Effect of Diet on the Growth and Survival of Adrenalectomized Rats Treated with Corticosterone

Author Institution: Department of Anatomy, Medical College of Ohio at Toledo ; Bureau of Biological Research, Rutgers UniversityDietary protein content did not influence the life sustaining capacity of a daily 300 vg dose of corticosterone in adrenalectomized rats. A lower daily dosage of 150 ng was less effective when animals were fed a 5% casein diet. Depletion of body protein stores prior to adrenalectomy did not significantly alter the response pattern of animals maintained on a daily 300 fxg dose of corticosterone. Reducing the dietary protein content from 20% to 10% interfered with the capacity of the daily 150 /Jig dosage of corticosterone to support body weight gain in adrenalectomized rats. No significant changes in bod}^ weight were noted in adrenalectomized animals fed a 5% casein diet. Protein depletion had a favorable effect on this aspect of the hormone's activity when adrenalectomized rats were treated with the daily 300 ,ug dosage and refed 10% or 20% casein diets. Adrenalectomized animals maintained under these experimental conditions gained more weight than nondepleted animals fed the same diets

Managing hyperemesis gravidarum: a multimodal challenge

Up to 90% of pregnant women experience nausea and vomiting. When prolonged or severe, this is known as hyperemesis gravidarum (HG), which can, in individual cases, be life threatening. In this article the aetiology, diagnosis and treatment strategies will be presented based on a selective literature review. Treatment strategies range from outpatient dietary advice and antiemetic drugs to hospitalization and intravenous (IV) fluid replacement in persistent or severe cases. Alternative methods, such as acupuncture, are not yet evidence based but sometimes have a therapeutic effect