Current medical product development for diagnosis, surgical planning and treatment in the areas of Neurosurgery, Orthopeadic and Dental-Cranio-Maxillofacial surgery in Vietnam

With the population of 86 million and good GDP growth in recent decades, the medical market in Vietnam is growing fast. However, most of the medical technology products are imported, and the number of locally manufactured ones is limited and they do not have the high competition capability in term of quality, quantity and types. In this paper, the current product development in Vietnam for diagnosis, surgical planning and treatment in the areas of Rehabilitation, Neurosurgery, Orthopeadic and Dental-Cranio-Maxillofacial surgery is presented. A roadmap for medical technology development in Vietnam is propose

Medical reverse engineering applications and methods

Understanding, controlling and manipulation of patient data as well as shape, geometry and structure of the biomedical objects are important for developing Biomedical Engineering (BME) applications. Medical Reverse Engineering (MRE) is aimed to use the Reverse Engineering (RE) technology to reconstruct 3D models of the anatomical structures and biomedical objects for design and manufacturing of medical products as well as BME research and development. This paper presents the state of the art applications and methods about MRE. Different concepts and methodologies are provided to understand fundamentally the MRE processes and workflow. The key MRE applications are presented, including personalised implants for bone reconstruction, dental implants and simulations, surgical tools, medical training, vision science and optometry, orthopedics, ergonomics, orthosis, prosthesis, and tissue engineering. The current challenges as well as the hardware and software for MRE application development and research are discussed

Chemical components and biological properties from acetone extracts of Conamomum vietnamense

Conamomum vietnamense is an endemic and rare species from Vietnam. The aim of this study is to determine the chemical compositions, antibacterial and antioxidant properties of the acetone extracts obtained from the different organs of this species for the first time. A total of 82 components were identified from the acetone extracts of leaf, flower, and rhizome of C. vietnamense using Gas chromatography–mass spectrometry (GC/MS) technique. Furthermore, the agar disk-diffusion method was also used to determine the antibacterial activity of the C. vietnamense extracts. Accordingly, the leaf extract was found to be effective against eight out of nine bacterial strains while the flower and rhizome extracts displayed activity against four out of nine tested bacteria. In addition, the three organs of C. vietnamense also possessed the high DPPH scavenging properties. The results of this study indicate that C. vietnamense extracts have the potential to be developed into pharmaceutical products in the future

Interference Analysis for OFDM Transmissions in the Presence of Time-Varying Channel Impairments

This paper is concerned with the detrimental effect of phase noise on the performance of orthogonal frequency division multiplexing (OFDM) transmissions over time-selective channels. In the literature, most of the existing papers analyze the performance of OFDM systems in the presence of either time-selective channels or phase noise. Unlike the existing studies, this paper formulates an approximate expression of signal-to-interference-plus-noise ratio (SINR) at an OFDM receiver in the presence of both phase noise and time-selective channel response. The formulated SINR expression can be used as a guideline in determining appropriate OFDM transmission settings under a given quality-of-service (QoS) requirement. To illustrate the tightness of the approximate SINR formulation, empirical and theoretical values of SINR under different OFDM system settings are presented in this paper

Chemical profiles and biological activities of acetone extracts of nine Annonaceae plants

This study investigated the chemical components and bioactivities of acetone leaf extracts of nine Annonaceae plants collected in the Binh Chau-Phuoc Buu Nature Reserve, Vietnam. A total of 182 constituents were identified, with linolenic acid, diaeudesmin, germacrene D, 1-octadecenoic acid, 8-(3-octyl-2-oxiranyl)-1-octanol, oleic acid, and phenylmethyl ester being the major compounds. The antimicrobial activity of the extracts was evaluated using a disc diffusion assay. Eight of the nine extracts, except for the Mitrephora thorelii extract, showed an inhibition effect against Bacillus cereus and Staphylococcus aureus. The antioxidant activity of the extracts was determined using DPPH assay, and the cytotoxic activity was deter mined using SRB assay. The results showed that the acetone extracts of Artabotrys hexapetalus, Uvularia grandiflora, Polyalthia luensis, Xylopia pierrei, Sphaerocoryne affinis, Desmos cochinchinensis, Uvaria littoralis, Mitrephora thorelii, and Goniothalamus touranensis had significant activity with IC50 for the DPPH radical scavenging activity ranging from 18.56 to 702.33 μg/mL, and the IC50 for the cytotoxic effects ranged from 5.39 to 251.77 μg/mL. Overall, the results obtained provide experimental evidence for the potential use of these plants in medicine and other related fields

Feasibility of wearable monitors to detect heart rate variability in children with hand, foot and mouth disease

Hand foot and mouth disease (HFMD) is caused by a variety of enteroviruses, and occurs in large outbreaks in which a small proportion of children deteriorate rapidly with cardiopulmonary failure. Determining which children are likely to deteriorate is difficult and health systems may become overloaded during outbreaks as many children require hospitalization for monitoring. Heart rate variability (HRV) may help distinguish those with more severe diseases but requires simple scalable methods to collect ECG data.We carried out a prospective observational study to examine the feasibility of using wearable devices to measure HRV in 142 children admitted with HFMD at a children's hospital in Vietnam. ECG data were collected in all children. HRV indices calculated were lower in those with enterovirus A71 associated HFMD compared to those with other viral pathogens.HRV analysis collected from wearable devices is feasible in a low and middle income country (LMIC) and may help classify disease severity in HFMD

Study protocol: The clinical features, epidemiology, and causes of paediatric encephalitis in southern Vietnam

Encephalitis is a major cause of morbidity and mortality worldwide. The clinical syndrome of encephalitis consists of altered mental status, seizures, neurologic signs, and is often accompanied by fever, headache, nausea, and vomiting. The encephalitis in children has been known that more common than in adult, with the incidence rate of infants was 3.9 times higher than that of people 20-44 years of age. The reported incidence of hospitalization attributed to paediatric encephalitis ranged from 3 to 13 admissions per 100,000 children per year with the overall mortality ranging from 0 to 7%. There are however more than 100 pathogens that can cause encephalitis and accurate diagnosis is challenging. Over 50% of patients with encephalitis are left undiagnosed despite extensive laboratory investigations. Furthermore, recent studies in high-income settings have suggested autoimmune encephalitis has now surpassed infectious aetiologies, mainly due to increased awareness and diagnostic capacity, which further challenges routine diagnosis and clinical management, especially in developing countries. There are limited contemporary data on the causes of encephalitis in children in Vietnam. Improving our knowledge of the causative agents of encephalitis in this resource-constrained setting remains critical to informing case management, resource distribution and vaccination strategy. Therefore, we conduct a prospective observational study to characterise the clinical, microbiological, and epidemiological features of encephalitis in a major children’s hospital in southern Vietnam. Admission clinical samples will be collected alongside meta clinical data and from each study participants. A combination of classical assays (serology and PCR) and metagenomic next-generation sequencing will used to identify the causative agents. Undiagnosed patients with clinical presentations compatible with autoimmune encephalitis will then be tested for common forms of the disease. Finally, using direct- and indirect costs, we will estimate the economic burden of hospitalization and seven days post hospital discharge of paediatric encephalitis in our setting

Energy-loss Function for Lead

We study the energy-loss function for lead in the framework of the time-dependent density functional theory, using the full-potential linearized augmented plane-wave plus local orbitals method. The ab initio calculations are performed in the adiabatic local density approximation. The comparison between the obtained energy-loss function for zero momentum transfer with those from reflection electron energy loss spectroscopy measurements and from first-principles calculations shows good agreement