Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation

The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly mediates these effects by modulating gene expression. During transcriptional regulation, the AR recruits numerous cofactors with acetylation-modifying enzymatic activity, the best studied include p300/CBP and the p160/SRC family of coactivators. It is known that recruitment of histone acetyltransferases (HATs) and histone deacetylases (HDACs) is key in fine-tuning responses to androgens and is thus likely to play a role in prostate cancer progression. Further, these proteins can also modify the AR itself. The functional consequences of AR acetylation, the role of modifying enzymes in relation to AR transcriptional response, and prostate cancer will be discussed

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Acknowledgements This work was supported by funding from the Chief Scientist Office, Government of Scotland (Grant Nos CZB/4/477 and ETM/258). DNL was supported by the Association for International Cancer Research (Grant No. 03–127)Peer reviewedPublisher PD

Observations of broadband acoustic backscattering from nonlinear internal waves : assessing the contribution from microstructure

Author Posting. © IEEE, 2010. This article is posted here by permission of IEEE for personal use, not for redistribution. The definitive version was published in IEEE Journal of Oceanic Engineering 35 (2010): 695-709, doi:10.1109/JOE.2010.2047814.In this paper, measurements of high-frequency broadband (160-590 kHz) acoustic backscattering from surface trapped nonlinear internal waves of depression are presented. These waves are ideal for assessing the contribution from oceanic microstructure to scattering as they are intensely turbulent. Almost coincident direct microstructure measurements were performed and zooplankton community structure was characterized using depth-resolved net sampling techniques. The contribution to scattering from microstructure can be difficult to distinguish from the contribution to scattering from zooplankton using a single narrowband frequency as microstructure and zooplankton are often colocated and can have similar scattering levels over a range of frequencies. Yet their spectra are distinct over a sufficiently broad frequency range, allowing broadband backscattering measurements to reduce the ambiguities typically associated with the interpretation of narrowband measurements. In addition, pulse compression signal processing techniques result in very high-resolution images, allowing physical processes that are otherwise hard to resolve to be imaged, such as Kelvin-Helmholtz shear instabilities. In this study, high-resolution acoustic observations of multiple nonlinear internal waves are presented and regions with distinct scattering spectra are identified. Spectra that decrease in level across the available frequency band were highly correlated to regions of intense turbulence and high stratification, and to Kevin-Helmholtz shear instabilities in particular. Spectra that increase in level across the available frequency band were consistent with scattering dominated by small zooplankton. Simple inversions for relevant microstructure parameters are presented. Limitations of, and improvements to, the broadband system and techniques utilized in this study are discussed.This work was supported in part by the Woods Hole Oceanographic Institution and the U.S. Office of Naval Research under Grant N000140210359

Nosepiece respiration monitor

Comfortable, inexpensive nosepiece respiration monitor produces rapid response signals to most conventional high impedance medical signal conditioners. The monitor measures respiration in a manner that produces a large signal with minimum delay

The Orbital Angular Momentum of Light for Ultra-High Capacity Data Centers

The potential of orbital angular momentum (OAM) of light in data center scenarios is presented. OAMs can be exploited for short reach ultra-high bit rate fiber links and as additional multiplexing domain in transparent ultra-high capacity optical switches. Recent advances on OAM integrated photonic technology are also reported. Finally demonstration of OAM-based fiber links (aggregate throughput 17.9 Tb/s) and two layers OAM-WDM-based optical switches are presented exploiting OAM integrated components and demonstrating the achievable benefits in terms of size, weight and power consumption (SWaP) compared to different technologies

Laser processing of bulk metallic glass: A review

The emergence of bulk metallic glasses and their identification as versatile advanced engineering materials with attractive properties has led to a surge in research efforts to investigate processing methods, which can be used either to synthesise new BMG alloys or to shape BMG workpieces into final components with specific geometries. Among such technologies, the number of studies focussing on the laser processing of BMGs has gradually increased over the past decade. For this reason, a comprehensive summary of the state-of-the-art in this particular field of research is presented in this review. The reported studies are categorised into the different laser applications that have been proposed so far by the research community, namely the welding, cladding, additive layer manufacturing, micro machining and microstructure modification of BMG substrates. Due to the attractive properties of BMGs stemming from their amorphous nature, results are also presented, when available, concerning the effect of laser irradiation on the generation of crystalline precipitates during processing and the effect of these changes on the resulting material properties. This review has identified a number of gaps in the knowledge surrounding the laser processing of bulk metallic glasses. Understanding the fundamental interaction of laser energy with multi-component alloys will be necessary, as the development of lasers continues and the amount of available bulk metallic glasses increases. In particular, the crystallisation kinetics of bulk metallic glasses during laser irradiation needs to be understood to aid in the development and optimisation of processes such as welding and cladding. This could be helped by created an accurate simulation model to predict the onset of crystallisation although this is not a minor challenge, developing a complete temperature field model during laser irradiation is a complex task when considering vaporisation, plasma effects as well as chemical composition changes in the material. Besides, there is also the issue of variations in material properties as the temperature increases, particularly for BMGs whose temperature dependent properties are not well-documented. The research into the additive layer manufacturing of bulk metallic glass should continue to grow. Parametric effects need to be addressed to complete the optimisation of this process. Further investigations of the resulting crystallisation processes upon repeated melting and solidification should also aid in the process being able to be controlled more effectively. Finally, the use of laser processing of bulk metallic glass for specific application needs to be investigated further

Probing the Evolution of the Galaxy Interaction/Merger Rate Using Collisional Ring Galaxies

We present the results from our program to determine the evolution of the galaxy interaction/merger rate with redshift using the unique star-forming characteristics of collisional ring galaxies. We have identified 25 distant collisional ring galaxy candidates (CRGCs) in a total of 162 deep Hubble Space Telescope Wide Field/Planetary Camera-2 images obtained from the HST Archives. Based on measured and estimated redshifts, these 25 CRGCs all lie in the redshift interval of 0.1 < z < 1. Using the local collisional ring galaxy volume density and the new ``standard'' cosmology, we find that in order to account for the number of identified CRGCs in our surveyed fields, the galaxy interaction/merger rate, parameterized as (1 + z)^m, must increase steeply with redshift.We determine a minimum value of m = 5.2 $\pm$ 0.7, though m could be as high as 7 or 8. We can rule out a non-evolving (m = 0) and weakly evolving (m = 1-2) galaxy interaction/merger rate at greater than the 4 sigma level of confidence.Comment: Accepted in the Astrophysical Journal (11 pages, 4 figures). Higher resolution version of the figures is available at http://www.astro.cornell.edu/~vassilis/papers

High-dimensional quantum cryptography with twisted light

Quantum key distributions (QKD) systems often rely on polarization of light for encoding, thus limiting the amount of information that can be sent per photon and placing tight bounds on the error that such a system can tolerate. Here we describe a proof-of-principle experiment that indicates the feasibility of high-dimensional QKD based on the transverse structure of the light field, allowing for the transfer of more than 1 bit per photon. Our implementation uses the orbital angular momentum (OAM) of photons and the corresponding mutually unbiased basis of angular position (ANG). Our experiment uses a digital micro-mirror device for the rapid generation of OAM and ANG modes at 4 kHz, and a mode sorter capable of sorting single photons based on their OAM and ANG content with a separation efficiency of 93\%. Through the use of a 7-dimensional alphabet encoded in the OAM and ANG bases, we achieve a channel capacity of 2.05 bits per sifted photon. Our experiment shows that, in addition to having an increased information capacity, QKD systems based on spatial-mode encoding will be more tolerant to errors and thus more robust against eavesdropping attacks