Unsupervised naming of speakers in broadcast TV: using written names, pronounced names or both ?

International audiencePersons identification in video from TV broadcast is a valuable tool for indexing them. However, the use of biometric mod- els is not a very sustainable option without a priori knowledge of people present in the videos. The pronounced names (PN) or written names (WN) on the screen can provide hypotheses names for speakers. We propose an experimental comparison of the potential of these two modalities (names pronounced or written) to extract the true names of the speakers. The names pronounced offer many instances of citation but transcription and named-entity detection errors halved the potential of this modality. On the contrary, the written names detection benefits of the video quality improvement and is nowadays rather robust and efficient to name speakers. Oracle experiments presented for the mapping between written names and speakers also show the complementarity of both PN and WN modalities

TGFβR-SMAD3 signaling induces resistance to PARP inhibitors in the bone marrow microenvironment

Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 expression, and/or loss of DNA double-strand break (DSB) end resection regulation. Here, we identify a constitutive mechanism of resistance to PARPi. We report that the bone marrow microenvironment (BMM) facilitates DSB repair activity in leukemia cells to protect them against PARPi-mediated synthetic lethality. This effect depends on the hypoxia-induced overexpression of transforming growth factor beta receptor (TGFβR) kinase on malignant cells, which is activated by bone marrow stromal cells-derived transforming growth factor beta 1 (TGF-β1). Genetic and/or pharmacological targeting of the TGF-β1-TGFβR kinase axis results in the restoration of the sensitivity of malignant cells to PARPi in BMM and prolongs the survival of leukemia-bearing mice. Our finding may lead to the therapeutic application of the TGFβR inhibitor in patients receiving PARPis

Unsupervised Speaker Identification using Overlaid Texts in TV Broadcast

Poster Session: Speaker Recognition IIIInternational audienceWe propose an approach for unsupervised speaker identification in TV broadcast videos, by combining acoustic speaker diarization with person names obtained via video OCR from overlaid texts. Three methods for the propagation of the overlaid names to the speech turns are compared, taking into account the co-occurence duration between the speaker clusters and the names provided by the video OCR and using a task-adapted variant of the TF-IDF information retrieval coefficient. These methods were tested on the REPERE dry-run evaluation corpus, containing 3 hours of annotated videos. Our best unsupervised system reaches a F-measure of 70.2% when considering all the speakers, and 81.7% if anchor speakers are left out. By comparison, a mono-modal, supervised speaker identification system with 535 speaker models trained on matching development data and additional TV and radio data only provided a 57.5% F-measure when considering all the speakers and 45.7% without anchor

The Vocapia Research ASR Systems for Evalita 2011

Abstract. This document describes the speech recognizers submitted by Vocapia Research to the Evalita 2011 evaluation for the open unconstrained automatic speech recognition (ASR) task. The aim of this evaluation was to perform automatic speech recognition of parliament audio sessions in the Italian language. Two systems were submitted. The primary system has a single decoding pass and was optimized to run in real time. The contrastive system, developed in collaboration with LIMSI-CNRS, has two decoding passes and runs in about 5×RT. The case-insensitive word error rates (WER) of these systems on the Evalita development data are respectively 10.2% and 9.3%

Antibiotic Resistance Profile and Methicillin-Resistant Encoding Genes of Staphylococcus aureus Strains Isolated from Bloodstream Infection Patients in Northern Vietnam

Background:  Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). Nevertheless, there are still limited studies in Northern Vietnam. AIM: This study aimed to determine the antibiotic resistance profile and methicillin-resistant encoding genes of Staphylococcus aureus (S. aureus) causing BSIs in Northern Vietnam. METHODS: The cross-sectional study was done from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests performed at the lab of the hospital. RESULTS:  In 43 S. aureus strains isolating, 53.5 % were MRSA. Distribution of gene for overall, MRSA, and MSSA strains were following: mecA gene (58.1 %; 95.7%, and 15%), femA gene (48.8%, 47.8%, and 50%), femB gene (88.4%, 82.6%, and 95%). Antibiotic resistance was highest in penicillin (100%), followed by erythromycin (65.1%) and clindamycin (60.5%). Several antibiotics were susceptible (100%), including vancomycin, tigecycline, linezolid, quinupristin/dalfopristin. Quinolone group was highly sensitive, include ciprofloxacin (83.7%), levofloxacin (86%) and moxifloxacin (86%). CONCLUSION:  In S. aureus causing BSIs, antibiotic resistance was higher in penicillin, erythromycin, and clindamycin. All strains were utterly susceptible to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin

Antibiotic Resistance Profile and Diversity of Subtypes Genes in Escherichia coli Causing Bloodstream Infection in Northern Vietnam

BACKGROUND: Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). But there are still limited studies in Northern Vietnam. AIM: The aim of the study was to determine the antibiotic resistance profile and characteristics of subtypes genes in Escherichia coli causing BSIs in Northern Vietnam. METHODS: The cross-sectional study was done in the period from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests were performed at the lab of the hospital. RESULTS: In 56 E. coli strains isolating 39.29 % produced ESBL. 100% of the isolates harbored blaTEM gene, but none of them had the blaPER gene. The prevalence of ESBL producers and ESBL non-producers in blaCTX-M gene was 81.82%, and 73.53%, in blaSHV gene was 18.18% and 35.29%. Sequencing results showed three blaTEM subtypes (blaTEM 1, 79, 82), four blaCTX-M subtypes (blaCTX-M-15, 73, 98, 161), and eight blaSHV subtypes (blaSHV 5, 7, 12, 15, 24, 33, 57, 77). Antibiotic resistance was higher in ampicillin (85.71%), trimethoprim/sulfamethoxazole (64.29%) and cephazolin (50%). Antibiotics were still highly susceptible including doripenem (96.43%), ertapenem (94.64%), amikacin (96.43%), and cefepime (89.29%). CONCLUSION: In Escherichia coli causing BSIs, antibiotic resistance was higher in ampicillin, trimethoprim/sulfamethoxazole and cephazolin. Antibiotics was highly susceptible including doripenem, ertapenem, amikacin, and cefepime

QCompere @ REPERE 2013

International audienceWe describe QCompere consortium submissions to the REPERE 2013 evaluation campaign. The REPERE challenge aims at gathering four communities (face recognition, speaker identification, optical character recognition and named entity detection) towards the same goal: multimodal person recognition in TV broadcast. First, four mono-modal components are introduced (one for each foregoing community) constituting the elementary building blocks of our various submissions. Then, depending on the target modality (speaker or face recognition) and on the task (supervised or unsupervised recognition), four different fusion techniques are introduced: they can be summarized as propagation-, classifier-, rule- or graph-based approaches. Finally, their performance is evaluated on REPERE 2013 test set and their advantages and limitations are discussed

QCompere @ REPERE 2013

International audienceWe describe QCompere consortium submissions to the REPERE 2013 evaluation campaign. The REPERE challenge aims at gathering four communities (face recognition, speaker identification, optical character recognition and named entity detection) towards the same goal: multimodal person recognition in TV broadcast. First, four mono-modal components are introduced (one for each foregoing community) constituting the elementary building blocks of our various submissions. Then, depending on the target modality (speaker or face recognition) and on the task (supervised or unsupervised recognition), four different fusion techniques are introduced: they can be summarized as propagation-, classifier-, rule- or graph-based approaches. Finally, their performance is evaluated on REPERE 2013 test set and their advantages and limitations are discussed

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.

Myeloproliferative neoplasms (MPNs) often carry JAK2(V617F), MPL(W515L), or CALR(del52) mutations. Current treatment options for MPNs include cytoreduction by hydroxyurea and JAK1/2 inhibition by ruxolitinib, both of which are not curative. We show here that cell lines expressing JAK2(V617F), MPL(W515L), or CALR(del52) accumulated reactive oxygen species-induced DNA double-strand breaks (DSBs) and were modestly sensitive to poly-ADP-ribose polymerase (PARP) inhibitors olaparib and BMN673. At the same time, primary MPN cell samples from individual patients displayed a high degree of variability in sensitivity to these drugs. Ruxolitinib inhibited 2 major DSB repair mechanisms, BRCA-mediated homologous recombination and DNA-dependent protein kinase-mediated nonhomologous end-joining, and, when combined with olaparib, caused abundant accumulation of toxic DSBs resulting in enhanced elimination of MPN primary cells, including the disease-initiating cells from the majority of patients. Moreover, the combination of BMN673, ruxolitinib, and hydroxyurea was highly effective in vivo against JAK2(V617F)+ murine MPN-like disease and also against JAK2(V617F)+, CALR(del52)+, and MPL(W515L)+ primary MPN xenografts. In conclusion, we postulate that ruxolitinib-induced deficiencies in DSB repair pathways sensitized MPN cells to synthetic lethality triggered by PARP inhibitors