3,518 research outputs found

    The Metric of Yang-Mills Orbit Space on the Lattice

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    We find coordinates, the metric tensor, the inverse metric tensor and the Laplace-Beltrami operator for the orbit space of Hamiltonian SU(2) gauge theory on a finite, rectangular lattice. This is done using a complete axial gauge fixing. The Gribov problem can be completely solved, with no remaining gauge ambiguities.Comment: Title is changed in journal. Now 19 pages, still one figure, AMSTe

    Consciousness as a necessary element of evolution of the cosmos

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    The article considers the ideas of the early work of E.V. Ilyenkov "Cosmology of the Spirit" of necessity and inevitability of matter to create consciousness. Dialectics of subject responses to impacts of the outside world is represented from the materialist point of view: from mechanical response in inanimate nature to subject and activity-oriented nature of human consciousnes

    Ἀντιάνειραι: Applying a Model of Homeric Warriorship to Female Warriors in Ancient Greek Literature

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    In this thesis, I attempt to address the erasure of female warriors from the discussion of Homeric warriorship. I first create a model of the attributes and values of the Homeric warrior, based on the men of the Iliad. I then apply that model to four women: three Amazons—Penthesileia, Antiope, and Hippolyta—and one Greek—Atalanta—to show the ways in which they fit into the model. I conclude by examining the erasure of these women in other Homeric warrior models, and ultimately argue that these women are crucial to the study of warriorship, and should be considered as such in scholarship going forward

    A laser spectrometer and wavemeter for pulsed lasers

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    The design, construction, calibration, and evaluation of a pulsed laser wavemeter and spectral analyzer are described. This instrument, called the Laserscope for its oscilloscope-like display of laser spectral structure, was delivered to NASA Langley Research Center as a prototype of a laboratory instrument. The key component is a multibeam Fizeau wedge interferometer, providing high (0.2 pm) spectral resolution and a linear dispersion of spectral information, ideally suited to linear array photodiode detectors. Even operating alone, with the classic order-number ambiguity of interferometers unresolved, this optical element will provide a fast, real-time display of the spectral structure of a laser output. If precise wavelength information is also desired then additional stages must be provided to obtain a wavelength measurement within the order-number uncertainty, i.e., within the free spectral range of the Fizeau wedge interferometer. A Snyder (single-beam Fizeau) wedge is included to provide this initial wavelength measurement. Difficulties in achieving the required wide-spectrum calibration limit the usefulness of this function

    Strategies for Precision Modulation of Gene Expression by Epigenome Editing: An Overview

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    Genome editing technology has evolved rather quickly and become accessible to most researchers. It has resulted in far reaching implications and a number of novel designer systems including epigenome editing. Epigenome editing utilizes a combination of nuclease-null genome editing systems and effector domains to modulate gene expression. In particular, Zinc Finger, Transcription-Activator-Like Effector, and CRISPR/Cas9 have emerged as modular systems that can be modified to allow for precision manipulation of epigenetic marks without altering underlying DNA sequence. This review contains a comprehensive catalog of effector domains that can be used with components of genome editing systems to achieve epigenome editing. Ultimately, the evidence-based design of epigenome editing offers a novel improvement to the limited attenuation strategies. There is much potential for editing and/or correcting gene expression in somatic cells toward a new era of functional genomics and personalized medicine

    Tolerance to Self: Which Cells Kill

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    Immune self tolerance involves the deletion in the thymus of developing T cells that have the ability to recognize self-antigens, but by which cells? New evidence argues that cortical epithelial cells can induce deletion of self-reactive T cells

    Endocrine-disrupting alkylphenols are widespread in the blood of lobsters from southern New England and adjacent offshore areas

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    Author Posting. © National Shellfisheries Association , 2012. This article is posted here by permission of National Shellfisheries Association for personal use, not for redistribution. The definitive version was published in Journal of Shellfish Research 31 (2012): 563-571, doi:10.2983/035.031.0216.Endocrine-disrupting pollutants in rivers and oceans represent a poorly understood but potentially serious threat to the integrity of aquatic and coastal ecosystems. We surveyed the hemolymph of lobsters from across southern New England and adjacent offshore areas for 3 endocrine-disrupting alkylphenols. We found all 3 compounds in hemolymph from every year and almost every region sampled. Prevalence of contamination varied significantly between regions, ranging from 45% of lobsters from southern Massachusetts to 17% of lobsters from central Long Island Sound. Mean contamination levels varied significantly as a function of region, year sampled, and collection trip, and were highest overall in lobsters from western Long Island Sound and lowest in lobsters from central Long Island Sound. Surprisingly, lobsters from offshore areas were not less contaminated than lobsters from inshore areas. Contamination levels also did not vary as a function of lobster size or shell disease signs. Contaminated lobsters held in the laboratory did not retain alkylphenols, suggesting that hemolymph contamination levels represent recent, rather than long-term, exposure. Our data set is the first, to our knowledge, to survey endocrine-disrupting contaminants in a population across such a broad temporal and spatial scale. We show that alkylphenol contamination is a persistent, widespread, but environmentally heterogeneous problem in lobster populations in southern New England and adjacent offshore areas. Our work raises serious questions about the prevalence and accumulation of these endocrine-disrupting pollutants in an important fishery species.This work was supported by the National Marine Fisheries Service as the New England Lobster Research Initiative: Lobster Shell Disease under NOAA grant NA06NMF4720100 to the University of Rhode Island Fisheries Center
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