Experiences of Looping for Students with Learning Disabilities: A Phenomenological Case Study

The problem is the academic, social, and emotional needs of students with learning disabilities are not being met within the general classroom. Looping, the practice of a teacher staying with the same group of students for two or more years, has been suggested as an educational approach designed to meet the needs of students with disabilities. The purpose of this research project was to examine the experiences of looping for students with learning disabilities from the perspectives of the looping teacher, the students with learning disabilities, and their parents. Therefore, a phenomenological case study design was utilized. The methods of data collection included teacher and student interviews, a parental questionnaire, examination of student artifacts, and observations of everyday school activities. Examination of the research data revealed no significant improvement in the academic or speech performances of the students with learning disabilities; yet, their social skills and emotional competencies improved

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L

Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of. They associate with a large and diverse set of coregulators termed cochaperones that regulate their function and specificity. Amongst others, chaperones and cochaperones regulate the activity of several signaling molecules including steroid receptors, which upon ligand binding interact with discrete nucleotide sequences within the nucleus to control the expression of diverse physiological and developmental genes. Molecular chaperones and cochaperones are typically known to provide the correct conformation for ligand binding by the steroid receptors. While this contribution is widely accepted, recent studies have reported that they further modulate steroid receptor action outside ligand binding. They are thought to contribute to receptor turnover, transport of the receptor to different subcellular localizations, recycling of the receptor on chromatin and even stabilization of the DNA-binding properties of the receptor. In addition to these combined effects with molecular chaperones, cochaperones are reported to have additional functions that are independent of molecular chaperones. Some of these functions also impact on steroid receptor action. Two well-studied examples are the cochaperones p23 and Bag-1L, which have been identified as modulators of steroid receptor activity in nuclei. Understanding details of their regulatory action will provide new therapeutic opportunities of controlling steroid receptor action independent of the widespread effects of molecular chaperones

Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver Nanoparticles Released from Medical Devices

Silver nanoparticles (AgNP) are incorporated into medical devices for their anti-microbial characteristics. The potential exposure and toxicity of AgNPs is unknown due to varying physicochemical particle properties and lack of toxicological data. The aim of this safety assessment is to derive a provisional tolerable intake (pTI) value for AgNPs released from blood-contacting medical devices. A literature review of in vivo studies investigating critical health effects induced from intravenous (i. v.) exposure to AgNPs was evaluated by the Annapolis Accords principles and Toxicological Data Reliability Assessment Tool (ToxRTool). The point of departure (POD) was based on an i. v. 28-day repeated AgNP (20 nm) dose toxicity study reporting an increase in relative spleen weight in rats with a 5% lower confidence bound of the benchmark dose (BMDL05) of 0.14 mg/kg bw/day. The POD was extrapolated to humans by a modifying factor of 1,000 to account for intraspecies variability, interspecies differences and lack of long-term toxicity data. The pTI for long-term i. v. exposure to 20 nm AgNPs released from blood-contacting medical devices was 0.14 μg/kg bw/day. This pTI may not be appropriate for nanoparticles of other physicochemical properties or routes of administration. The methodology is appropriate for deriving pTIs for nanoparticles in general

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease

It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease. In this study we sought to characterize the relationship between demyelination, inflammation and axonal transport changes using a Plp1-transgenic mouse model of Pelizaeus-Merzbacher disease. In the optic pathway of this non-immune mediated model of demyelination, myelin loss progresses from the optic nerve head towards the brain, over a period of months. Axonal transport is functionally perturbed at sites associated with local inflammation and 'damaged' myelin. Surprisingly, where demyelination is complete, naked axons appear well preserved despite a significant reduction of axonal transport. Our results suggest that neuroinflammation and/or oligodendrocyte dysfunction are more deleterious for axonal health than demyelination per se, at least in the short ter

The Black Hole Mass of NGC 4151. II. Stellar Dynamical Measurement from Near-Infrared Integral Field Spectroscopy

We present a revised measurement of the mass of the central black hole (Mbh) in the Seyfert 1 galaxy NGC 4151. The new stellar dynamical mass measurement is derived by applying an axisymmetric orbit-superposition code to near-infrared integral field data obtained using adaptive optics with the Gemini NIFS spectrograph. When our models attempt to fit both the NIFS kinematics and additional low spatial resolution kinematics, our results depend sensitively on how chi-squared is computed--probably a consequence of complex bar kinematics that manifest immediately outside the nuclear region. The most robust results are obtained when only the high spatial resolution kinematic constraints in the nuclear region are included in the fit. Our best estimates for the BH mass and H-band mass-to-light ratio are Mbh~(3.76+/-1.15)E7 Msun (1-sigma error) and M/L(H-band)~0.34+/-0.03 Msun/Lsun (3-sigma error), respectively (the quoted errors reflect the model uncertainties). Our BH mass measurement is consistent with estimates from both reverberation mapping (3.57[+0.45/-0.37]E7 Msun) and gas kinematics (3.0[+0.75/-2.2]E7 Msun; 1-sigma errors), and our best-fit mass-to-light ratio is consistent with the photometric estimate of M/L(H-band)=0.4+/-0.2 Msun/Lsun. The NIFS kinematics give a central bulge velocity dispersion sigma_c=116+/-3 km/s, bringing this object slightly closer to the M-sigma relation for quiescent galaxies. Although NGC 4151 is one of only a few Seyfert 1 galaxies in which it is possible to obtain a direct dynamical BH mass measurement--and thus, an independent calibration of the reverberation mapping mass scale--the complex bar kinematics makes it less than ideally suited for this purpose.Comment: 21 pages, 15 figures. Accepted for publication in Ap

Work in Progress: The RICA Project: Rich, Immediate Critique of Antipatterns in Student Code

Rich, relevant, and immediate student feedback is a core ingredient supporting effective student learning. Feedback is particularly important for introductory computing courses where novice programmers are still learning the basic syntax and semantics of a programming language. Our project is aimed at detecting poor solutions to common problems, termed antipatterns, in student code and providing feedback that guides the student to better solutions. This paper discusses the first year of the project, specifically, the development of a Code Critiquer to detect antipatterns in student code and generate appropriate feedback. This important first step sets-up the project to advance knowledge about novice antipatterns and their detection. The use of these antipatterns and code critiquers in future classroom interventions will help the project improve our understanding of student learning, retention, and self-efficacy

Perceptions, priorities, and project delivery problems in women's and environmental health in Peru: a qualitative study.

BACKGROUND: Women living in low-income and-middle-income countries experience increased exposure and worse effects of environmental threats and climate change. Peru is especially susceptible to a range of environmental exposures, including high levels of pollutants, contamination associated with extractive industries, and flooding exacerbated by the ongoing climate emergency. International policies and movements are increasingly calling for a gendered approach to planetary health. However, little research has been done explicitly examining environmental threats to women's health in Peru. We aimed to understand the current Peruvian research, advocacy, and policy landscape at the environment-gender health nexus. METHODS: We did in-depth semi-structured interviews in Spanish via online Zoom video conferencing (audio only) with key informants from the Peruvian Government, academia, and non-governmental organisations to explore their perception of environmental health threats and priorities, population vulnerability factors, awareness of projects and collaborations on these topics, and the role of gender in their work. We used thematic analysis to compare priorities, gender sensitivity, and barriers and facilitators to delivering successful women's environmental health projects in the country. FINDINGS: Since July 14, 2020, we have interviewed 16 people, with four further interviews planned to take place before the end of May, 2021. Several interviewees mentioned the detrimental role of weak institutions, multilevel corruption, and the absence of interdisciplinarity and intersectorality across programmes and research. Barriers to successful collaboration across organisations and sectors were clearly identified, including funding scandals related to extractive economies, high staff turnovers impairing long-term programme implementation, and machismo culture in both organisations and communities. By contrast, some interviewees highlighted that successful collaborations were instead built on direct relationships, reputation, trust, and transparency. Women's empowerment was also described as important for successful programme delivery, especially in female-led associations. Some interviewees emphasised the so-called invisibilisation of vulnerable groups, such as girls, teenagers, pregnant women, victims of gender-based violence, and LGBTQI people. Existing health inequalities varied by setting and cultural context and were deeply and silently exacerbated by the COVID-19 pandemic. INTERPRETATION: These qualitative findings highlight the multiple and inter-related contextual issues faced by environmentally threatened communities in Peru, and how macrostructural barriers contribute to a paucity of sustainable, gender-oriented, environmental health projects. FUNDING: Partially funded by the UK's Economic and Social Research Council

Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat

Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n = 8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03; P < .05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease

Supporting well-being in retirement through meaningful social roles: Systematic review of intervention studies

Context The marked demographic change toward greater proportions of older people in developed nations poses significant challenges for health and social care. Several studies have demonstrated an association between social roles in later life and positive health and well-being outcomes. After retiring from work, people may lose roles that provide purpose and social contacts. The outcomes of interventions to promote social roles in retirement have not been systematically reviewed. Methods We examined three research questions: (1) What kinds of intervention have been developed to promote social roles in retirement? (2) How much have they improved perceived roles? (3) Have these roles improved health or well-being? We included those studies that evaluated the provision of social roles; used a control or comparison group; targeted healthy retirement-transition adults who were living in the community; provided an abstract written in English; took place in a highly developed nation; and reported social role, health, or well-being outcomes. We searched eight electronic databases and combined the results with hand searches. Findings Through our searches, we identified 9,062 unique publications and eleven evaluative studies of acceptable quality, which reported seven interventions that met our inclusion criteria. These interventions varied in year of inception and scope, but only two were based outside North America. The studies rarely reported the quality or meaning of roles. Only three studies used random allocation, thus limiting inferences of causality from these studies. Interventions providing explicit roles and using supportive group structures were somewhat effective in improving one or more of the following: life satisfaction, social support and activity, physical health and activity, functional health, and cognition. Conclusions Social role interventions may improve health and well-being for people in retirement transition. Future research should improve the quality of intervention and assessment and look at which interventions are most effective and acceptable in facilitating social roles for diverse older populations. © 2013 Milbank Memorial Fund