5 research outputs found
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy) : a phase 3, randomized, double-blind, placebo-controlled trial.
- Author
- Akinosoglou Karolina
- Cazenave-Roblot France
- Clevenbergh Philippe
- Courjon Johan
- Dalgard Olav
- Danion François
- de Castro Nathalie
- et al.
- Faure Emmanuel
- Gallien Sébastien
- Garot Denis
- Goehringer François
- Gousseff Marie
- Hajdú Edit
- Hites Maya
- Jamard Simon
- Kollaborációs szervezet: DisCoVeRy study group
- Lacombe Karine
- Lapique Eva Larranaga
- Lescure Xavier
- Leturnier Paul
- Malvy Denis
- Martin-Blondel Guillaume
- Massonnaud Clément R
- Moing Vincent Le
- Piroth Lionel
- Reignier Jean
- Riise Anne Ma Dyrhol
- Roger Claire
- Sellier Pierre
- Staub Thérèse
- Tolsma Violaine
- Trøseid Marius
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial
- Author
- ADER Florence
- AKINOSOGLOU Karolina
- BALLY Isabelle
- BANO Jesus Rodriguez
- BELHADI Drifa
- BELKHIR Leila
- BERGAUD Nathalie
- BILLARD Nicolas
- BOTELHO-NEVERS Elisabeth
- BOUSCAMBERT-DUCHAMP Maude
- BURDET Charles
- CABIE Andre
- CARCELAIN Guislaine
- CAZENAVE-ROBLOT France
- CLEVENBERGH Philippe
- COSTAGLIOLA Dominique
- COUFFIN-CADIERGUES Sandrine
- COURJON Johan
- DALGARD Olav
- DANION Francois
- DE CASTRO Nathalie
- DECHANET Aline
- DELMAS Christelle
- DERGAN-DYLON Sebastian
- DESTRAS Gregory
- DIALLO Alpha
- DISCOVERY STUDY Group
- ESPEROU Helene
- EUSTACE Joe
- FAURE Emmanuel
- FOUGEROU-LEURENT Claire
- GALLIEN Sebastien
- GAROT Denis
- GAYMARD Alexandre
- GOEHRINGER Francois
- GOUSSEFF Marie
- GREIL Richard
- GUEDJ Jeremie
- HAJDU Edit
- HALANOVA Monika
- HAN Thi-Hong-Lien
- HITES Maya
- JAMARD Simon
- JOSSET Laurence
- KALIF Ouifiya
- KOTANIDOU Anastasia
- LACOMBE Karine
- LANTERNIER Fanny
- LAPIQUE Eva Larranaga
- LESCURE Xavier
- LETURNIER Paul
- LEVEAU Benjamin
- LOUBET Paul
- MALVY Denis
- MARTIN-BLONDEL Guillaume
- MASSONNAUD Clement R
- MENTRE France
- MERCIER Noemie
- MESTRE Soizic Le
- METOIS Anabelle
- MOING Vincent Le
- NORET Marion
- PAIVA Jose-Artur
- PEIFFER-SMADJA Nathan
- PIEKARSKA Anna
- PIROTH Lionel
- POIGNARD Pascal
- REIGNIER Jean
- RIISE Anne Ma Dyrhol
- ROGER Claire
- ROUVEIX-NORDON Elisabeth
- SELLIER Pierre
- SILVA Susana
- STAUB Therese
- TERZIC Vida
- THIERY Guillaume
- TOLSMA Violaine
- TONBY Kristian
- TRABAUD Mary-Anne
- TROJANEK Milan
- TROSEID Marius
- TSIODRAS Sotirios
- TUBIANA Sarah
- UNAL Serhat
- VARDON-BOUNES Fanny
- VISEE Clotilde
- YAZDANPANAH Yazdan
- Publication venue
- WB Saunders
- Publication date
- 16/02/2024
- Field of study
International audienc
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial.
- Author
- Ader Florence
- Akinosoglou Karolina
- Bally Isabelle
- Belhadi Drifa
- Belkhir Leïla
- Bergaud Nathalie
- Billard Nicolas
- Botelho-Nevers Élisabeth
- Bouscambert-Duchamp Maude
- Burdet Charles
- Cabié André
- Carcelain Guislaine
- Cazenave-Roblot France
- Clevenbergh Philippe
- Costagliola Dominique
- Couffin-Cadiergues Sandrine
- Courjon Johan
- Dalgard Olav
- Danion François
- de Castro Nathalie
- Dechanet Aline
- Delmas Christelle
- Dergan-Dylon Sebastián
- Destras Grégory
- Diallo Alpha
- DisCoVeRy study group
- Dyrhol Riise Anne Ma
- Esperou Hélène
- Eustace Joe
- Faure Emmanuel
- Fougerou-Leurent Claire
- Gallien Sébastien
- Garot Denis
- Gaymard Alexandre
- Goehringer François
- Gousseff Marie
- Greil Richard
- Guedj Jérémie
- Hajdu Edit
- Halanova Monika
- Han Thi-Hong-Lien
- Hites Maya
- Jamard Simon
- Josset Laurence
- Kalif Ouifiya
- Kotanidou Anastasia
- Lacombe Karine
- Lanternier Fanny
- Lapique Eva Larranaga
- Lescure Xavier
- Leturnier Paul
- Leveau Benjamin
- Loubet Paul
- Malvy Denis
- Martin-Blondel Guillaume
- Massonnaud Clément R
- Mentré France
- Mercier Noémie
- Mestre Soizic Le
- Moing Vincent Le
- Métois Anabelle
- Noret Marion
- Paiva Jose-Artur
- Peiffer-Smadja Nathan
- Piekarska Anna
- Piroth Lionel
- Poignard Pascal
- Reignier Jean
- Rodriguez Baño Jesus
- Roger Claire
- Rouveix-Nordon Elisabeth
- Sellier Pierre
- Silva Susana
- Staub Thérèse
- Terzic Vida
- Thiery Guillaume
- Tolsma Violaine
- Tonby Kristian
- Trabaud Mary-Anne
- Trojánek Milan
- Trøseid Marius
- Tsiodras Sotirios
- Tubiana Sarah
- Unal Serhat
- Vardon-Bounes Fanny
- Visée Clotilde
- Yazdanpanah Yazdan
- Publication venue
- W.B. Saunders
- Publication date
- 01/01/2024
- Field of study
Dear Editor, We read with great interest the recent article by Kamboj et al., in which they described the risk of developing moderate to severe Coronavirus Disease 2019 (COVID-19) in patients with hematological malignancies receiving tixagevimab-cilgavimab (T-C) during a period in which the dominant circulating variants of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) were resistant to T-C.1 The authors highlight the ongoing need to urgently address the mAb treatment gap, particularly for immunocompromised patients. The unmet need is further highlighted by the DisCoVeRy Phase 3, adaptive, multicentre European, randomized, double-blind, superiority trial that evaluated the efficacy and safety of intravenous T-C in SARS-CoV-2 antigenic positive patients (i.e those with a high SARS-CoV-2 viral load) hospitalized with COVID-19 and followed-up to day 90. [...
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adam Elisabeth
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexander Peta MA
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
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- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Bozza Patricia T
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Bryda Petra
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- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
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- Calligy Kate
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- Cantero Mireia
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- Carney Gayle
- Carqueja Inês
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- Carrier François Martin
- Carroll Ida
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- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
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- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
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- Cely Lina Morales
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- Chair Anissa
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- Chan Adrienne
- Chand Meera
- Chantalat Auger Christelle
- Chapplain Jean-Marc
- Charpentier Charlotte
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- Dankwa Emmanuelle A
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- de Brito Carlos Alexandre Antunes
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- de Jong Menno
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- Dechert William
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- Doherty Helen
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- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Eddington Devin P
- Egan Siobhan
- Eira Carla
- Ekow Harrison Samuel Bernard
- El Sanharawi Mohammed
- Elapavaluru Subbarao
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- Everding Anna Greti
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- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J
- Fanning Jonathon P
- Faria Pedro
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- Griffee Matthew J
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- Jenum Synne
- Jimbo-Sotomayor Ruth
- Jiménez Miguel Pedrera
- Joe Ong Yiaw
- Jorge García Ruth N
- Joseph Cédric
- Joseph Mark
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- van den Berge Marcel
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- van der Palen Job
- van der Valk Paul
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- Van der Voort Peter
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- Varrone Michael
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- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 30/06/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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- Abdulkadir N. N.
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings