Efekat perkutane koronarne intervencije na prognozu sa akutnim infarktom miokarda bez ST elevacije

Introduction: Data suggest that the prevalence of non ST segment elevation acute coronary syndromes (NSTE-ACS) is higher than that of ST segment elevation myocardial infarction (MI) (STEMI), intrahospital mortality is higher in STEMI, but higher in NSTE-ACS compared to STEMI after 4 years. The aim of the present study is to investigate the effects of percutaneous coronary intervention (PCI) on outcomes in patients with non ST segment elevation MI (NSTEMI). Patients and methods: The present study included 185 patients who survived MI (A group, patients with NSTEMI, treated with PCI and drugs, B group, patients with STEMI, treated with PCI and drugs and C group, patients with NSTEMI, treated with drugs only). An effect of PCI, as well as the predictive value of markers of necrosis, inflammation, renal function, heart failure on intrahospital and posthospital outcomes were investigated. Results: Intrahospital complications appeared more frequently in B group, while posthospital complications, including angina pectoris, hemodynamic instability and MACE (death, reinfarction and coronary artery bypass grafting) appeared more frequently in C group. The strongest predictors of death were the C group, female sex, patients who already suffered from MI, heart rate on admission, glycated hemoglobin, urea and creatinine. Conclusions: The strongest predictors of death were age and heart rate on admission. The average time of survival was significantly shorter in C group, compared to both A and B groups. However, it was not significantly different between A and B groups

Modulacija eksperimentalnog autoimunog encefalomijelitisa (EAE) DA pacova levamizolom

We investigated the influence of an antiparasitic drug, levamisole (2,3,5,6 - tetrahydro - 6- phenyl-imidazo (2,1 - b) thiazole -hydrochloride) with potent immunomodulatory properties on the course and development of experimental autoimmune encepha-lomyelitis (EAE). EAE was induced in female Dark Agouti (DA) rats aged two months by immunization with guinea pig spinal cord in complete Freunds adjuvant. Following immunization animals were subcutaneously treated every other day with 2.2 mg/kg levamisole. The course, development and characteristics of this autoimmune process were monitored as indirect indicators of immune system activity. Our results indicate that in EAE levamisole exerts immunosuppressive effects when administered every other day from the moment of immunization until the end of the disease. This application regime and dose postponed the onset of the first clinical signs, shortened the duration of the disease, abrogated the severity of clinical symptoms and accelerated the recovery of sick animals. In the period of induction and during EAE, levamisole also decreased the severity of changes in the cerebral perivascular spaces. In the peripheral blood of levamisole treated animals with induced EAE, a significant increase of CD4-CD8+ T cells was demonstrated. Furthermore, all rats with induced EAE had decreased numbers of CD4+CD8- T cells in their blood. These changes were in correlation with clinical signs of EAE.U ovom radu su prikazani rezultati ispitivanja anthelmintika levamizola (2,3,5,6 tetrahidro - 6 - fenil - imidazo (2,1 - b) tiazol hidrohlorida) sa snažnim imunomodulatornim svojstvima na tok i razvoj eksperimentalnog autoimunog encefalomijelitisa (EAE). EAE je indukovan imunizacijom ženki pacova soja DA (Dark Agouti) starih dva meseca pomoću homogenata kičmene moždine zamorčeta u kompletnom Freundovom adjuvansu. Posle imunizacije, životinje su tretirane subkutanim injekcijama levamizola (2.2 mg/kg) svaki drugi dan a praćeni su tok, razvoj i karakteristike ovog autoimunog oboljenja kao indirektni indikatori aktivnosti imunološkog sistema. Postignuti rezultati ukazuju dalevamizol ispoljava imunosupresivno delovanje u modelu EAE ako se aplikuje svaki drugi dan od momenta imunizacije do kraja bolesti. Primenjena doza i režim aplikacije odložili su momenat pojavljivanja prvih kliničkih simptoma, skratili trajanje bolesti, ublažili ispoljavanje simptoma i ubrzali oporavak bolesnih životinja. U periodu indukcije i tokom EAE-a levamizol je smanjio stepen promena u cerebralnim perivaskularnim prostorima. U ženskoj krvi ženki pacova sa indukovanim EAE i tretiranim levamizolom uočeno je značajno povećanje broja CD4-CD8+ T ćelija. Osim toga, u obe imunizovane grupe životinja zapaženo je smanjenje broja CD4+CD8- ćelija. Ove promene su bile u skladu sa kliničkom slikom bolesti

Improvement possibilities of the I-V characteristics of PIN photodiodes damaged by gamma irradiation

This paper presents the behavior of PIN photodiodes after combined gamma and neutron irradiation. Different types of PIN photodiodes have been exposed first to gamma and then to neutron irradiation. I-V characteristics (current dependence on voltage) of photodiodes have been measured after each of these irradiations. It has been noted that the photocurrent level after the neutron irradiation is higher than before it, which is not consistent with the current theories about the effects of neutron radiation on semiconductors. In order to explain this behavior of the photodiodes, the Monte Carlo simulation of photon transport through the material has been used. It is proposed that a possible cause for current enhancement are defects in semiconductor created by gamma irradiation and effects of neutron irradiation on these defects. The results can be explained by an intercentre transfer of charge between defects in close proximity to each other. The aim of this paper is to investigate the improvement possibilities of the I-V characteristics of PIN photodiodes, and photodetectors in general, damaged by gamma irradiation. [Projekat Ministarstva nauke Republike Srbije, br. 171007

Ispitivanje efekata različitih elektroterapijskih procedura u tretmanu ankilozirajućeg spondilitisa kod pasa

This paper presents the results of studies on the effects of suppression of chronic pain by currents with low (TENS), medium (Intf) and high (MT) frequencies, in dogs with ankylosing spondilytis. Prior to imaging diagnostics the dogs were clinically observed, trias was estimated, as well as habitus, neurological signs and degree of pain. After a 10 day treatment it was clear that all three treatments resulted in a significant decrease of pain at rest, during activity or during palpation. TENS currents have shown the highest degree of effect. All treated animals have shown improved motility after a few months of therapy. Despite the fact that all animals had an improved clinical picture none of the applied currents resulted in a complete loss of limping. Dogs treated with Intf currents displayed a decrease in muscular atrophy. Motility of the coxofemoural joint was most evident in the group treated with microwaves.U radu su prikazana ispitivanja supresije hroničnog bola pod uticajem struja niske (TENS), srednje (Intf) i visoke (MT) frekvence, kod pasa sa ankilozirajućim spondilitisom. Psi su pre rendgenskog snimanja opservirani, urađena im je procena trijasa, habitusa, a zatim neurološki pregled i određivanje stepena bola. Nakon desetodnevnog tretmana, uočeno je da su sva tri postupka dovela do visoko značajnog smanjenja bola u toku mirovanja ili aktivnosti i pri palpaciji, pri čemu su se isticale TENS struje u odnosu na Intf struje i mikrotalase. Kod tretiranih jedinki je zapažena izraženija motorna aktivnost, a nekoliko meseci od početka lečenja, uz određene kineziterapijske vežbe, psi su bili sa bitno redukovanim simptomima oboljenja. Iako je u svakoj grupi ispitivanih jedinki došlo do poboljš anja stanja, ni jedan terapijski postupak nije doveo do potpunog gubitka hromosti. Jedino je u grupi pacijenata tretiranih sa Intf strujama, došlo do značajnog smanjenja stepena mišićne atrofije, a pokretljivost koksofemoralnih zglobova je bila najizraženija kod pacijenata tretiranih mikrotalasima

The effects of cadmium on the life history traits of Lymantria dispar L.

Gypsy moth (Lymantria dispar L.) females and males were chronically exposed to three sublethal cadmium concentrations (10, 30 and 50 mg/g dry food mass) in order to assess the effects of cadmium on larval and pupal duration, pupal mass and longevity. On average, the presence of cadmium in food did not affect larval duration while shortened pupal duration and reduced pupal mass and longevity were recorded. The most significant effects were obtained at the highest cadmium concentration. Females and males did not differ in sensitivity of life history traits to cadmium exposure. It is concluded that (1) cadmium exerts a strong adverse impact on the growth and development of gypsy moths, and (2) the significance of the cadmium effects depends on the dose.Projekat ministarstva br. 14303

Mogućnosti upotrebe selekcijskog indeksa u proceni priplodne vrednosti krava Holštajn rase u Srbiji

The conducted research was aimed at constructing equations of selection index that would be used in the selection of the Holstein-Friesian breed animals in Serbia. The construction of the selection index includes the most important milk traits observed in standard lactation: milk yield (MY305), milk fat content (% MF305) and protein content (% MP305). The variance and covariance necessary for the construction of selection index are calculated using the mixed model by the method of least squares. The economic value of traits is expressed as a ratio of relative changes in costs per unit of traits included in the selection index. Livestock included in the research produced, in the first standard lactation, an average of 7681 kg of milk with 3.58% milk fat and 3.28% protein. The equation of the selection index presented in the paper is selected from the group of equations of selection index, as an equation with the highest correlation between the equation and the aggregate genotype, which amounted to 0.2156.Sprovedeno istraživanje imalo je za cilj konstruisanje jednačine selekcijskog indeksa koja bi se koristila u odabiru grla holštajn-frizijske rase u Srbiji. U konstrukciju selekcijskog indeksa uključene su najvažnije osobine mlečnosti posmatrane u standardnoj laktaciji: prinos mleka (PM305), sadržaj mlečne masti (%MM305) i sadržaj proteina (%MP305). Varijanse i kovarijanse neophodne za konstrukciju selekcijskog indeksa izračunate su primenom mešovitog modela metodom najmanjih kvadrata. Ekonomska vrednost osobina je izražena kao odnos relativne promene troškova po jedinici osobina uključenih u selekcijski indeks. Grla obuhvaćena istraživanjem prosečno su proizvela u prvoj standardnoj laktaciji 7681 kg mleka sa 3,58 % mlečne masti i 3,28% proteina. Jednačina selekcijskog indeksa prikazana u radu odabrana je iz grupe jednačina selekcijskog indeksa, kao jednačina sa najvećom korelacijom između jednačine i agregatnog genotipa, koja je iznosila 0,2156.