562 research outputs found
Knowledge, attitudes and practices towards evidence based practice::A survey amongst radiographers
Introduction: It is increasingly becoming a requirement for radiographers to use the concept of Evidence Based Practice (EBP) to inform their clinical practice. The purpose of this study was to assess knowledge, attitudes and practices towards the use of EBP as well as to establish factors that influence the use of EBP amongst radiographers in Uganda. Methods: A total of 83 respondents participated in a cross-sectional survey conducted amongst qualified radiographers licensed to practice in Uganda. Data was collected using a self-reporting questionnaire that was accessed through the Bristol Online Survey Software. Using SPSS version 21, descriptive and inferential statistics were generated. Results: The study revealed that 47 (57%) and 36 (43%) respondents scored themselves as having high and low knowledge of EBP respectively. However, 52 (63%) respondents scored themselves as having a negative attitude towards EBP. As regards use of EBP, 49 (59%) out of 83 respondents reported use of EBP in clinical practice. Using binary logistic regression, a significant association was found between a high knowledge level and the use of EBP (Adjusted OR, 95% CI: 9.89: 3.54–27.64). Conclusion: Overall, majority of the respondents had high knowledge levels about EBP. However, a high proportion of them were found to have a negative attitude towards EBP. High knowledge levels of EBP were strongly associated with use of EBP in practice. This finding provides helpful insights for policy makers to consider a holistic approach towards improving the use of EBP among radiographers through devising interventions that strengthen both knowledge and attitude towards EBP.</p
Observed Effect of Magnetic Fields on the Propagation of Magnetoacoustic Waves in the Lower Solar Atmosphere
We study Hinode/SOT-FG observations of intensity fluctuations in Ca II H-line
and G-band image sequences and their relation to simultaneous and co-spatial
magnetic field measurements. We explore the G-band and H-line intensity
oscillation spectra both separately and comparatively via their relative phase
differences, time delays and cross-coherences. In the non-magnetic situations,
both sets of fluctuations show strong oscillatory power in the 3 - 7 mHz band
centered at 4.5 mHz, but this is suppressed as magnetic field increases. A
relative phase analysis gives a time delay of H-line after G-band of 20\pm1 s
in non-magnetic situations implying a mean effective height difference of 140
km. The maximum coherence is at 4 - 7 mHz. Under strong magnetic influence the
measured delay time shrinks to 11 s with the peak coherence near 4 mHz. A
second coherence maximum appears between 7.5 - 10 mHz. Investigation of the
locations of this doubled-frequency coherence locates it in diffuse rings
outside photospheric magnetic structures. Some possible interpretations of
these results are offered.Comment: 19 pages, 6 figure
Larkin-Ovchinnikov-Fulde-Ferrell state in quasi-one-dimensional superconductors
The properties of a quasi-one-dimensional (quasi-1D) superconductor with {\it
an open Fermi surface} are expected to be unusual in a magnetic field. On the
one hand, the quasi-1D structure of the Fermi surface strongly favors the
formation of a non-uniform state (Larkin-Ovchinnikov-Fulde-Ferrell (LOFF)
state) in the presence of a magnetic field acting on the electron spins. On the
other hand, a magnetic field acting on an open Fermi surface induces a
dimensional crossover by confining the electronic wave-functions wave-functions
along the chains of highest conductivity, which results in a divergence of the
orbital critical field and in a stabilization at low temperature of a cascade
of superconducting phases separated by first order transistions. In this paper,
we study the phase diagram as a function of the anisotropy. We discuss in
details the experimental situation in the quasi-1D organic conductors of the
Bechgaard salts family and argue that they appear as good candidates for the
observation of the LOFF state, provided that their anisotropy is large enough.
Recent experiments on the organic quasi-1D superconductor (TMTSF)ClO
are in agreement with the results obtained in this paper and could be
interpreted as a signature of a high-field superconducting phase. We also point
out the possibility to observe a LOFF state in some quasi-2D organic
superconductors.Comment: 24 pages+17 figures (upon request), RevTex, ORSAY-LPS-24109
Multiscale magnetic underdense regions on the solar surface: Granular and Mesogranular scales
The Sun is a non-equilibrium dissipative system subjected to an energy flow
which originates in its core. Convective overshooting motions create
temperature and velocity structures which show a temporal and spatial
evolution. As a result, photospheric structures are generally considered to be
the direct manifestation of convective plasma motions. The plasma flows on the
photosphere govern the motion of single magnetic elements. These elements are
arranged in typical patterns which are observed as a variety of multiscale
magnetic patterns. High resolution magnetograms of quiet solar surface revealed
the presence of magnetic underdense regions in the solar photosphere, commonly
called voids, which may be considered a signature of the underlying convective
structure. The analysis of such patterns paves the way for the investigation of
all turbulent convective scales from granular to global. In order to address
the question of magnetic structures driven by turbulent convection at granular
and mesogranular scales we used a "voids" detection method. The computed voids
distribution shows an exponential behavior at scales between 2 and 10 Mm and
the absence of features at 5-10 Mm mesogranular scales. The absence of
preferred scales of organization in the 2-10 Mm range supports the multiscale
nature of flows on the solar surface and the absence of a mesogranular
convective scale
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A proposal for reducing maximum target doses of drugs for psychosis: Reviewing dose-response literature
YesBackground:
Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D2 receptor blockade required to treat psychosis. This may lead to excess harm through cognitive impairment and side effects.
Aims:
This analysis aimed to establish guidance for prescribers by optimally dosing drugs for psychosis based on efficacy and benefit.
Methods:
We used data from two dose–response meta-analyses and reviewed seven of the most prescribed drugs for psychosis in the UK. Where data were not available, we used appropriate comparison techniques based on D2 receptor occupancy to extrapolate our recommendations.
Results:
We found that the likely threshold dose for achieving remission of psychotic symptoms was often significantly below the currently licensed dose for these drugs. We therefore recommend that clinicians are cautious about exceeding our recommended doses. Individual factors, however, should be accounted for. We outline potentially relevant factors including age, ethnicity, sex, smoking status and pharmacogenetics. Additionally, we recommend therapeutic drug monitoring as a tool to determine individual pharmacokinetic variation.
Conclusions:
In summary, we propose a new set of maximum target doses for psychosis drugs based on efficacy. Further research through randomised controlled trials should be undertaken to evaluate the effect of reducing doses from current licensing maximums or from doses that are above our recommendations. However, dose reductions should be implemented in a manner that accounts for and reduces the effects of drug withdrawal
Recommended from our members
A proposal for reducing maximum target doses of drugs for psychosis: Reviewing dose–response literature
Background:
Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D2 receptor blockade required to treat psychosis. This may lead to excess harm through cognitive impairment and side effects.
Aims:
This analysis aimed to establish guidance for prescribers by optimally dosing drugs for psychosis based on efficacy and benefit.
Methods:
We used data from two dose–response meta-analyses and reviewed seven of the most prescribed drugs for psychosis in the UK. Where data were not available, we used appropriate comparison techniques based on D2 receptor occupancy to extrapolate our recommendations.
Results:
We found that the likely threshold dose for achieving remission of psychotic symptoms was often significantly below the currently licensed dose for these drugs. We therefore recommend that clinicians are cautious about exceeding our recommended doses. Individual factors, however, should be accounted for. We outline potentially relevant factors including age, ethnicity, sex, smoking status and pharmacogenetics. Additionally, we recommend therapeutic drug monitoring as a tool to determine individual pharmacokinetic variation.
Conclusions:
In summary, we propose a new set of maximum target doses for psychosis drugs based on efficacy. Further research through randomised controlled trials should be undertaken to evaluate the effect of reducing doses from current licensing maximums or from doses that are above our recommendations. However, dose reductions should be implemented in a manner that accounts for and reduces the effects of drug withdrawal
Fractional vortices on grain boundaries --- the case for broken time reversal symmetry in high temperature superconductors
We discuss the problem of broken time reversal symmetry near grain boundaries
in a d-wave superconductor based on a Ginzburg-Landau theory. It is shown that
such a state can lead to fractional vortices on the grain boundary. Both
analytical and numerical results show the structure of this type of state.Comment: 9 pages, RevTeX, 5 postscript figures include
Quantitative predictions on auxin-induced polar distribution of PIN proteins during vein formation in leaves
The dynamic patterning of the plant hormone auxin and its efflux facilitator
the PIN protein are the key regulator for the spatial and temporal organization
of plant development. In particular auxin induces the polar localization of its
own efflux facilitator. Due to this positive feedback auxin flow is directed
and patterns of auxin and PIN arise. During the earliest stage of vein
initiation in leaves auxin accumulates in a single cell in a rim of epidermal
cells from which it flows into the ground meristem tissue of the leaf blade.
There the localized auxin supply yields the successive polarization of PIN
distribution along a strand of cells. We model the auxin and PIN dynamics
within cells with a minimal canalization model. Solving the model analytically
we uncover an excitable polarization front that triggers a polar distribution
of PIN proteins in cells. As polarization fronts may extend to opposing
directions from their initiation site we suggest a possible resolution to the
puzzling occurrence of bipolar cells, such we offer an explanation for the
development of closed, looped veins. Employing non-linear analysis we identify
the role of the contributing microscopic processes during polarization.
Furthermore, we deduce quantitative predictions on polarization fronts
establishing a route to determine the up to now largely unknown kinetic rates
of auxin and PIN dynamics.Comment: 9 pages, 4 figures, supplemental information included, accepted for
publication in Eur. Phys. J.
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