of Schwarzschild black hole

The quasinormal modes (QNMs) associated with the decay of Dirac field perturbation around a Schwarzschild black hole is investigated by using continued fraction and Hill-determinant approaches. It is shown that the fundamental quasinormal frequencies become evenly spaced for large angular quantum number and the spacing is given by $\omega_{\lambda+1}- \omega_{\lambda}=0.38490-0.00000i$. The angular quantum number has the surprising effect of increasing real part of the quasinormal frequencies, but it almost does not affect imaginary part, especially for low overtones. In addition, the quasinormal frequencies also become evenly spaced for large overtone number and the spacing for imaginary part is $Im(\omega_{n+1})-Im(\omega_n)\approx -i/4M$ which is same as that of the scalar, electromagnetic, and gravitational perturbations.Comment: 14 pages, 5 figure

The size, concentration, and growth of biodiversity-conservation nonprofits

Nonprofit organizations play a critical role in efforts to conserve biodiversity. Their success in this regard will be determined in part by how effectively individual nonprofits and the sector as a whole are structured. One of the most fundamental questions about an organization’s structure is how large it should be, with the logical counterpart being how concentrated the whole sector should be. We review empirical patterns in the size, concentration, and growth of over 1700 biodiversity-conservation nonprofits registered for tax purposes in the United States within the context of relevant economic theory. Conservation-nonprofit sizes vary by six to seven orders of magnitude and are positively skewed. Larger nonprofits access more revenue streams and hold more of their assets in land and buildings than smaller or midsized nonprofits do. The size of conservation nonprofits varies with the ecological focus of the organization, but the growth rates of nonprofits do not

Massive scalar field quasi-normal modes of higher dimensional black holes

We study quasinormal spectrum of massive scalar field in the $D$-dimensional black hole background. We found the qualitatively different dependence on the field mass of the fundamental modes for $D\geq6$. The behaviour of higher modes is qualitatively the same for all $D$. Thus for some particular values of mass (of the field and of the black hole) the spectrum has two dominating oscillations with a very long lifetime. Also we show that the asymptotically high overtones do not depend on the field mass. In addition, we present the generalisation of the Nollert improvement of the continued fraction technique for the numerical calculation of quasi-normal frequencies of $D$-dimensional black holes.Comment: 8 pages, 4 figures, misprints corrected, version to appear in Phys. Rev.

The management of common recurrent headaches by chiropractors: A descriptive analysis of a nationally representative survey

© 2018 The Author(s). Background: Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence of headache patients found within routine chiropractic practice and to assess how chiropractors approach key aspects of headache management applicable to primary care settings. Methods: A 31-item cross-sectional survey was distributed to a national sample of chiropractors (n = 1050) to report on practitioner approach to headache diagnosis, interdisciplinary collaboration, treatment and outcome assessment of headache patients who present with recurrent headache disorders. Results: The survey attracted a response rate of 36% (n = 381). One in five new patients present to chiropractors with a chief complaint of headache. The majority of chiropractors provide headache diagnosis for common primary (84.6%) and secondary (90.4%) headaches using formal headache classification criteria. Interdisciplinary referral for headache management was most often with CAM providers followed by GPs. Advice on headache triggers, stress management, spinal manipulation, soft tissue therapies and prescriptive neck exercises were the most common therapeutic approaches to headache management. Conclusion: Headache patients make up a substantial proportion of chiropractic caseload. The majority of chiropractors managing headache engage in headache diagnosis and interdisciplinary patient management. More research information is needed to understand the headache types and level of headache chronicity and disability common to chiropractic patient populations to further assess the healthcare needs of this patient population

Quasi-Normal Modes of Brane-Localised Standard Model Fields II: Kerr Black Holes

This paper presents a comprehensive study of the fundamental quasinormal modes of all Standard Model fields propagating on a brane embedded in a higher-dimensional rotating black hole spacetime. The equations of motion for fields with spin $s=0, 1/2$ and 1 propagating in the induced-on-the-brane background are solved numerically, and the dependence of their QN spectra on the black hole angular momentum and dimensionality of spacetime is investigated. It is found that the brane-localised field perturbations are longer-lived when the higher-dimensional black hole rotates faster, while an increase in the number of transverse-to-the-brane dimensions reduces their lifetime. Finally, the quality factor $Q$, that determines the best oscillator among the different field perturbations, is investigated and found to depend on properties of both the particular field studied (spin, multipole numbers) and the gravitational background (dimensionality, black hole angular momentum number).Comment: 12 pages, 8 figures, typos corrected, version to appear in Phys. Rev.

Numerical evolutions of a black hole-neutron star system in full General Relativity: I. Head-on collision

We present the first simulations in full General Relativity of the head-on collision between a neutron star and a black hole of comparable mass. These simulations are performed through the solution of the Einstein equations combined with an accurate solution of the relativistic hydrodynamics equations via high-resolution shock-capturing techniques. The initial data is obtained by following the York-Lichnerowicz conformal decomposition with the assumption of time symmetry. Unlike other relativistic studies of such systems, no limitation is set for the mass ratio between the black hole and the neutron star, nor on the position of the black hole, whose apparent horizon is entirely contained within the computational domain. The latter extends over ~400M and is covered with six levels of fixed mesh refinement. Concentrating on a prototypical binary system with mass ratio ~6, we find that although a tidal deformation is evident the neutron star is accreted promptly and entirely into the black hole. While the collision is completed before ~300M, the evolution is carried over up to ~1700M, thus providing time for the extraction of the gravitational-wave signal produced and allowing for a first estimate of the radiative efficiency of processes of this type.Comment: 16 pages, 12 figure