Chronic fibrosing osteomyelitis of the jaws: an important cause of recalcitrant facial pain. A clinicopathologic study of 331 cases in 227 patients

Objective This was a retrospective and follow-up analysis of 331 cases of chronic fibrosing osteomyelitis of the jaws (CFOJ) in 227 patients. Study Design Demographic, clinical, surgical, and microscopic characteristics were tabulated for all patients. A follow-up mail survey was used to determine the degree of symptom relief experienced after surgery. Results The female to male ratio approached 7:1, and mean age of patients was 53 years. The most common sites were the mandibular posterior region, followed by the maxillary posterior region. Consistent clinical findings included intractable jaw pain mimicking that of odontogenic origin but unresponsive to usual therapies, minimal or undetectable radiographic abnormalities on plain films but dramatic radiolucencies detected on cone beam computed tomography, and large cavities that were either empty or filled with blood mixed with lipid globules encountered at surgery. The most common histomorphologic findings were vital lamellar bone, prominent resting and reversal lines, microshards and splaying of trabeculae, rounded trabeculae, marrow fibrosis, and pools of erythrocytes and lipid globules, often together. Moderate to complete relief of symptoms for periods up to 108 months after surgery were reported by 83% of the 70 patients who returned the survey. Conclusions On the basis of the findings of this study, CFOJ can be considered a unique entity with consistent clinicopathologic features. Its features suggest a pathogenesis based on bone marrow ischemia. CFOJ can be treated on a rational basis with a justifiable expectation of success and probable cure

Tower and Aircraft Eddy Covariance Measurements of Water Vapor, Energy, and Carbon Dioxide Fluxes during SMACEX

Abstract A network of eddy covariance (EC) and micrometeorological flux (METFLUX) stations over corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] canopies was established as part of the Soil Moisture–Atmosphere Coupling Experiment (SMACEX) in central Iowa during the summer of 2002 to measure fluxes of heat, water vapor, and carbon dioxide (CO2) during the growing season. Additionally, EC measurements of water vapor and CO2 fluxes from an aircraft platform complemented the tower-based measurements. Sensible heat, water vapor, and CO2 fluxes showed the greatest spatial and temporal variability during the early crop growth stage. Differences in all of the energy balance components were detectable between corn and soybean as well as within similar crops throughout the study period. Tower network–averaged fluxes of sensible heat, water vapor, and CO2 were observed to be in good agreement with area-averaged aircraft flux measurements

Measurement Of The Complex Nonlinear Refractive-Index Of Single-Crystal P-Toluene Sulfonate At 1064-Nm

Z-scan at 1064 nm was used with single, 35 ps pulses to measure the nonlinear refraction and absorption in single crystal PTS (p-toluene sulfonate). Detailed analysis of the Z-scan data based on DELTAn = n2I + n3I2 and DELTAalpha = alpha2I + alpha3I2 yielded n2 = 5(+/-1) X 10(-12) cm2/W, alpha2 = 100(+/-20) cm/GW, n3 = 5(+/-1)X 10(-21) cm4/W2 and alpha3 = - 5 (+/- 1) cm3/GW.2 The resulting two photon figure of merit T for PTS is marginal for high throughput, all-optical waveguide switching at 1064 nm

Mechanism of cholesterol gallstone dissolution. III. Electrophoretic studies showing the correlation between the bile micellarcharge and the effect of alkyl amines as cholesterol gallstone dissolution rate accelerators

We have shown that the cholesterol monohydrate dissolution rate acceleration in chenodeoxycholic acid solutions due to the addition of hexylamine and octylamine may be directly related to their ability to bind to the negatively charged chenodeoxycholate micelles. Based on these results, we have proposed that the primary mechanism by which these amines accelerate the dissolution rate is by reducing the micellar charge. An independent test of the above hypothesis was carried out by measuring the electrophoretic mobility of chenodeoxycholate micelles as a function of the amine concentration utilizing the moving boundary electrophoresis method in the presence of and absence of 0.1 M sodium chloride. At the concentrations of hexylamine and octylamine which gave the same dissolution rate, J/A, i.e., at equal efficacy, the electrophoretic mobilities were found to be the same. These results verify our hypothesis that the primary mechanism by which these amines accelerate the dissolution rate is by reducing the micellar charge. In addition, particle microelectrophoresis studies showed no significant surface charge variation with cholesterol particles as a function of amine concentration.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23303/1/0000241.pd

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load

: Two related ER oxidation 1 (ERO1) proteins, ERO1α and ERO1β, dynamically regulate the redox environment in the mammalian endoplasmic reticulum (ER). Redox changes in cysteine residues on intralumenal loops of calcium release and reuptake channels have been implicated in altered calcium release and reuptake. These findings led us to hypothesize that altered ERO1 activity may affect cardiac functions that are dependent on intracellular calcium flux. We established mouse lines with loss of function insertion mutations in Ero1l and Ero1lb encoding ERO1α and ERO1β. The peak amplitude of calcium transients in homozygous Ero1α mutant adult cardiomyocytes was reduced to 42.0 ± 2.2% (n=10, P ≤ 0.01) of values recorded in wild-type cardiomyocytes. Decreased ERO1 activity blunted cardiomyocyte inotropic response to adrenergic stimulation and sensitized mice to adrenergic blockade. Whereas all 12 wild-type mice survived challenge with 4 mg/kg esmolol, 6 of 8 compound Ero1l and Ero1lb mutant mice succumbed to this level of β adrenergic blockade (P ≤ 0.01). In addition, mice lacking ERO1α were partially protected against progressive heart failure in a transaortic constriction model [at 10 wk postprocedure, fractional shortening was 0.31 ± 0.02 in the mutant (n=20) vs. 0.23 ± 0.03 in the wild type (n=18); P ≤ 0.01]. These findings establish a role for ERO1 in calcium homeostasis and suggest that modifying the lumenal redox environment may affect the progression of heart failure

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).

ObjectiveTo evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.MethodsWe performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8.1 ± 2.1 days to either Drug treatment (n = 104) or Conservative management (n = 98). Drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).ResultsIndomethacin produced the greatest constriction (compared with spontaneous constriction during Conservative management): RR (95% CI) = 3.21 (2.05-5.01)), followed by ibuprofen = 2.03 (1.05-3.91), and acetaminophen = 1.33 (0.55-3.24). The initial rate of acetaminophen-induced constriction was 27%. Infants with persistent moderate-to-large PDA after acetaminophen were treated with indomethacin. The final rate of constriction after acetaminophen ± indomethacin was 60% (similar to the rate in infants receiving indomethacin-alone (62%)).ConclusionIndomethacin was more effective than acetaminophen in producing ductus constriction

A Liquid Crystal Biosensor for Specific Detection of Antigens

Following the principle of the enzyme-linked immunosorbent assay (ELISA) pathogen detection method, we demonstrate specific sensing of goat Immunoglobulin G (IgG) by a nematic liquid crystal material. Sensing occurs via the visually-striking realignment of a pre-fabricated liquid crystal film, suspended in grids and coated with biotinylated lipids followed by biotinylated anti-goat IgG. Realignment occurs when the targeted goat IgG is added to the cell, but not when rat or rabbit serum IgG is added to the same surface. In principle, this method can be generalized to provide an inexpensive, fast and sensitive prefabricated sensor for any pathogen

Communications Biophysics

Contains research objectives and summary of research.National Institutes of Health (Grant 5 PO1 GM14940-07)National Institutes of Health (Grant 1 RO1 NS11000-01)Clarence J. LeBel FundNational Institutes of Health (Grant 1 RO1 NS10737-01)National Aeronautics and Space Administration (Grant NGL 22-009-304)Boston City Hospital Purchase Order 1176-21335B-D Electrodyne Division, Becton Dickinson and Company (Grant)Chicago Musical Instrument Company (Grant