Endothelio- and cardioprotective effects of vitamin B₆ and folic acid in modelling methionine-induced hyperhomocysteinemia

The endotelio- and cardioprotective effects of vitamin B₆ (2 mg/kg) and folic acid (0.2mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studie

Features of the maintenance of independent employments by physical exercises for women

This article discusses the use of classes of physical culture for women, the effect of regular exercise on the body. The necessity of physical education for women, considered the features of self-study, and age peculiarities of the content of lessons for womenВ данной статье рассматривается польза занятий физкультурой для женщин, влияние регулярных физических упражнений на организм. Обоснована необходимость физкультуры для женщин, рассмотрены особенности самостоятельных занятий, а также возрастные особенности содержания занятий для женщи

THE DEVELOPMENT OF LOGICAL THINKING IN JUNIOR STUDENTS THROUGH PROJECT-BASED LEARNING

El artículo da una nueva mirada al método de desarrollo del pensamiento lógico en alumnos de tercer año basado en la correlación entre el modelo original y el que hace posible, a diferencia de los métodos tradicionales, desarrollar el pensamiento del habla, las estructuras intelectuales y las operaciones lógicas de los alumnos de manera más efectiva. . Con la ayuda de los enfoques epistemológico, de actividad sistémica y de entorno, se determina una estrategia para desarrollar el pensamiento lógico de los alumnos a través del aprendizaje basado en proyectos que se basa en la correlación entre el modelo original y el original. Asegura el desarrollo efectivo de a) la actividad intelectual de los escolares b) el pensamiento c) la memoria lógica. El estudio demuestra la efectividad de la tecnología presentada, lo que implica 1) sumergirse en el proyecto, así como especificar sus metas y objetivos; 2) organizar y planificar las actividades de los alumnos; 3) resolver las etapas principales del proyecto; 4) llevar a cabo el proyecto y su presentación; 5) evaluar los resultados. Con base en los datos de la investigación, se destacaron los siguientes criterios: análisis, síntesis, comparación, clasificación, generalización y algunos otros criterios que permitieron determinar tres niveles del desarrollo del fenómeno en cuestión. Nuestro método proporciona una mejora significativa de los resultados de la investigación y garantiza la formación de actividades de investigación, informativas, regulatorias y analíticas de aprendizaje universal (ULA). La evaluación de la efectividad y validez del método propuesto se corrobora mediante cálculos para el criterio de Fisher (criterio φ *). Los resultados comparativos de la investigación antes y después del experimento a alto nivel son 3.564. Los valores empíricos obtenidos de φ * están en el área de significancia. H0 se rechaza (el eje de significancia = 1.64–2.31). Por lo tanto, el método en cuestión tiene un grave impacto en el desarrollo del pensamiento lógico a través del aprendizaje basado en proyectos de alumnos menores.O artigo analisa o método de desenvolver o raciocínio lógico em alunos juniores com base na correlação entre o original e o modelo e possibilita, diferentemente dos métodos tradicionais, desenvolver o raciocínio, estruturas intelectuais e operações lógicas dos alunos de maneira mais eficaz. Com o auxílio das abordagens epistemológicas, de atividade sistêmica e do meio, é determinada uma estratégia para o desenvolvimento do pensamento lógico dos alunos por meio da aprendizagem baseada em projetos, baseada na correlação entre o original e o modelo. Garante o desenvolvimento efetivo de a) atividade intelectual das crianças em idade escolar b) pensamento c) memória lógica. O estudo comprova a eficácia da tecnologia apresentada, que implica 1) imersão no projeto, além de especificar suas metas e objetivos; 2) organização e planejamento das atividades dos alunos; 3) elaboração das principais etapas do projeto; 4) realização do projeto e sua apresentação; 5) avaliando os resultados. Com base nos dados da pesquisa, foram destacados os seguintes critérios: análise, síntese, comparação, classificação, generalização e outros critérios que permitiram determinar três níveis de desenvolvimento do fenômeno em questão. Nosso método fornece uma melhoria significativa dos resultados da pesquisa e garante a formação de atividades de aprendizagem universais (ULAs) informativas, regulatórias e analíticas. A avaliação da eficácia e validade do método proposto é corroborada por cálculos para o critério de Fisher (critério φ *). Os resultados comparativos da pesquisa antes e após o experimento em alto nível são 3.564. Os valores empíricos obtidos de φ * estão na área de significância. H0 é rejeitado (o eixo de significância = 1.64-2.31). Assim, o método em questão tem um sério impacto no desenvolvimento do pensamento lógico através da aprendizagem baseada em projetos de alunos juniores.The article takes a new look at the method of developing logical thinking in junior students based on the correlation between the original and the model and making it possible, unlike traditional methods, to develop students’ speech thinking, intellectual structures, and logical operations more effectively. With the aid of the epistemological, systemic-activity, and milieu approaches, a strategy for developing students’ logical thinking through project-based learning that is premised on the correlation between the original and the model is determined. It ensures the effective development of a) schoolchildren’s intellectual activity b) thinking c) logical memory. The study proves the effectiveness of the presented technology, that implies 1) immersing in the project as well as specifying its goals and objectives; 2) organizing and planning students’ activities; 3) working out the main stages of the project; 4) carrying out the project and its presentation; 5) evaluating the results. Based on the research data, the following criteria were singled out analysis, synthesis, comparison, classification, generalization, and some other criteria, which allowed determining three levels of the development of the phenomenon in question. Our method provides for a significant improvement of the results of the research and ensures the formation of research, informational, regulatory, and analytical universal learning activities (ULAs). The assessment of the effectiveness and validity of the proposed method are corroborated by calculations for the Fisher’s criterion (φ*-criterion). The comparative results of the research before and after the experiment at the high level are 3.564. The obtained empirical values of φ * are in the area of significance. H0 is rejected (the significance axis = 1.64–2.31). Thus, the method in question has a serious impact on the development of logical thinking through project-based learning of junior students

Semantic features of the phraseological units with the component light within the artistic discourse

Conduct lexical and semantic analysis on the concept light in the artistic discourse of postmodern fictio

Development of structural components of future technicians’ professional competencies during their studies of general disciplines in college

The relevance of the problem stems from the necessity to develop and implement the formation model for structural components of future technicians’ professional competencies during their studies of general professional disciplines. The purpose of the article is to carry out a theoretical study, to develop and approbate a model that forms the structural components of future maintenance and repair of automobile technicians’ professional competencies during their studies of general professional discipline “Materials science”. The leading method towards studies of this problem is technologies and methods of educational process modeling; works on educational research methodology. The article theoretically proves, develops and approbates a formation model for future maintenance and repair of automobiles technicians’ professional competencies during their studies of general professional discipline “Materials science”. This article may be useful for developing the competence-oriented content for training courses aimed at the formation of structural components of professional competencies. © 2016 Kopilov et al

RENAL SYMPTOM: VARIANTS OF INTERPRETATION

Clinical task.Parents of a 3.5-year-old girl consulted a doctor due to the girl’s unusual urine color.The day before the girl had been complaining of pains in the lower abdomen. The girl urinated at night; in the morning the father discovered that the urine was bright crimson

Reengineering of construction organizations and reengineering of the construction industry

The change of technological and managerial processes caused by scientific and technological progress and designated in the state strategy as the digital transformation should be reflected in the qualitative transformation of organizational structures and methods of implementation of investment and construction activities both at the corporate level and at the industry level. This qualitative transformation is commonly referred to as re-engineering. As a practice and as a methodology reengineering has in its genesis certain phenomena, and for justification uses theoretical tools advised by them. In this regard, the authors in the article argue that digital transformation should be a component of a deeper change in the sectors of the national economy -technological transformation. In terms of practical value reengineering for the industry and its corporate level can be seen as an effective technology for managing the timing and cost of construction, taking into account the needs of the population in the formation of a comfortable and safe environment of life

IDENTIFICATION OF GEOCHEMICAL MARKERS OF VOLCANISM BY THE CLUSTER ANALYSIS FOR THE BOTTOM SEDIMENTS OF THE THERMAL LAKE FUMAROLNОЕ ACCORDING TO SR-XRF

We carried out layer-by-layer scanning (with a step of 1 mm) of the bottom sediments of the thermal lake Fumarolnое with SR-XRF (X-ray fluorescence analysis using synchrotron radiation). The lake is located in the caldera of the Uzon volcano (Kamchatka). The section of the bottom sediments of lake IV Fumarolnое covering the time interval from 260 AD to 2012 is diverse in chemical and mineral composition. Two pyroclastic horizons are observed. The chemical composition of the bottom sediments showed the presence of different layers in which such chemical elements as: Ca, Sr, As, Sb, Mo. Cluster analysis performed for chemical elements revealed the boundaries of layers with different geochemical characteristics. The boundaries of these layers coincide with the horizons identified by mineralogical analysis. At the same time, statistical methods of geochemical data processing allowed unambiguously identifying pyroclastic horizons by elemental composition. We show that the data of SR-XRF analysis in conjunction with cluster analysis can be used to separate the gravity core into layers. The data are in good agreement with the separation data into layers using mineralogical methods

Enzymatic characterization of blood lymphocytes in various clinical and pathogenetic variants of respiratory allergy

Allergy is a sufficient social and economic issue of modern times. Altered immunity in allergic disorders is based, mainly, on the lymphocyte disturbances.Immune characteristics depend both on populations and subpopulational profile of immune cells, and on intrinsic intensity and specific features of theirintracellular metabolism. Interest to studies of intracellular metabolism of lymphocytes id determined by high-scale energetic and plastic processes aimed for support of immune homeostasis. The aim of this study was to evaluate the state of intracellular metabolism in peripheral blood lymphocytes from the patients with respiratory allergies of different genesis and respiratory affection.The study included patients with various clinical variants of respiratory allergy (n = 152) at the age of 21 to 63 years old, and virtually healthy blood donors (n = 209), comparable for age and sex. Within these cohorts, we have separately analyzed, e.g., respiratory atopy (atopic rhinosinusitis and atopic bronchial asthma), as well as respiratory pseudoatopy (polypous rhinosinusitis and asthmatic triad). Allergic disorders of upper respiratory ways were diagnosed in a complex clinical examination by allergologist/immunologist and otorhinolaryngologists. Bronchial asthma verification was based on current GINA criteria (2014). We used m standard common clinical methods and specific allergological diagnostics, e.g., allergological anamnesis, skin prick tests, with different non-infectious allergens, measurement of total and specific IgE’s with ELISA method. The parameters of intracellular metabolism of peripheral blood lymphocytes were determined with bioluminescent technique with bacterial luciferase. Actifity of NAD(P) and NAD(P)H enzymes was measured.Dehydrogenase activities in lymphocytes were expressed as enzyme un its (EU, 1 unit = 1 mcmol/min) per 104 cells.Certain changes of intracellular activities in peripheral lymphocytes are revealed, dependent on genesis and origin of allergic inflammation, and affection level of respiratory ways. In respiratory atopy (atopic rhinosinusitis and atopic bronchial asthma), irrelevant on the level of respiratory affection, the activities of intracellular enzymes suggest increased plastic processes that are maximally pronounced in atopic bronchial asthma. In respiratory pseudoatopy (polypous rhinosinusitis and asthmatic triad) the metabolic changes of lymphocytes presume activation of both plastic and energetic processes, with decreased intensity in asthmatic triad condition. Independent on genesis of respiratory allergic inflammation, we have determined low activity of NAD(P)-dependent glutamate dehydrogenase, and NAD(H)-dependent lactate dehydrogenase in allergic inflammation of upper respiratory ways (atopic rhinosinusitis and polypous). Its activity is statistically higher in bronchial asthma (atopic bronchial asthma and asthmatic triad