Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study

Introduction: Acne is a multifactorial and common skin disease which can significantly affect the quality of life of sufferers. In this study, a topical herbal preparation traditionally used in Ayurvedic medicine was evaluated as a treatment for individuals with acne on their shoulders and backs. Methods: Study participants were randomly assigned either to treatment (Eladi Keram) or vehicle control (coconut oil) groups under double blind conditions and instructed on its daily home application. Standardised lesion counting and acne grading were conducted in accordance with US Food and Drug Administration guidelines and with reference to the Leeds Acne Grading Technique. Participants were assessed for severity of the condition at commencement and on day 28 of treatment. Results: The treatment group showed improvements of 42% (p < 0.005) on the Investigators Global Assessment scale, a 60% (p < 0.05) reduction in inflammatory lesions, a 59% (p < 0.05) reduction in non-inflammatory lesions, and a 59% (p < 0.005) reduction in combined lesion count. The control group showed no statistically significant changes for these criteria. Conclusion: This study is the first reported clinical evaluation of Eladi Keram as a treatment for acne and findings suggest that it could be effective in reducing inflammatory and non-inflammatory lesions, warranting further investigation by means of a larger scale clinical trial

Neutron stars and strange stars in the chiral SU(3) quark mean field model

We investigate the equations of state for pure neutron matter and strange hadronic matter in $\beta$-equilibrium, including $\Lambda$, $\Sigma$ and $\Xi$ hyperons. The masses and radii of pure neutron stars and strange hadronic stars are obtained. For a pure neutron star, the maximum mass is about $1.8 M_{\mathrm{sun}}$, while for a strange hadronic star, the maximum mass is around $1.45 M_{\mathrm{sun}}$. The typical radii of pure neutron stars and strange hadronic stars are about 11.0-12.3 km and 10.7-11.7 km, respectively.Comment: 18 pages, 7 figure

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes

Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001–CVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001–CVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001–CVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD

A Study of Human Serum Sickness

Twelve patients with bone marrow failure, who were undergoing therapy with daily intravenous infusions of horse antithymocyte globulin, were studied for the development of serum sickness. Eleven of 12 patients developed typical signs and symptoms of serum sickness 8-13 days after the initiation of treatment. These included fever, malaise, cutaneous eruptions, arthralgias, gastrointestinal disturbances, and lymphadenopathy. Eleven of 12 patients developed high levels of circulating immune complexes during serum sickness. All 12 patients also had concomitant decreases of serum C3 and C4 levels. In addition to urticarial and/or morbilliform eruptions, 8 of 11 patients also developed a serpiginous band of erythema along the sides of the fingers, hands, toes, or feet as an early cutaneous sign of serum sickness. Direct immunofluorescence of lesional skin biopsies during serum sickness revealed deposits of immunoglobulin or complement in the walls of small cutaneous blood vessels in 3 of 5 patients. These findings indicate that circulating immune complexes play a central role in the pathophysiology of human serum sickness

Effect of isovector-scalar meson on neutron star matter in strong magnetic fields

We study the effects of isovector-scalar meson $\delta$ on the equation of state (EOS) of neutron star matter in strong magnetic fields. The EOS of neutron-star matter and nucleon effective masses are calculated in the framework of Lagrangian field theory, which is solved within the mean-field approximation. From the numerical results one can find that the $\delta$-field leads to a remarkable splitting of proton and neutron effective masses. The strength of $\delta$-field decreases with the increasing of the magnetic field and is little at ultrastrong field. The proton effective mass is highly influenced by magnetic fields, while the effect of magnetic fields on the neutron effective mass is negligible. The EOS turns out to be stiffer at $B < 10^{15}$G but becomes softer at stronger magnetic field after including the $\delta$-field. The AMM terms can affect the system merely at ultrastrong magnetic field($B > 10^{19}$G). In the range of $10^{15}$ G -- $10^{18}$ G the properties of neutron-star matter are found to be similar with those without magnetic fields.Comment: 26 pages, 9 figure

Site-based and remote sensing methods for monitoring indicators of vegetation condition: An Australian review

Native vegetation around the world is under threat from historical and ongoing clearance, overgrazing, invasive species, increasing soil and water salinity, altered fire regimes, poor land management and other factors, resulting in a degradation of natural ecosystem services. Consequently, maintaining and improving native vegetation condition is a target frequently adopted by natural resource managers and government agencies world-wide. Adequate monitoring of vegetation condition remains a prerequisite for environmental decision-making and for tracking progress towards management goals. Throughout we consider vegetation condition to include the compositional, structural and functional attributes of vegetation relative to undisturbed vegetation of the same type. Site-based methods have long been used to assess compositional, structural and functional attributes as indicators of vegetation condition, and these methods continue to be used widely today. With developing technologies, remote sensing methods are being employed increasingly for monitoring a range of remotely detectable properties of vegetation, and there is now a growing demand to explicitly integrate the two approaches for mapping and monitoring vegetation condition across a range of scales. Here we review the attributes of vegetation identified as important for monitoring vegetation condition, those indicators that are best measured using traditional site-based methods and those that are more readily detectable using remote sensing methods, including their application in operational programmes within Australia. Further to this we review recent literature on the integration of the two approaches for monitoring indicators of vegetation condition. We find that remote sensing methods have the advantage of offering broad scale automated and repeatable methods for monitoring indicators of vegetation condition, but when combined with detailed ecological site-based data, together can improve monitoring for answering ecological questions across a range of scales. Further work, however, is required to effectively integrate the two approaches for mapping and monitoring vegetation condition

Heart valve prostheses in pregnancy: Outcomes for women and their babies

Background: As the prognosis of women with prosthetic heart valves improves more of these individuals are contemplating and undertaking pregnancy. Accurate knowledge of perinatal outcomes is essential, assisting counselling and guiding care. The aim of this study was to assess outcomes in a contemporary population of women with heart valve prostheses undertaking pregnancy, and to compare outcomes for women with mechanical and bioprosthetic prostheses. Method and results: Longitudinally-linked population health datasets containing birth and hospital admissions data were obtained for all women giving birth in New South Wales, Australia, 2000-2011. This included information identifying presence of maternal prosthetic heart valve. Cardiovascular and birth outcomes were evaluated. Among 1 144 156 pregnancies, 136 involved women with a heart valve prosthesis (1 in 10 000). No maternal mortality was seen among these women, although the relative risk for an adverse event was higher than the general population, including severe maternal morbidity (13.9% v. 1.4%, RR=9.96, 95% CI 6.32-15.7), major maternal cardiovascular event (4.4% v. 0.1%, RR 34.6, 95% CI 14.6-81.6), preterm birth (18.3% v. 6.6%, RR=2.77, 95% CI 1.88-4.07) and small-for-gestational-age infants (19.3% v. 9.5%, RR=2.12, 95% CI 1.47-3.06). There was a trend towards increased maternal and perinatal morbidity in women with a mechanical valve compared to bioprosthetic. Conclusions: Pregnancies in women with a prosthetic heart valve demonstrate an increased risk of an adverse outcome, for both mothers and babies, compared with pregnancies in the absence of heart valve prostheses. In this contemporary population, the risk was lower than previously reported.NHMRC 1001066, NHMRC 1021025, NHMRC 1062262, ARC FT120100069, Australian Heart Foundatio