On the Klein-Gordon equation and hyperbolic pseudoanalytic function theory

Elliptic pseudoanalytic function theory was considered independently by Bers and Vekua decades ago. In this paper we develop a hyperbolic analogue of pseudoanalytic function theory using the algebra of hyperbolic numbers. We consider the Klein-Gordon equation with a potential. With the aid of one particular solution we factorize the Klein-Gordon operator in terms of two Vekua-type operators. We show that real parts of the solutions of one of these Vekua-type operators are solutions of the considered Klein-Gordon equation. Using hyperbolic pseudoanalytic function theory, we then obtain explicit construction of infinite systems of solutions of the Klein-Gordon equation with potential. Finally, we give some examples of application of the proposed procedure

Search for chameleons with CAST

In this work we present a search for (solar) chameleons with the CERN Axion Solar Telescope (CAST). This novel experimental technique, in the field of dark energy research, exploits both the chameleon coupling to matter ($\beta_{\rm m}$) and to photons ($\beta_{\gamma}$) via the Primakoff effect. By reducing the X-ray detection energy threshold used for axions from 1$\,$keV to 400$\,$eV CAST became sensitive to the converted solar chameleon spectrum which peaks around 600$\,$eV. Even though we have not observed any excess above background, we can provide a 95% C.L. limit for the coupling strength of chameleons to photons of $\beta_{\gamma}\!\lesssim\!10^{11}$ for $1<\beta_{\rm m}<10^6$.Comment: 8 pages, 12 figure

Метод криоплазмосорбции в комплексном лечении больных распространенным перитонитом

The dissatisfaction of patients having generalized peritonitis with the results of treatment and high mortality rates have induced the authors to optimize treatment policy, by introducing the cryoplasmasorption technique aimed at correcting endogenous intoxication.Subjects and methods. The study covered 67 patients with generalized peritonitis, including 29 and 38 patients having its toxic and terminal stages, respectively. According to the therapy performed, the patients were divided into 2 groups: 1) 39 received cryoplasmasorption and 2) 28 had conventional therapy. The efficiency of treatment was evaluated by the changes in a battery of clinical laboratory data including hemostasis, immunity, and intoxication indices.Results. Cryoplasmasorption was shown to have a positive impact on the homeostatic parameters under study, which could reduce mortality rates in patients with generalized peritonitis by 14%. Неудовлетворенность результатами лечения больных распространенным перитонитом и высокая летальность побудили нас оптимизировать лечебную тактику путем внедрения метода криоплазмосорбции, направленного на коррекцию эндогенной интоксикации.Материалы и методы. В исследование включили 67 больных распространенным перитонитом, течение заболевания у 29 из них соответствовало токсической, у 38 — терминальной стадиям. В зависимости от проводимой интенсивной терапии больные были разделены на группы: в I группе (39 человек) проводили криоплаз-мосорбцию, во II (28человек) — традиционную терапию. Эффективность проводимого лечения оценивали на основании динамики комплекса клинико-лабораторных данных, включающих гемостаз, иммунный статус, показатели интоксикации.Результаты исследования показали, что метод криоплазмосорбции благоприятно воздействует на изучаемые показатели гомеостаза, что позволило снизить летальность больных распространенным перитонитом на 14%.

Development of recurrent coastal plume in Lake Michigan observed for first time

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94637/1/eost11132.pd

Экстракорпоральные методы детоксикации при распространенном перитоните

Objective: to optimize the results of treatment in patients with generalized peritonitis. Sixty-eight patients were examined. In Group 1 (n=26), plasmapheresis was performed during traditional therapy; in Group 2 (n=28) plasmapheresis was combined with extracorporeal antibiotic therapy; and Group 3 (n=12) received only traditional therapy (a control group). The parameters of hemostasis, endotoxemia, and immunity were studied over time. The early use of these methods improved hemostatic parameters and mortality rates. Key words: generalized peritonitis, plasmapheresis, extracor-poreal pharmacotherapy.Цель исследования . Оптимизировать результаты лечения больных распространенным перитонитом. Обследовано 68 больных. В 1-й группе (у 26 больных) проводили плазмаферез на фоне традиционной терапии, во 2-й (у 28 человек) — плазмаферез в сочетании с экстракорпоральной фармакотерапией антибиотиком, в 3-й (у 12 больных) — только традиционную терапию — контрольная группа. В динамике изучали показатели гемостаза, эндотоксемии, иммунитета. Показано улучшение показателей гомеостаза и снижение уровня летальности при раннем применении этих методов. Ключевые слова: распространенный перитонит, плазмаферез, экстракорпоральная фармакотерапия

Performance of the LHCb outer tracker

The LHCb Outer Tracker is a gaseous detector covering an area of 5 × 6 m2 with 12 double layers of straw tubes. The detector with its services are described together with the commissioning and calibration procedures. Based on data of the first LHC running period from 2010 to 2012, the performance of the readout electronics and the single hit resolution and efficiency are presented. The efficiency to detect a hit in the central half of the straw is estimated to be 99.2%, and the position resolution is determined to be approximately 200 μm. The Outer Tracker received a dose in the hottest region corresponding to 0.12 C/cm, and no signs of gain deterioration or other ageing effects are observed

Anatomy of the recurrent coastal sediment plume in Lake Michigan and its impacts on light climate, nutrients, and plankton

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94624/1/jgrc9664.pd

Grape-Derived Polyphenols Improve Aging-Related Endothelial Dysfunction in Rat Mesenteric Artery: Role of Oxidative Stress and the Angiotensin System

Aging is characterized by the development of an endothelial dysfunction, which affects both the nitric oxide (NO)- and the endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations, associated with vascular oxidative stress and the activation of the angiotensin system. This study investigated whether red wine polyphenols (RWPs), antioxidants and potent stimulators of NO- and EDHF-mediated relaxations improve aging-related endothelial dysfunction, and, if so, examined the underlying mechanism. Mesenteric artery reactivity was determined in organ chambers, vascular oxidative stress by dihydroethidine and MitoSOX staining, and expression of target proteins by immunohistochemical staining. Control young rats (16 weeks) received solvent (ethanol, 3% v/v), and middle-aged rats (46 weeks) either solvent or RWPs (100 mg/kg/day) in the drinking water. The acetylcholine-induced endothelium-dependent NO component was slightly reduced whereas the EDHF component was markedly blunted in rings of middle-aged rats compared to young rats. The endothelial dysfunction was associated with oxidative stress, an upregulation of angiotensin II and AT1 receptors and a down-regulation of SKCa, IKCa, and angiotensin converting enzyme. Intake of RWPs for either one or two weeks improved the NO and the EDHF components of the relaxation, and normalized oxidative stress, the expression of SKCa, IKCa and the components of the angiotensin system. The protective effect of the 2-week RWPs treatment persisted for one and two weeks following stopping intake of RWPs. Thus, intake of RWPs caused a persistent improvement of the endothelial function, particularly the EDHF component, in middle-aged rats and this effect seems to involve the normalization of the expression of SKCa, IKCa and the angiotensin system

The CPT1C 5′UTR Contains a Repressing Upstream Open Reading Frame That Is Regulated by Cellular Energy Availability and AMPK

BACKGROUND: Translational control is utilized as a means of regulating gene expression in many species. In most cases, posttranscriptional regulatory mechanisms play an important role in stress response pathways and can lead to dysfunctional physiology if blocked by mutations. Carnitine Palmitoyltransferase 1 C (CPT1C), the brain-specific member of the CPT 1 family, has previously been shown to be involved in regulating metabolism in situations of energy surplus. PRINCIPAL FINDINGS: Sequence analysis of the CPT1C mRNA revealed that it contains an upstream open reading frame (uORF) in the 5' UTR of its mRNA. Using CPT1C 5' UTR/luciferase constructs, we investigated the role of the uORF in translational regulation. The results presented here show that translation from the CPT1C main open reading frame (mORF) is repressed by the presence of the uORF, that this repression is relieved in response to specific stress stimuli, namely glucose deprivation and palmitate-BSA treatment, and that AMPK inhibition can relieve this uORF-dependent repression. SIGNIFICANCE: The fact that the mORF regulation is relieved in response to a specific set of stress stimuli rather than general stress response, hints at an involvement of CPT1C in cellular energy-sensing pathways and provides further evidence for a role of CPT1C in hypothalamic regulation of energy homeostasis