PulsarSpectrum: simulating gamma-ray pulsars for the GLAST mission

We present here an overview of PulsarSpectrum, a program that simulates the gamma ray emission from pulsars. This simulator reproduces not only the basic features of the observed gamma ray pulsars, but it can also simulate more detailed effects related to pulsar timing. It is a very useful tool to understand the GLAST capabilities in the pulsar science.Comment: 6 pages, 3 figures, contribution for "Third Workshop on Science with the New Generation of High Energy Gamma-ray Experiments", May 2005, Cividale del Friuli (UD), Ital

A gain-scheduled PID controller for propofol dosing in anesthesia

6siA gain-scheduled proportional-integral-derivative controller is proposed for the closed-loop dosing of propofol in anesthesia (with the bispectral index as a controlled variable). In particular, it is shown that a different tuning of the parameters should be used during the infusion and maintenance phases. Further, the role of the noise filter is investigated.nonenonePadula, F.; Ionescu, C.; Latronico, N.; Paltenghi, M.; Visioli, A.; Vivacqua, G.Padula, Fabrizio; Ionescu, C.; Latronico, Nicola; Paltenghi, M.; Visioli, Antonio; Vivacqua, Giuli

Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation

Isothiocyanates (ITCs), present as glucosinolate precursors in cruciferous vegetables, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of three different ITCs on ROS production and on the expression of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of various neurological diseases. Primary cultures of rat astrocytes were activated by LPS and simultaneously treated with different doses of Allyl isothiocyanate (AITC), 2-Phenethyl isothiocyanate (PEITC) and 2-Sulforaphane (SFN). Results showed that SFN and PEITC were able to counteract ROS production induced by H2O2. The zymographic analysis of cell culture supernatants evidenced that PEITC and SFN were the most effective inhibitors of MMP-9, whereas, only SFN significantly inhibited MMP-2 activity. PCR analysis showed that all the ITCs used significantly inhibited both MMP-2 and MMP-9 expression. The investigation on the mitogen-activated protein kinase (MAPK) signaling pathway demonstrated that ITCs modulate MMP transcription by inhibition of extracellular-regulated protein kinase (ERK) activity. Results of this study suggest that ITCs could be promising nutraceutical agents for the prevention and complementary treatment of neurological diseases associated with MMP involvement

Reading a GEM with a VLSI pixel ASIC used as a direct charge collecting anode

In MicroPattern Gas Detectors (MPGD) when the pixel size is below 100 micron and the number of pixels is large (above 1000) it is virtually impossible to use the conventional PCB read-out approach to bring the signal charge from the individual pixel to the external electronics chain. For this reason a custom CMOS array of 2101 active pixels with 80 micron pitch, directly used as the charge collecting anode of a GEM amplifying structure, has been developed and built. Each charge collecting pad, hexagonally shaped, realized using the top metal layer of a deep submicron VLSI technology is individually connected to a full electronics chain (pre-amplifier, shaping-amplifier, sample and hold, multiplexer) which is built immediately below it by using the remaining five active layers. The GEM and the drift electrode window are assembled directly over the chip so the ASIC itself becomes the pixelized anode of a MicroPattern Gas Detector. With this approach, for the first time, gas detectors have reached the level of integration and resolution typical of solid state pixel detectors. Results from the first tests of this new read-out concept are presented. An Astronomical X-Ray Polarimetry application is also discussed.Comment: 11 pages, 14 figures, presented at the Xth Vienna Conference on Instrumentation (Vienna, February 16-21 2004). For a higher resolution paper contact [email protected]

A lentiviral vector with a short troponin-I promoter for tracking cardiomyocyte differentiation of human embryonic stem cells

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Substrate-less, spark-free micro-strip gas counters

Abstract We review recent work involving micro-strip gas counters with "advanced passivated" cathode strips. We present results from tests of a new variation of the MSGC, the planar micro-gap counter (PMGC), with very small ( ∼10 μ m) anode–cathode gap. Gains of up to 3×10 4 were achieved and gain variations due to charging effects were less than 10% using an ordinary (uncoated) boro-silicate glass substrate. The PMGC showed no reduction in gain when subjected to an X-ray flux of 4×10 5 Hz/mm 2 and survived exposure to alpha particles equivalent to 75 days' running at LHC with no signs of strip damage

ADJUSTABLE SUTURE STRABISMUS SURGERY: A REVIEW OF 850 CASES

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CHILDHOOD BLEPHAROPTOSIS: A REVIEW OF 113 CASES

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