Type 1 2HDM as effective theory of supersymmetry

It is generally believed that the low energy effective theory of the minimal supersymmetric standard model is the type 2 two Higgs doublet model. We will show that the type 1 two Higgs doublet model can also as the effective of supersymmetry in a specific case with high scale supersymmetry breaking and gauge mediation. If the other electroweak doublet obtain the vacuum expectation value after the electroweak symmetry breaking, the Higgs spectrum is quite different. A remarkable feature is that the physical Higgs boson mass can 125 GeV unlike in the ordinary models with high scale supersymmetry in which the Higgs mass is generally around 140 GeV.Comment: 11 pages, 3 figures, Published in Commun.Theor.Phy

Crime and Punishment in Gold Country : A Historical Case-Study

Rural life, small town life, is not and has never been idyllic. It has always had its share of pathology, sometimes deep pathology. Small town life is not necessarily traditional life, close-knit family life, neighborly life. That kind of life certainly exists; but America was never a traditional society in that sense. Its small towns were full of strangers. The population of El Dorado County, small as it was, had been growing rapidly. Like America in general, El Dorado County had its share of anomie; rootless men (and women), without strong relationships: ships without anchors, driftwood on the sea of society. Most of the defendants had families, but (apparently) not successful families. Life was a steady downward slide. Some defendants, perhaps, would eventually be able to patch together a reasonably successful life. For some, their brush with the law might even have been at least mildly deterrent or therapeutic. Teaching a lesson is, after all, one of the goals of criminal justice. How often this happens is a question these files cannot answer. The chronicles revealed in the files of El Dorado County are on the whole chronicles of wasted lives, chronicles of chronic and dismal failure

HZETRN: A heavy ion/nucleon transport code for space radiations

The galactic heavy ion transport code (GCRTRN) and the nucleon transport code (BRYNTRN) are integrated into a code package (HZETRN). The code package is computer efficient and capable of operating in an engineering design environment for manned deep space mission studies. The nuclear data set used by the code is discussed including current limitations. Although the heavy ion nuclear cross sections are assumed constant, the nucleon-nuclear cross sections of BRYNTRN with full energy dependence are used. The relation of the final code to the Boltzmann equation is discussed in the context of simplifying assumptions. Error generation and propagation is discussed, and comparison is made with simplified analytic solutions to test numerical accuracy of the final results. A brief discussion of biological issues and their impact on fundamental developments in shielding technology is given

BRYNTRN: A baryon transport computer code, computation procedures and data base

The development is described of an interaction data base and a numerical solution to the transport of baryons through the arbitrary shield material based on a straight ahead approximation of the Boltzmann equation. The code is most accurate for continuous energy boundary values but gives reasonable results for discrete spectra at the boundary with even a relatively coarse energy grid (30 points) and large spatial increments (1 cm in H2O)

The Warm Glow of Restaurant Checkout Charity

Checkout charity is a phenomenon whereby frontline employees (or self-service technologies) solicit charitable donations from customers during the payment process. Despite its growing ubiquity, little is known about this salient aspect of the service experience. The present research examines checkout charity in the context of fast-food restaurants and finds that, when customers donate, they experience a “warm glow” that mediates a relationship between donating and store repatronage. Study 1 utilizes three scenario-based experiments to explore the phenomenon across different charities and different participant populations using both self-selection and random assignment designs. Study 2 replicates with a field study. Study 3 examines national store–level sales data from a fast-food chain and finds that checkout fund-raising, as a percentage of sales, predicts store revenue—a finding consistent with results of Studies 1 and 2. Managers often infer, quite correctly, that many consumers do not like being asked to donate. Paradoxically, our results suggest this ostensibly negative experience can increase service repatronage. For academics, these results add to a growing body of literature refuting the notion that small prosocial acts affect behavior by altering an individual’s self-concept

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.

PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune response leading to durable remissions in a subset of cancer patients. Here, we describe an alternative mechanism of PD-L1 activity involving its secretion in tumor-derived exosomes. Removal of exosomal PD-L1 inhibits tumor growth, even in models resistant to anti-PD-L1 antibodies. Exosomal PD-L1 from the tumor suppresses T cell activation in the draining lymph node. Systemically introduced exosomal PD-L1 rescues growth of tumors unable to secrete their own. Exposure to exosomal PD-L1-deficient tumor cells suppresses growth of wild-type tumor cells injected at a distant site, simultaneously or months later. Anti-PD-L1 antibodies work additively, not redundantly, with exosomal PD-L1 blockade to suppress tumor growth. Together, these findings show that exosomal PD-L1 represents an unexplored therapeutic target, which could overcome resistance to current antibody approaches

U(2) and Maximal Mixing of nu_{mu}

A U(2) flavor symmetry can successfully describe the charged fermion masses and mixings, and supress SUSY FCNC processes, making it a viable candidate for a theory of flavor. We show that a direct application of this U(2) flavor symmetry automatically predicts a mixing of 45 degrees for nu_mu to nu_s, where nu_s is a light, right-handed state. The introduction of an additional flavor symmetry acting on the right-handed neutrinos makes the model phenomenologically viable, explaining the solar neutrino deficit as well as the atmospheric neutrino anomaly, while giving a potential hot dark matter candidate and retaining the theory's predictivity in the quark sector.Comment: 20 pages, 1 figur

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tregs) by exploiting their dependency on the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) in tumors. Disruption of EZH2 activity in Tregs, either pharmacologically or genetically, drove the acquisition of pro-inflammatory functions in TI-Tregs, remodeling the tumor microenvironment and enhancing the recruitment and function of CD8+ and CD4+ effector T cells that eliminate tumors. Moreover, abolishing EZH2 function in Tregs was mechanistically distinct from, more potent than, and less toxic than a generalized Treg depletion approach. This study reveals a strategy to target Tregs in cancer that mitigates autoimmunity by reprogramming their function in tumors to enhance anti-cancer immunity