923 research outputs found
Hypervelocity Impact Performance of Open Cell Foam Core Sandwich Panel Structures
Open cell metallic foam core sandwich panel structures are of interest for application in spacecraft micrometeoroid and orbital debris shields due to their novel form and advantageous structural and thermal performance. Repeated shocking as a result of secondary impacts upon individual foam ligaments during the penetration process acts to raise the thermal state of impacting projectiles ; resulting in fragmentation, melting, and vaporization at lower velocities than with traditional shielding configurations (e.g. Whipple shield). In order to characterize the protective capability of these structures, an extensive experimental campaign was performed by the Johnson Space Center Hypervelocity Impact Technology Facility, the results of which are reported in this paper. Although not capable of competing against the protection levels achievable with leading heavy shields in use on modern high-risk vehicles (i.e. International Space Station modules), metallic foam core sandwich panels are shown to provide a substantial improvement over comparable structural panels and traditional low weight shielding alternatives such as honeycomb sandwich panels and metallic Whipple shields. A ballistic limit equation, generalized in terms of panel geometry, is derived and presented in a form suitable for application in risk assessment codes
Profiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis
In this study we profile free 3-oxo sterols present in plasma from patients affected with the neurodegenerative disorder of sterol and bile acid metabolism cerebrotendinous xanthomatosis (CTX), utilizing a combination of charge-tagging and LC-ESI-MSn performed with an LTQ-Orbitrap Discovery instrument. In addition, we profile sterols in plasma from 24-month-old cyp27A1 gene knockout mice lacking the enzyme defective in CTX. Charge-tagging was accomplished by reaction with cationic Girard\u27s P (GP) reagent 1-(carboxymethyl) pyridinium chloride hydrazide, an approach uniquely suited to studying the 3-oxo sterols that accumulate in CTX, as Girard\u27s reagent reacts with the sterol oxo moiety to form charged hydrazone derivatives. The ability to selectively generate GP-tagged 3-oxo-4-ene and 3-oxo-5(H) saturated plasma sterols enabled ESI-MSn analysis of these sterols in the presence of a large excess (3 orders of magnitude) of cholesterol. Often cholesterol detected in biological samples makes it challenging to quantify minor sterols, with cholesterol frequently removed prior to analysis. We derivatized plasma (10ÎŒl) without SPE removal of cholesterol to ensure detection of all sterols present in plasma. We were able to measure 4-cholesten-3-one in plasma from untreated CTX patients (1207±302ng/ml, mean±SD, n=4), as well as other intermediates in a proposed pathway to 5α-cholestanol. In addition, a number of bile acid precursors were identified in plasma using this technique. GP-tagged sterols were identified utilizing high resolution exact mass spectra (±5ppm), as well as MS2 ([M]+â) spectra that possessed characteristic neutral loss of 79Da (pyridine) fragment ions, and MS3 ([M]+â[M-79]+â) spectra that provided additional structurally informative fragment ions. © 2010 Elsevier B.V
Copper reduces the virulence of bacterial communities at environmentally relevant concentrations
This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: All data and R code used in the analysis is available on GitHub (https://github.com/LukeLear/Lear_et_al_2023_Environment_International.git).Increasing environmental concentrations of metals as a result of anthropogenic pollution are significantly changing many microbial communities. While there is evidence metal pollution can result in increased antibiotic resistance, the effects of metal pollution on the virulence of bacterial communities remains largely undetermined. Here, we experimentally test whether metal stress alters the virulence of bacterial communities. We do this by incubating three wastewater influent communities under different environmentally relevant copper concentrations for three days. We then quantify the virulence of the community phenotypically using the Galleria mellonella infection model, and test if differences are due to changes in the rate of biomass accumulation (productivity), copper resistance, or community composition (quantified using 16S amplicon sequencing). The virulence of the communities was found to be reduced by the highest copper concentration, but not to be affected by the lower concentration. As well as reduced virulence, communities exposed to the highest copper concentration were less diverse and had lower productivity. This work highlights that metal pollution may decrease virulence in bacterial communities, but at a cost to diversity and productivity.Natural Environment Research Council (NERC)UKR
HT2008-56147 PARAMETRIC CONTROL OF A TWO-PHASE THERMAL MANAGEMENT SYSTEM FOR SPACE APPLICATIONS
ABSTRACT As spacecraft increase in complexity, greater power is required to drive their onboard systems. The resulting generation of waste heat demands efficient thermal control, especially for electrical components emitting heat at high flux densities. Weislogel proposed a passive two-phase heat transport system for space application, driven by constant volume boilers, called the pulse thermal loop (PTL). This paper describes four methods of operating a PTL using real-time pressure data as the control parameter. Preliminary results are presented from an experimental loop using R-134a as the working fluid. Control is exercised through algorithm-based schemes implemented in LabVIEW. Results suggest that stable operation of the loop is best achieved by actuating flow control valves in response to a preset pressure difference between the boilers. Control schemes based on absolute pressure, set pulse frequency, and a combination of absolute and differential pressures are also described. Performance data are presented, and some of the challenges faced during PTL operation are discussed, including start-up and asymmetrical pressurization of the boilers
An argument for the use of Aristotelian method in bioethics
The main claim of this paper is that the method outlined and used in Aristotle's Ethics is an appropriate and credible one to use in bioethics. Here âappropriateâ means that the method is capable of establishing claims and developing concepts in bioethics and âcredibleâ that the method has some plausibility, it is not open to obvious and immediate objection. It begins by suggesting why this claim matters and then gives a brief outline of Aristotle's method. The main argument is made in three stages. First, it is argued that Aristotelian method is credible because it compares favourably with alternatives. In this section it is shown that Aristotelian method is not vulnerable to criticisms that are made both of methods that give a primary place to moral theory (such as utilitarianism) and those that eschew moral theory (such as casuistry and social science approaches). As such, it compares favourably with these other approaches that are vulnerable to at least some of these criticisms. Second, the appropriateness of Aristotelian method is indicated through outlining how it would deal with a particular case. Finally, it is argued that the success of Aristotle's philosophy is suggestive of both the credibility and appropriateness of his method.</p
Adsorption and reaction of CO on (Pdâ)Al2O3 and (Pdâ)ZrO2: vibrational spectroscopy of carbonate formation
Îł-Alumina is widely used as an oxide support in catalysis, and palladium nanoparticles supported by alumina represent one of the most frequently used dispersed metals. The surface sites of the catalysts are often probed via FTIR spectroscopy upon CO adsorption, which may result in the formation of surface carbonate species. We have examined this process in detail utilizing FTIR to monitor carbonate formation on Îł-alumina and zirconia upon exposure to isotopically labelled and unlabelled CO and CO2. The same was carried out for well-defined Pd nanoparticles supported on Al2O3 or ZrO2. A water gas shift reaction of CO with surface hydroxyls was detected, which requires surface defect sites and adjacent OH groups. Furthermore, we have studied the effect of Cl synthesis residues, leading to strongly reduced carbonate formation and changes in the OH region (isolated OH groups were partly replaced or were even absent). To corroborate this finding, samples were deliberately poisoned with Cl to an extent comparable to that of synthesis residues, as confirmed by Auger electron spectroscopy. For catalysts prepared from Cl-containing precursors a new CO band at 2164 cmâ1 was observed in the carbonyl region, which was ascribed to Pd interacting with Cl. Finally, the FTIR measurements were complemented by quantification of the amount of carbonates formed via chemisorption, which provides a tool to determine the concentration of reactive defect sites on the alumina surface
Site-specific occurrence of nonmelanoma skin cancers in patients with cutaneous melanoma
In a registry-based caseâcontrol study, we compared the site-specific occurrence of nonmelanoma (keratinocytic) skin cancers among patients with cutaneous melanoma cases (cases, n=3774) and solid tumours (controls, n=349â923), respectively. Overall, patients with melanoma were almost five-fold more likely to develop keratinocytic cancers compared with solid tumour controls (adjusted OR 4.7, 95% CI 4.1â5.3), but the risks varied depending upon the site of melanoma. Whereas patients with melanoma of the head and neck had similarly increased risks of keratinocytic cancers across all body sites, patients with melanoma of the trunk were significantly more likely to develop keratinocyte cancer diagnosed on the trunk (adjusted OR 12.5, 95% CI 7.2â20.2) than on the head and neck (adjusted OR 3.0, 95% CI 2.2â4.3). Similar colocalisation of skin tumours was observed for patients with melanomas of the lower limb. These findings provide support for the hypothesis that skin cancers at different anatomical sites may arise through different causal pathways
Reconfigurable binary optical routing switches with fan-out based on the integration of GaAs/AlGaAs surface-emitting lasers and heterojunction phototransistors
Includes bibliographical references.The design, fabrication, and experimental demonstration of dynamically reconfigurable binary optical switches based on the integration of GaAs/AlGaAs vertical-cavity surface-emitting lasers and heterojunction phototransistors are reported. These new monolithic optical switches can perform spatial routing and optical amplification functions on input optical data with a fan-out of two, and can be programmed using simple voltage control. The 1 Ă 2 and 2 Ă 2 devices provide the basis for a high performance, two-dimensional optical switching fabric with electrical interfaces for optical switching and interconnection networks.The work at UNM was supported by Rome Laboratories (Griffiss AFB), the Advanced Research Projects Agency-MTO, and the Air Force Office of Scientific Research (Bolling AFB). The work performed at Sandia was supported by DOE Contract No. DE-AC04-76DP00789
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