4,037 research outputs found

    The Nature of Reasoning in John Henry Cardinal Newman\u27s Grammer of Assent

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    Low mass binary neutron star mergers : gravitational waves and neutrino emission

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    Neutron star mergers are among the most promising sources of gravitational waves for advanced ground-based detectors. These mergers are also expected to power bright electromagnetic signals, in the form of short gamma-ray bursts, infrared/optical transients, and radio emission. Simulations of these mergers with fully general relativistic codes are critical to understand the merger and post-merger gravitational wave signals and their neutrinos and electromagnetic counterparts. In this paper, we employ the SpEC code to simulate the merger of low-mass neutron star binaries (two 1.2M⊙1.2M_\odot neutron stars) for a set of three nuclear-theory based, finite temperature equations of state. We show that the frequency peaks of the post-merger gravitational wave signal are in good agreement with predictions obtained from simulations using a simpler treatment of gravity. We find, however, that only the fundamental mode of the remnant is excited for long periods of time: emission at the secondary peaks is damped on a millisecond timescale in the simulated binaries. For such low-mass systems, the remnant is a massive neutron star which, depending on the equation of state, is either permanently stable or long-lived. We observe strong excitations of l=2, m=2 modes, both in the massive neutron star and in the form of hot, shocked tidal arms in the surrounding accretion torus. We estimate the neutrino emission of the remnant using a neutrino leakage scheme and, in one case, compare these results with a gray two-moment neutrino transport scheme. We confirm the complex geometry of the neutrino emission, also observed in previous simulations with neutrino leakage, and show explicitly the presence of important differences in the neutrino luminosity, disk composition, and outflow properties between the neutrino leakage and transport schemes.Comment: Accepted by PRD; 23 pages; 24 figures; 4 table

    Post-merger evolution of a neutron star-black hole binary with neutrino transport

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    We present a first simulation of the post-merger evolution of a black hole-neutron star binary in full general relativity using an energy-integrated general relativistic truncated moment formalism for neutrino transport. We describe our implementation of the moment formalism and important tests of our code, before studying the formation phase of a disk after a black hole-neutron star merger. We use as initial data an existing general relativistic simulation of the merger of a neutron star of 1.4 solar mass with a black hole of 7 solar mass and dimensionless spin a/M=0.8. Comparing with a simpler leakage scheme for the treatment of the neutrinos, we find noticeable differences in the neutron to proton ratio in and around the disk, and in the neutrino luminosity. We find that the electron neutrino luminosity is much lower in the transport simulations, and that the remnant is less neutron-rich. The spatial distribution of the neutrinos is significantly affected by relativistic effects. Over the short timescale evolved, we do not observe purely neutrino-driven outflows. However, a small amount of material (3e-4Msun) is ejected in the polar region during the circularization of the disk. Most of that material is ejected early in the formation of the disk, and is fairly neutron rich. Through r-process nucleosynthesis, that material should produce high-opacity lanthanides in the polar region, and could thus affect the lightcurve of radioactively powered electromagnetic transients. We also show that by the end of the simulation, while the bulk of the disk is neutron-rich, its outer layers have a higher electron fraction. As that material would be the first to be unbound by disk outflows on longer timescales, the changes in Ye experienced during the formation of the disk could have an impact on the nucleosynthesis outputs from neutrino-driven and viscously-driven outflows. [Abridged]Comment: 29 pages, 25 figure

    Isolation of Novel Trypanosomatid, Zelonia australiensis sp. nov. (Kinetoplastida: Trypanosomatidae) Provides Support for a Gondwanan Origin of Dixenous Parasitism in the Leishmaniinae

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    © 2017 Barratt et al. The genus Leishmania includes approximately 53 species, 20 of which cause human leishmaniais; a significant albeit neglected tropical disease. Leishmaniasis has afflicted humans for millennia, but how ancient is Leishmania and where did it arise? These questions have been hotly debated for decades and several theories have been proposed. One theory suggests Leishmania originated in the Palearctic, and dispersed to the New World via the Bering land bridge. Others propose that Leishmania evolved in the Neotropics. The Multiple Origins theory suggests that separation of certain Old World and New World species occurred due to the opening of the Atlantic Ocean. Some suggest that the ancestor of the dixenous genera Leishmania, Endotrypanum and Porcisia evolved on Gondwana between 90 and 140 million years ago. In the present study a detailed molecular and morphological characterisation was performed on a novel Australian trypanosomatid following its isolation in Australia’s tropics from the native black fly, Simulium (Morops) dycei Colbo, 1976. Phylogenetic analyses were conducted and confirmed this parasite as a sibling to Zelonia costaricensis, a close relative of Leishmania previously isolated from a reduviid bug in Costa Rica. Consequently, this parasite was assigned the name Zelonia australiensis sp. nov. Assuming Z. costaricensis and Z. australiensis diverged when Australia and South America became completely separated, their divergence occurred between 36 and 41 million years ago at least. Using this vicariance event as a calibration point for a phylogenetic time tree, the common ancestor of the dixenous genera Leishmania, Endotrypanum and Porcisia appeared in Gondwana approximately 91 million years ago. Ultimately, this study contributes to our understanding of trypanosomatid diversity, and of Leishmania origins by providing support for a Gondwanan origin of dixenous parasitism in the Leishmaniinae

    Genetic Evidence for Selective Transport of Opsin and Arrestin by Kinesin-II in Mammalian Photoreceptors

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    AbstractTo test whether kinesin-II is important for transport in the mammalian photoreceptor cilium, and to identify its potential cargoes, we used Cre-loxP mutagenesis to remove the kinesin-II subunit, KIF3A, specifically from photoreceptors. Complete loss of KIF3A caused large accumulations of opsin, arrestin, and membranes within the photoreceptor inner segment, while the localization of α-transducin was unaffected. Other membrane, organelle, and transport markers, as well as opsin processing appeared normal. Loss of KIF3A ultimately caused apoptotic photoreceptor cell death similar to a known opsin transport mutant. The data suggest that kinesin-II is required to transport opsin and arrestin from the inner to the outer segment and that blocks in this transport pathway lead to photoreceptor cell death as found in retinitis pigmentosa

    The Central Laser Facility at the Pierre Auger Observatory

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    The Central Laser Facility is located near the middle of the Pierre Auger Observatory in Argentina. It features a UV laser and optics that direct a beam of calibrated pulsed light into the sky. Light scattered from this beam produces tracks in the Auger optical detectors which normally record nitrogen fluorescence tracks from cosmic ray air showers. The Central Laser Facility provides a "test beam" to investigate properties of the atmosphere and the fluorescence detectors. The laser can send light via optical fiber simultaneously to the nearest surface detector tank for hybrid timing analyses. We describe the facility and show some examples of its many uses.Comment: 4 pages, 5 figures, submitted to 29th ICRC Pune Indi

    Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

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    AbstractWe screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials

    A ROSAT HRI survey of bright nearby galaxies

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    We use the extensive public archive of ROSAT High Resolution Imager (HRI) observations to carry out a statistical investigation of the X-ray properties of nearby galaxies. Specifically we focus on the sample of 486 bright (B_T < 12.5) northern galaxies studied by Ho, Filippenko and Sargent (HFS) in the context of their exploration of the optical spectroscopic properties of nearby galactic nuclei. Over 20% of HFS galaxies are encompassed in ROSAT HRI fields of reasonable (> 10ks) exposure. The X-ray sources detected within the optical extent of each galaxy are categorised as either nuclear or non-nuclear depending on whether the source is positioned within or outside of a 25 arcsecond radius circle centred on the optical nucleus. A nuclear X-ray source is detected in over 70% of the galaxies harbouring either a Seyfert or LINER nucleus compared to a detection rate of only ~40% in less active systems. The correlation of the H alpha luminosity with nuclear X-ray luminosity previously observed in QSOs and bright Seyfert 1 galaxies appears to extend down into the regime of ultra-low luminosity (L(x)~10^38 - 10^40 erg/s) active galactic nuclei (AGN). The inferred accretion rates for this sample of low-luminosity AGN are significantly sub-Eddington. In total 142 non-nuclear sources were detected. In combination with published data for M31 this leads to a luminosity distribution (normalised to an optical blue luminosity of L(B) = 10^10 L(solar)) for the discrete X-ray source population in spiral galaxies of the form dN/dL38 = 1.0 +/- 0.2 L38^-1.8, where L38 is the X-ray luminosity in units of 10^38 erg/s. The implied L(x)/L(B) ratio is ~1.1 x 10^39 erg/s/(10^10 L(solar)). The nature of the substantial number of ``super-luminous'' non-nuclear objects detected in the survey is discussed.Comment: 20 pages, 7 figures, accepted for publication in MNRAS. Also available from http://www.star.le.ac.uk/~tro/papers/xhfs.p
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