Measuring differential rotation of the K-giant ζ\zeta\,And

We investigate the temporal spot evolution of the K-giant component in the RS CVn-type binary system $\zeta$\,Andromedae to establish its surface differential rotation. Doppler imaging is used to study three slightly overlapping spectroscopic datasets, obtained independently at three different observing sites. Each dataset covers one full stellar rotation with good phase coverage, and in total, results in a continuous coverage of almost three stellar rotations ($P_{\rm rot}=$17.8\,d). Therefore, these data are well suited for reconstructing surface temperature maps and studying temporal evolution in spot configurations. Surface differential rotation is measured by the means of cross-correlation of all the possible image pairs. The individual Doppler reconstructions well agree in the revealed spot pattern, recovering numerous low latitude spots with temperature contrasts of up to $\approx$1000\,K with respect to the unspotted photosphere, and also an asymmetric polar cap which is diminishing with time. Our detailed cross-correlation study consistently indicate solar-type differential rotation with an average surface shear $\alpha\approx0.055$, in agreement with former results.Comment: accepted for publication in A&A, 4 pages, 3 figure

Towards micro-arcsecond spatial resolution with Air Cherenkov Telescope arrays as optical intensity interferometers

In this poster contribution we highlight the equivalence between an Imaging Air Cherenkov Telescope (IACT) array and an Intensity Interferometer for a range of technical requirements. We touch on the differences between a Michelson and an Intensity Interferometer and give a brief overview of the current IACT arrays, their upgrades and next generation concepts (CTA, AGIS, completion 2015). The latter are foreseen to include 30-90 telescopes that will provide 400-4000 different baselines that range in length between 50m and a kilometre. Intensity interferometry with such arrays of telescopes attains 50 micro-arcseconds resolution for a limiting V magnitude of ~8.5. This technique opens the possibility of a wide range of studies, amongst others, probing the stellar surface activity and the dynamic AU scale circumstellar environment of stars in various crucial evolutionary stages. Here we discuss possibilities for using IACT arrays as optical Intensity Interferometers.Comment: Appeared in the proceedings of "The Universe under the Microscope - Astrophysics at High Angular Resolution", Journal of Physics:Conference Series (IOP; http://www.iop.org/EJ/toc/1742-6596/131/1

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer.

PURPOSE: Angiogenesis and vascular endothelial growth factor (VEGF) expression are associated with a poor outcome in bladder cancer. To understand more about the mechanisms, we studied the role of delta-like 4 (DLL4), an endothelial-specific ligand of the Notch signaling pathway, in bladder cancer angiogenesis. EXPERIMENTAL DESIGN: The expression of DLL4, CD34, and VEGF were studied in a cohort of 60 bladder tumors and 10 normal samples using quantitative PCR. In situ hybridization was used to study the pattern of DLL4 expression in 22 tumor and 9 normal samples. Serial sections were also stained for CD34 and alpha-smooth muscle actin (alpha-SMA) using conventional immunohistochemistry. RESULTS: The expression of DLL4 was significantly up-regulated in superficial (P < 0.01) and invasive (P < 0.05) bladder cancers. DLL4 expression significantly correlated with CD34 (P < 0.001) and VEGF (P < 0.001) expression. The in situ hybridization studies showed that DLL4 was highly expressed within bladder tumor vasculature. Additionally, DLL4 expression significantly correlated with vessel maturation as judged by periendothelial cell expression of alpha-SMA, 98.7% of DLL4-positive tumor vessels coexpressed alpha-SMA, compared with 64.5% of DLL4-negative tumor vessels (P < 0.001). High DLL4 expression may have prognostic value in superficial and invasive bladder. CONCLUSION: DLL4 expression is associated with vascular differentiation in bladder cancer; thus, targeting DLL4 may be a novel antiangiogenic therapy

Planet Formation Imager (PFI): Introduction and Technical Considerations

Complex non-linear and dynamic processes lie at the heart of the planet formation process. Through numerical simulation and basic observational constraints, the basics of planet formation are now coming into focus. High resolution imaging at a range of wavelengths will give us a glimpse into the past of our own solar system and enable a robust theoretical framework for predicting planetary system architectures around a range of stars surrounded by disks with a diversity of initial conditions. Only long-baseline interferometry can provide the needed angular resolution and wavelength coverage to reach these goals and from here we launch our planning efforts. The aim of the "Planet Formation Imager" (PFI) project is to develop the roadmap for the construction of a new near-/mid-infrared interferometric facility that will be optimized to unmask all the major stages of planet formation, from initial dust coagulation, gap formation, evolution of transition disks, mass accretion onto planetary embryos, and eventual disk dispersal. PFI will be able to detect the emission of the cooling, newly-formed planets themselves over the first 100 Myrs, opening up both spectral investigations and also providing a vibrant look into the early dynamical histories of planetary architectures. Here we introduce the Planet Formation Imager (PFI) Project (www.planetformationimager.org) and give initial thoughts on possible facility architectures and technical advances that will be needed to meet the challenging top-level science requirements.Comment: SPIE Astronomical Telescopes and Instrumentation conference, June 2014, Paper ID 9146-35, 10 pages, 2 Figure

Human Listeriosis Caused by Listeria ivanovii

Two species of Listeria are pathogenic; L. monocytogenes infects humans and animals, and L. ivanovii has been considered to infect ruminants only. We report L. ivanovii–associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen

FU Orionis disk outburst: evidence for a gravitational instability scenario triggered in a magnetically dead zone

Context: FUors outbursts are a crucial stage of accretion in young stars. However a complete mechanism at the origin of the outburst still remains missing. Aims: We aim at constraining the instability mechanism in FU Orionis star itself, by directly probing the size and the evolution in time of the outburst region with near-infrared interferometry, and to confront it to physical models of this region. Methods: FU Orionis has been a regular target of near-infrared interferometry. In this paper, we analyze more than 20 years of interferometric observations to perform a temporal monitoring of the region of the outburst, and compare it to the spatial structure deduced from 1D MHD simulations. Results: We measure from the interferometric observations that the size variation of the outburst region is compatible with a constant or slightly decreasing size over time in the H and K band. The temporal variation and the mean sizes are consistently reproduced by our 1D MHD simulations. We find that the most compatible scenario is a model of an outburst occurring in a magnetically layered disk, where a Magneto-Rotational Instability (MRI) is triggered by a Gravitational Instability (GI) at the outer edge of a dead-zone. The scenario of a pure Thermal Instability (TI) fails to reproduce our interferometric sizes since it can only be sustained in a very compact zone of the disk <0.1 AU. The scenario of MRI-GI could be compatible with an external perturbation enhancing the GI, such as tidal interactions with a stellar companion, or a planet at the outer edge of the dead-zone. Conclusions: The layered disk model driven by MRI turbulence is favored to interpret the spatial structure and temporal evolution of FU Orionis outburst region. Understanding this phase gives a crucial link between the early phase of disk evolution and the process of planet formation in the first inner AUs.Comment: Accepted for publication in A&

The near-infrared size-luminosity relations for Herbig Ae/Be disks

We report the results of a sensitive K-band survey of Herbig Ae/Be disk sizes using the 85-m baseline Keck Interferometer. Targets were chosen to span the maximum range of stellar properties to probe the disk size dependence on luminosity and effective temperature. For most targets, the measured near-infrared sizes (ranging from 0.2 to 4 AU) support a simple disk model possessing a central optically-thin (dust-free) cavity, ringed by hot dust emitting at the expected sublimation temperatures (T_sub~1000-1500K). Furthermore, we find a tight correlation of disk size with source luminosity R propto L^(1/2) for Ae and late Be systems (valid over more than 2 decades in luminosity), confirming earlier suggestions based on lower-quality data. Interestingly, the inferred dust-free inner cavities of the highest luminosity sources (Herbig B0-B3 stars) are under-sized compared to predictions of the optically-thin cavity model, likely due to optically-thick gas within the inner AU.Comment: Accepted by Astrophysical Journal; 24 pages, 4 figures, 4 table

Bispectrum speckle interferometry of IRC+10216: the dynamic evolution of the innermost circumstellar environment from 1995 to 2001

We present new near-infrared (JHK) bispectrum speckle-interferometry monitoring of the carbon star IRC+10216 obtained between 1999 and 2001 with the SAO 6m telescope. The J-, H-, and K-band resolutions are 50mas, 56mas, and 73mas, resp. The total sequence of K-band observations covers now 8 epochs from 1995 to 2001 and shows the dynamic evolution of the inner dust shell. The present observations show that the appearance of the dust shell has considerably changed compared to the epochs of 1995 to 1998. Four main components within a 0.2" radius can be identified in the K-band images. The apparent separation of the two initially brightest components A and B increased from ~191mas in 1995 to ~351mas in 2001. Simultaneously, component B has been fading and almost disappeared in 2000 whereas the initially faint components C and D became brighter (relative to peak intensity). These changes can be related to changes of the optical depth caused, e.g., by mass-loss variations or new dust condensation in the wind. Our 2D radiative transfer model suggests that the observed relative motion of A and B is not consistent with the known terminal wind velocity of 15 km/s. The apparent motion with a deprojected velocity of 19 km/s on average and of recently 27 km/s appears to be caused by adisplacement of the dust density peak due to dust evaporation in the optically thicker and hotter environment. Our monitoring, covering more than 3 pulsation periods, shows that the structural variations are not related to the stellar pulsation cycle in a simple way. This is consistent with the predictions of hydrodynamical models that enhanced dust formation takes place on a timescale of several pulsation periods. The timescale of the fading of component B can well be explained by the formation of new dust in the circumstellar envelope.Comment: 11 pages including 6 PostScript figures; also available from http://www.mpifr-bonn.mpg.de/div/ir-interferometry/publications.html; Astronomy & Astrophysics, in pres

Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes.

Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L. monocytogenes can infect non-phagocytic cells by two means: direct invasion and cell-to-cell spread. The relative contribution of each method to placental infection is controversial, as is the anatomical site of invasion. Here, we report for the first time the use of first trimester placental organ cultures to quantitatively analyze L. monocytogenes infection of the human placenta. Contrary to previous reports, we found that the syncytiotrophoblast, which constitutes most of the placental surface and is bathed in maternal blood, was highly resistant to L. monocytogenes infection by either internalin-mediated invasion or cell-to-cell spread. Instead, extravillous cytotrophoblasts-which anchor the placenta in the decidua (uterine lining) and abundantly express E-cadherin-served as the primary portal of entry for L. monocytogenes from both extracellular and intracellular compartments. Subsequent bacterial dissemination to the villous stroma, where fetal capillaries are found, was hampered by further cellular and histological barriers. Our study suggests the placenta has evolved multiple mechanisms to resist pathogen infection, especially from maternal blood. These findings provide a novel explanation why almost all placental pathogens have intracellular life cycles: they may need maternal cells to reach the decidua and infect the placenta

The Small Separation A-star Companion Population: First Results with CHARA/MIRC-X

This is the final version. Available on open access from the American Astronomical Society via the DOI in this recordWe present preliminary results from our long-baseline interferometry (LBI) survey to constrain the multiplicity properties of intermediate-mass A-type stars within 80 pc. Previous multiplicity studies of nearby stars exhibit orbital separation distributions well fitted with a lognormal with peaks >15 au, increasing with primary mass. The A-star multiplicity survey of De Rosa et al., sensitive beyond 30 au but incomplete below 100 au, found a lognormal peak around 390 au. Radial velocity surveys of slowly rotating, chemically peculiar Am stars identified a significant number of very close companions with periods ≤5 days, ∼0.1 au, a result similar to surveys of O- and B-type primaries. With the improved performance of LBI techniques, we can probe these close separations for normal A-type stars where other surveys are incomplete. Our initial sample consists of 27 A-type primaries with estimated masses between 1.44 and 2.49 M ⊙ and ages 10-790 Myr, which we observed with the MIRC-X instrument at the CHARA Array. We use the open-source software CANDID to detect five companions, three of which are new, and derive a companion frequency of 0.19 − 0.06 + 0.11 over mass ratios of 0.25-1.0 and projected separations of 0.288-5.481 au. We find a probability of 10−6 that our results are consistent with extrapolations based on previous models of the A-star companion population over the mass ratios and separations sampled. Our results show the need to explore these very close separations to inform our understanding of stellar formation and evolution processes.European Research Council (ERC