370 research outputs found
Gamma ray production cross sections in proton induced reactions on natural Mg, Si and Fe targets over the proton energy range 30 up to 66 MeV
Gamma-ray excitation functions have been measured for 30, 42, 54 and 66 MeV
proton beams accelerated onto C + O (Mylar), Mg, Si, and Fe targets of
astrophysical interest at the separate-sector cyclotron of iThemba LABS in
Somerset West (Cape Town, South Africa). A large solid angle, high energy
resolution detection system of the Eurogam type was used to record Gamma-ray
energy spectra. Derived preliminary results of Gamma-ray line production cross
sections for the Mg, Si and Fe target nuclei are reported and discussed. The
current cross section data for known, intense Gamma-ray lines from these nuclei
consistently extend to higher proton energies previous experimental data
measured up to Ep ~ 25 MeV at the Orsay and Washington tandem accelerators.
Data for new Gamma-ray lines observed for the first time in this work are also
reported.Comment: 11 pages, 6 figures. IOP Institute of Physics Conference Nuclear
Physics in Astrophysics VII, 28th EPF Nuclear Physics Divisional Conference,
May 18-22 2015, York, U
Spider Optimization: Probing the Systematics of a Large Scale B-Mode Experiment
Spider is a long-duration, balloon-borne polarimeter designed to measure
large scale Cosmic Microwave Background (CMB) polarization with very high
sensitivity and control of systematics. The instrument will map over half the
sky with degree angular resolution in I, Q and U Stokes parameters, in four
frequency bands from 96 to 275 GHz. Spider's ultimate goal is to detect the
primordial gravity wave signal imprinted on the CMB B-mode polarization. One of
the challenges in achieving this goal is the minimization of the contamination
of B-modes by systematic effects. This paper explores a number of instrument
systematics and observing strategies in order to optimize B-mode sensitivity.
This is done by injecting realistic-amplitude, time-varying systematics in a
set of simulated time-streams. Tests of the impact of detector noise
characteristics, pointing jitter, payload pendulations, polarization angle
offsets, beam systematics and receiver gain drifts are shown. Spider's default
observing strategy is to spin continuously in azimuth, with polarization
modulation achieved by either a rapidly spinning half-wave plate or a rapidly
spinning gondola and a slowly stepped half-wave plate. Although the latter is
more susceptible to systematics, results shown here indicate that either mode
of operation can be used by Spider.Comment: 15 pages, 12 figs, version with full resolution figs available here
http://www.astro.caltech.edu/~lgg/spider_front.ht
A non perturbative approach of the principal chiral model between two and four dimensions
We investigate the principal chiral model between two and four dimensions by
means of a non perturbative Wilson-like renormalization group equation. We are
thus able to follow the evolution of the effective coupling constants within
this whole range of dimensions without having recourse to any kind of small
parameter expansion. This allows us to identify its three dimensional critical
physics and to solve the long-standing discrepancy between the different
perturbative approaches that characterizes the class of models to which the
principal chiral model belongs.Comment: 5 pages, 1 figure, Revte
Dark Cutting Incidence in Holstein Friesian, Brown Swiss and Eastern Anatolian Red Cattle Slaughtered Under Turkish Commercial Slaughter Conditions
High-dose chemotherapy and autologous stem cell transplantation in enteropathy-associated and other aggressive T-cell lymphomas: a UK NCRI/Cancer Research UK Phase II Study
Octupole correlations in the structure of O2 bands in the N=88 nuclei150Sm Gd
Knowledge of the exact microscopic structure of the 01
+ ground state and first excited 02
+ state in 150Sm is
required to understand the branching of double β decay to these states from 150Nd. The detailed spectroscopy of
150Sm and 152Gd has been studied using (α,xn) reactions and the γ -ray arrays AFRODITE and JUROGAM II.
Consistently strong E1 transitions are observed between the excited KĎ€ = 02
+ bands and the lowest negative
parity bands in both nuclei. These results are discussed in terms of the possible permanent octupole deformation
in the first excited KĎ€ = 02
+ band and also in terms of the “tidal wave” model of Frauendorf.Web of Scienc
Validity, Reliability, and Differential Item Functioning of English and French Versions of the 10-Item Connor-Davidson Resilience Scale in Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study
Objective
Some individuals with systemic sclerosis (SSc) report positive mental health, despite severe disease manifestations, which may be associated with resilience, but no resilience measure has been validated in SSc. This study was undertaken to assess the validity, reliability, and differential item functioning (DIF) between English- and French-language versions of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) in SSc.
Methods
Eligible participants were enrolled in the Scleroderma Patient-centered Intervention Network Cohort and completed the CD-RISC-10 between August 2022 and January 2023. We used confirmatory factor analysis (CFA) to evaluate the CD-RISC-10 factor structure and conducted DIF analysis across languages with Multiple Indicators Multiple Causes models. We tested convergent validity with another measure of resilience and measures of self-esteem and depression and anxiety symptoms. We assessed internal consistency and test–retest reliability using Cronbach\u27s alpha and intraclass correlation coefficient (ICC).
Results
A total of 962 participants were included in this analysis. CFA supported a single-factor structure (Tucker–Lewis index = 0.99, comparative fit index = 0.99, root mean square error of approximation = 0.08 [90% confidence interval (90% CI) 0.07, 0.09]). We found no meaningful DIF. Internal consistency was high (α = 0.93 [95% CI 0.92, 0.94]), and we found that correlations with other measures of psychological functioning were moderate to large (|r| = 0.57–0.78) and confirmed study hypotheses. The scale showed good 1–2-week test–retest reliability (ICC 0.80 [95% CI 0.75, 0.85]) in a subsample of 230 participants.
Conclusion
The CD-RISC-10 is a valid and reliable measure of resilience in SSc, with score comparability across English and French versions
Impact of Cellular miRNAs on Circulating miRNA Biomarker Signatures
Effective diagnosis and surveillance of complex multi-factorial disorders such as cancer can be improved by screening of easily accessible biomarkers. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations in CNA levels are strong predictors of the utility of this biomarker class as promising clinical indicators. Towards this goal microRNAs (miRNAs) representing a class of naturally occurring small non-coding RNAs of 19–25 nt in length have emerged as an important set of markers that can associate their specific expression profiles with cancer development. In this study we investigate some of the pre-analytic considerations for isolating plasma fractions for the study of miRNA biomarkers. We find that measurement of circulating miRNA levels are frequently confounded by varying levels of cellular miRNAs of different hematopoietic origins. In order to assess the relative proportions of this cell-derived class, we have fractionated whole blood into plasma and its ensuing sub-fractions. Cellular miRNA signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating miRNA species investigated in subsets of healthy males and females
Nonperturbative renormalization group approach to frustrated magnets
This article is devoted to the study of the critical properties of classical
XY and Heisenberg frustrated magnets in three dimensions. We first analyze the
experimental and numerical situations. We show that the unusual behaviors
encountered in these systems, typically nonuniversal scaling, are hardly
compatible with the hypothesis of a second order phase transition. We then
review the various perturbative and early nonperturbative approaches used to
investigate these systems. We argue that none of them provides a completely
satisfactory description of the three-dimensional critical behavior. We then
recall the principles of the nonperturbative approach - the effective average
action method - that we have used to investigate the physics of frustrated
magnets. First, we recall the treatment of the unfrustrated - O(N) - case with
this method. This allows to introduce its technical aspects. Then, we show how
this method unables to clarify most of the problems encountered in the previous
theoretical descriptions of frustrated magnets. Firstly, we get an explanation
of the long-standing mismatch between different perturbative approaches which
consists in a nonperturbative mechanism of annihilation of fixed points between
two and three dimensions. Secondly, we get a coherent picture of the physics of
frustrated magnets in qualitative and (semi-) quantitative agreement with the
numerical and experimental results. The central feature that emerges from our
approach is the existence of scaling behaviors without fixed or pseudo-fixed
point and that relies on a slowing-down of the renormalization group flow in a
whole region in the coupling constants space. This phenomenon allows to explain
the occurence of generic weak first order behaviors and to understand the
absence of universality in the critical behavior of frustrated magnets.Comment: 58 pages, 15 PS figure
Identification of Mouse Serum miRNA Endogenous References by Global Gene Expression Profiles
MicroRNAs (miRNAs) are recently discovered small non-coding RNAs and can serve as serum biomarkers for disease diagnosis and prognoses. Lack of reliable serum miRNA endogenous references for normalization in miRNA gene expression makes single miRNA assays inaccurate. Using TaqMan® real-time PCR miRNA arrays with a global gene expression normalization strategy, we have analyzed serum miRNA expression profiles of 20 female mice of NOD/ShiLtJ (n = 8), NOR/LtJ (n = 6), and C57BL/6J (n = 6) at different ages and disease conditions. We identified five miRNAs, miR-146a, miR-16, miR-195, miR-30e and miR-744, to be stably expressed in all strains, which could serve as mouse serum miRNA endogenous references for single assay experiments
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